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PubMed code 3127587

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Renin


(Homo sapiens (Human))		BDBM50022531
PNG
((+)2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholi...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)C(=O)OC(C)C
Show InChI InChI=1S/C35H47N5O7/c1-22(2)16-29(32(42)35(45)47-23(3)4)38-34(44)30(19-27-20-36-21-37-27)39-33(43)26(18-31(41)40-12-14-46-15-13-40)17-25-10-7-9-24-8-5-6-11-28(24)25/h5-11,20-23,26,29-30,32,42H,12-19H2,1-4H3,(H,36,37)(H,38,44)(H,39,43)
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n/an/a 7.80n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from human

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022525
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12
Show InChI InChI=1S/C33H43N5O7/c1-21(2)15-27(30(40)33(43)44-3)36-32(42)28(18-25-19-34-20-35-25)37-31(41)24(17-29(39)38-11-13-45-14-12-38)16-23-9-6-8-22-7-4-5-10-26(22)23/h4-10,19-21,24,27-28,30,40H,11-18H2,1-3H3,(H,34,35)(H,36,42)(H,37,41)
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n/an/a 11n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against human renin

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022526
PNG
((-)2-Hydroxy-3-{3-(1H-imidazol-4-yl)-2-[3-naphthal...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)NCCc1ccccc1)Cc1cccc2ccccc12
Show InChI InChI=1S/C37H45N5O6/c1-24(2)18-31(34(44)37(47)48-3)41-36(46)32(21-29-22-38-23-40-29)42-35(45)28(19-27-14-9-13-26-12-7-8-15-30(26)27)20-33(43)39-17-16-25-10-5-4-6-11-25/h4-15,22-24,28,31-32,34,44H,16-21H2,1-3H3,(H,38,40)(H,39,43)(H,41,46)(H,42,45)
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n/an/a 21n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from dog

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022529
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(2-naphthalen-...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCCCC1)Cc1cccc2ccccc12
Show InChI InChI=1S/C34H45N5O6/c1-22(2)16-28(31(41)34(44)45-3)37-33(43)29(19-26-20-35-21-36-26)38-32(42)25(18-30(40)39-14-7-4-8-15-39)17-24-12-9-11-23-10-5-6-13-27(23)24/h5-6,9-13,20-22,25,28-29,31,41H,4,7-8,14-19H2,1-3H3,(H,35,36)(H,37,43)(H,38,42)
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n/an/a 24n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from dog

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022530
PNG
(3-[2-(3-Dimethylcarbamoyl-2-naphthalen-1-ylmethyl-...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N(C)C)Cc1cccc2ccccc12
Show InChI InChI=1S/C31H41N5O6/c1-19(2)13-25(28(38)31(41)42-5)34-30(40)26(16-23-17-32-18-33-23)35-29(39)22(15-27(37)36(3)4)14-21-11-8-10-20-9-6-7-12-24(20)21/h6-12,17-19,22,25-26,28,38H,13-16H2,1-5H3,(H,32,33)(H,34,40)(H,35,39)
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n/an/a 25n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from human

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022530
PNG
(3-[2-(3-Dimethylcarbamoyl-2-naphthalen-1-ylmethyl-...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N(C)C)Cc1cccc2ccccc12
Show InChI InChI=1S/C31H41N5O6/c1-19(2)13-25(28(38)31(41)42-5)34-30(40)26(16-23-17-32-18-33-23)35-29(39)22(15-27(37)36(3)4)14-21-11-8-10-20-9-6-7-12-24(20)21/h6-12,17-19,22,25-26,28,38H,13-16H2,1-5H3,(H,32,33)(H,34,40)(H,35,39)
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n/an/a 25n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from dog

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022531
PNG
((+)2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholi...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)C(=O)OC(C)C
Show InChI InChI=1S/C35H47N5O7/c1-22(2)16-29(32(42)35(45)47-23(3)4)38-34(44)30(19-27-20-36-21-37-27)39-33(43)26(18-31(41)40-12-14-46-15-13-40)17-25-10-7-9-24-8-5-6-11-28(24)25/h5-11,20-23,26,29-30,32,42H,12-19H2,1-4H3,(H,36,37)(H,38,44)(H,39,43)
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n/an/a 25n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from dog

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022529
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(2-naphthalen-...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCCCC1)Cc1cccc2ccccc12
Show InChI InChI=1S/C34H45N5O6/c1-22(2)16-28(31(41)34(44)45-3)37-33(43)29(19-26-20-35-21-36-26)38-32(42)25(18-30(40)39-14-7-4-8-15-39)17-24-12-9-11-23-10-5-6-13-27(23)24/h5-6,9-13,20-22,25,28-29,31,41H,4,7-8,14-19H2,1-3H3,(H,35,36)(H,37,43)(H,38,42)
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n/an/a 41n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from human

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022525
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12
Show InChI InChI=1S/C33H43N5O7/c1-21(2)15-27(30(40)33(43)44-3)36-32(42)28(18-25-19-34-20-35-25)37-31(41)24(17-29(39)38-11-13-45-14-12-38)16-23-9-6-8-22-7-4-5-10-26(22)23/h4-10,19-21,24,27-28,30,40H,11-18H2,1-3H3,(H,34,35)(H,36,42)(H,37,41)
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n/an/a 52n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against human renin

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022530
PNG
(3-[2-(3-Dimethylcarbamoyl-2-naphthalen-1-ylmethyl-...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N(C)C)Cc1cccc2ccccc12
Show InChI InChI=1S/C31H41N5O6/c1-19(2)13-25(28(38)31(41)42-5)34-30(40)26(16-23-17-32-18-33-23)35-29(39)22(15-27(37)36(3)4)14-21-11-8-10-20-9-6-7-12-24(20)21/h6-12,17-19,22,25-26,28,38H,13-16H2,1-5H3,(H,32,33)(H,34,40)(H,35,39)
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n/an/a 64n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from human

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022527
PNG
(3-Hydroxy-4-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)CC(=O)OC(C)C
Show InChI InChI=1S/C36H49N5O7/c1-23(2)16-30(32(42)20-34(44)48-24(3)4)39-36(46)31(19-28-21-37-22-38-28)40-35(45)27(18-33(43)41-12-14-47-15-13-41)17-26-10-7-9-25-8-5-6-11-29(25)26/h5-11,21-24,27,30-32,42H,12-20H2,1-4H3,(H,37,38)(H,39,46)(H,40,45)
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n/an/a 66n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from human

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022527
PNG
(3-Hydroxy-4-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)CC(=O)OC(C)C
Show InChI InChI=1S/C36H49N5O7/c1-23(2)16-30(32(42)20-34(44)48-24(3)4)39-36(46)31(19-28-21-37-22-38-28)40-35(45)27(18-33(43)41-12-14-47-15-13-41)17-26-10-7-9-25-8-5-6-11-29(25)26/h5-11,21-24,27,30-32,42H,12-20H2,1-4H3,(H,37,38)(H,39,46)(H,40,45)
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n/an/a 66n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from dog

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022526
PNG
((-)2-Hydroxy-3-{3-(1H-imidazol-4-yl)-2-[3-naphthal...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)NCCc1ccccc1)Cc1cccc2ccccc12
Show InChI InChI=1S/C37H45N5O6/c1-24(2)18-31(34(44)37(47)48-3)41-36(46)32(21-29-22-38-23-40-29)42-35(45)28(19-27-14-9-13-26-12-7-8-15-30(26)27)20-33(43)39-17-16-25-10-5-4-6-11-25/h4-15,22-24,28,31-32,34,44H,16-21H2,1-3H3,(H,38,40)(H,39,43)(H,41,46)(H,42,45)
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n/an/a 78n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against human renin

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022526
PNG
((-)2-Hydroxy-3-{3-(1H-imidazol-4-yl)-2-[3-naphthal...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)NCCc1ccccc1)Cc1cccc2ccccc12
Show InChI InChI=1S/C37H45N5O6/c1-24(2)18-31(34(44)37(47)48-3)41-36(46)32(21-29-22-38-23-40-29)42-35(45)28(19-27-14-9-13-26-12-7-8-15-30(26)27)20-33(43)39-17-16-25-10-5-4-6-11-25/h4-15,22-24,28,31-32,34,44H,16-21H2,1-3H3,(H,38,40)(H,39,43)(H,41,46)(H,42,45)
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n/an/a 90n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from human

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022524
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)C(=O)NC(C)C
Show InChI InChI=1S/C35H48N6O6/c1-22(2)16-29(32(43)35(46)38-23(3)4)39-34(45)30(19-27-20-36-21-37-27)40-33(44)26(18-31(42)41-12-14-47-15-13-41)17-25-10-7-9-24-8-5-6-11-28(24)25/h5-11,20-23,26,29-30,32,43H,12-19H2,1-4H3,(H,36,37)(H,38,46)(H,39,45)(H,40,44)
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n/an/a 130n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against human renin

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022524
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)C(=O)NC(C)C
Show InChI InChI=1S/C35H48N6O6/c1-22(2)16-29(32(43)35(46)38-23(3)4)39-34(45)30(19-27-20-36-21-37-27)40-33(44)26(18-31(42)41-12-14-47-15-13-41)17-25-10-7-9-24-8-5-6-11-28(24)25/h5-11,20-23,26,29-30,32,43H,12-19H2,1-4H3,(H,36,37)(H,38,46)(H,39,45)(H,40,44)
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n/an/a 130n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against human renin

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022531
PNG
((+)2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholi...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)C(=O)OC(C)C
Show InChI InChI=1S/C35H47N5O7/c1-22(2)16-29(32(42)35(45)47-23(3)4)38-34(44)30(19-27-20-36-21-37-27)39-33(43)26(18-31(41)40-12-14-46-15-13-40)17-25-10-7-9-24-8-5-6-11-28(24)25/h5-11,20-23,26,29-30,32,42H,12-19H2,1-4H3,(H,36,37)(H,38,44)(H,39,43)
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n/an/a 150n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against human renin

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022527
PNG
(3-Hydroxy-4-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)CC(=O)OC(C)C
Show InChI InChI=1S/C36H49N5O7/c1-23(2)16-30(32(42)20-34(44)48-24(3)4)39-36(46)31(19-28-21-37-22-38-28)40-35(45)27(18-33(43)41-12-14-47-15-13-41)17-26-10-7-9-25-8-5-6-11-29(25)26/h5-11,21-24,27,30-32,42H,12-20H2,1-4H3,(H,37,38)(H,39,46)(H,40,45)
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n/an/a 350n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from human

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022529
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(2-naphthalen-...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCCCC1)Cc1cccc2ccccc12
Show InChI InChI=1S/C34H45N5O6/c1-22(2)16-28(31(41)34(44)45-3)37-33(43)29(19-26-20-35-21-36-26)38-32(42)25(18-30(40)39-14-7-4-8-15-39)17-24-12-9-11-23-10-5-6-13-27(23)24/h5-6,9-13,20-22,25,28-29,31,41H,4,7-8,14-19H2,1-3H3,(H,35,36)(H,37,43)(H,38,42)
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n/an/a 420n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from dog

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022528
PNG
((+)2-Hydroxy-3-{3-(1H-imidazol-4-yl)-2-[3-naphthal...)
Show SMILES COC(=O)[C@H](O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)NCCc1ccccc1)Cc1cccc2ccccc12
Show InChI InChI=1S/C37H45N5O6/c1-24(2)18-31(34(44)37(47)48-3)41-36(46)32(21-29-22-38-23-40-29)42-35(45)28(19-27-14-9-13-26-12-7-8-15-30(26)27)20-33(43)39-17-16-25-10-5-4-6-11-25/h4-15,22-24,28,31-32,34,44H,16-21H2,1-3H3,(H,38,40)(H,39,43)(H,41,46)(H,42,45)/t28?,31?,32?,34-/m1/s1
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n/an/a 770n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from human

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022525
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12
Show InChI InChI=1S/C33H43N5O7/c1-21(2)15-27(30(40)33(43)44-3)36-32(42)28(18-25-19-34-20-35-25)37-31(41)24(17-29(39)38-11-13-45-14-12-38)16-23-9-6-8-22-7-4-5-10-26(22)23/h4-10,19-21,24,27-28,30,40H,11-18H2,1-3H3,(H,34,35)(H,36,42)(H,37,41)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from dog

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022524
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)C(=O)NC(C)C
Show InChI InChI=1S/C35H48N6O6/c1-22(2)16-29(32(43)35(46)38-23(3)4)39-34(45)30(19-27-20-36-21-37-27)40-33(44)26(18-31(42)41-12-14-47-15-13-41)17-25-10-7-9-24-8-5-6-11-28(24)25/h5-11,20-23,26,29-30,32,43H,12-19H2,1-4H3,(H,36,37)(H,38,46)(H,39,45)(H,40,44)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from dog

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022532
PNG
((+)(2)Hydroxy-3-{3-(1H-imidazol-4-yl)-2-[3-naphtha...)
Show SMILES COC(=O)[C@@H](O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)NCCc1ccccc1)Cc1cccc2ccccc12
Show InChI InChI=1S/C37H45N5O6/c1-24(2)18-31(34(44)37(47)48-3)41-36(46)32(21-29-22-38-23-40-29)42-35(45)28(19-27-14-9-13-26-12-7-8-15-30(26)27)20-33(43)39-17-16-25-10-5-4-6-11-25/h4-15,22-24,28,31-32,34,44H,16-21H2,1-3H3,(H,38,40)(H,39,43)(H,41,46)(H,42,45)/t28?,31?,32?,34-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against human renin

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022528
PNG
((+)2-Hydroxy-3-{3-(1H-imidazol-4-yl)-2-[3-naphthal...)
Show SMILES COC(=O)[C@H](O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)NCCc1ccccc1)Cc1cccc2ccccc12
Show InChI InChI=1S/C37H45N5O6/c1-24(2)18-31(34(44)37(47)48-3)41-36(46)32(21-29-22-38-23-40-29)42-35(45)28(19-27-14-9-13-26-12-7-8-15-30(26)27)20-33(43)39-17-16-25-10-5-4-6-11-25/h4-15,22-24,28,31-32,34,44H,16-21H2,1-3H3,(H,38,40)(H,39,43)(H,41,46)(H,42,45)/t28?,31?,32?,34-/m1/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against human renin

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Rattus norvegicus)		BDBM50022524
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)C(=O)NC(C)C
Show InChI InChI=1S/C35H48N6O6/c1-22(2)16-29(32(43)35(46)38-23(3)4)39-34(45)30(19-27-20-36-21-37-27)40-33(44)26(18-31(42)41-12-14-47-15-13-41)17-25-10-7-9-24-8-5-6-11-28(24)25/h5-11,20-23,26,29-30,32,43H,12-19H2,1-4H3,(H,36,37)(H,38,46)(H,39,45)(H,40,44)
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n/an/a 4.40E+3n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from rat

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Rattus norvegicus)		BDBM50022531
PNG
((+)2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholi...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)C(=O)OC(C)C
Show InChI InChI=1S/C35H47N5O7/c1-22(2)16-29(32(42)35(45)47-23(3)4)38-34(44)30(19-27-20-36-21-37-27)39-33(43)26(18-31(41)40-12-14-46-15-13-40)17-25-10-7-9-24-8-5-6-11-28(24)25/h5-11,20-23,26,29-30,32,42H,12-19H2,1-4H3,(H,36,37)(H,38,44)(H,39,43)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from rat

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022526
PNG
((-)2-Hydroxy-3-{3-(1H-imidazol-4-yl)-2-[3-naphthal...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)NCCc1ccccc1)Cc1cccc2ccccc12
Show InChI InChI=1S/C37H45N5O6/c1-24(2)18-31(34(44)37(47)48-3)41-36(46)32(21-29-22-38-23-40-29)42-35(45)28(19-27-14-9-13-26-12-7-8-15-30(26)27)20-33(43)39-17-16-25-10-5-4-6-11-25/h4-15,22-24,28,31-32,34,44H,16-21H2,1-3H3,(H,38,40)(H,39,43)(H,41,46)(H,42,45)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against human renin

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Rattus norvegicus)		BDBM50022526
PNG
((-)2-Hydroxy-3-{3-(1H-imidazol-4-yl)-2-[3-naphthal...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)NCCc1ccccc1)Cc1cccc2ccccc12
Show InChI InChI=1S/C37H45N5O6/c1-24(2)18-31(34(44)37(47)48-3)41-36(46)32(21-29-22-38-23-40-29)42-35(45)28(19-27-14-9-13-26-12-7-8-15-30(26)27)20-33(43)39-17-16-25-10-5-4-6-11-25/h4-15,22-24,28,31-32,34,44H,16-21H2,1-3H3,(H,38,40)(H,39,43)(H,41,46)(H,42,45)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from rat

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Rattus norvegicus)		BDBM50022527
PNG
(3-Hydroxy-4-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)CC(=O)OC(C)C
Show InChI InChI=1S/C36H49N5O7/c1-23(2)16-30(32(42)20-34(44)48-24(3)4)39-36(46)31(19-28-21-37-22-38-28)40-35(45)27(18-33(43)41-12-14-47-15-13-41)17-26-10-7-9-25-8-5-6-11-29(25)26/h5-11,21-24,27,30-32,42H,12-20H2,1-4H3,(H,37,38)(H,39,46)(H,40,45)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from rat

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Rattus norvegicus)		BDBM50022525
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholin-4...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12
Show InChI InChI=1S/C33H43N5O7/c1-21(2)15-27(30(40)33(43)44-3)36-32(42)28(18-25-19-34-20-35-25)37-31(41)24(17-29(39)38-11-13-45-14-12-38)16-23-9-6-8-22-7-4-5-10-26(22)23/h4-10,19-21,24,27-28,30,40H,11-18H2,1-3H3,(H,34,35)(H,36,42)(H,37,41)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from rat

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Rattus norvegicus)		BDBM50022529
PNG
(2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(2-naphthalen-...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCCCC1)Cc1cccc2ccccc12
Show InChI InChI=1S/C34H45N5O6/c1-22(2)16-28(31(41)34(44)45-3)37-33(43)29(19-26-20-35-21-36-26)38-32(42)25(18-30(40)39-14-7-4-8-15-39)17-24-12-9-11-23-10-5-6-13-27(23)24/h5-6,9-13,20-22,25,28-29,31,41H,4,7-8,14-19H2,1-3H3,(H,35,36)(H,37,43)(H,38,42)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from rat

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM50022531
PNG
((+)2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(4-morpholi...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCOCC1)Cc1cccc2ccccc12)C(O)C(=O)OC(C)C
Show InChI InChI=1S/C35H47N5O7/c1-22(2)16-29(32(42)35(45)47-23(3)4)38-34(44)30(19-27-20-36-21-37-27)39-33(43)26(18-31(41)40-12-14-46-15-13-40)17-25-10-7-9-24-8-5-6-11-28(24)25/h5-11,20-23,26,29-30,32,42H,12-19H2,1-4H3,(H,36,37)(H,38,44)(H,39,43)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against human renin

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
Renin


(Rattus norvegicus)		BDBM50022530
PNG
(3-[2-(3-Dimethylcarbamoyl-2-naphthalen-1-ylmethyl-...)
Show SMILES COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N(C)C)Cc1cccc2ccccc12
Show InChI InChI=1S/C31H41N5O6/c1-19(2)13-25(28(38)31(41)42-5)34-30(40)26(16-23-17-32-18-33-23)35-29(39)22(15-27(37)36(3)4)14-21-11-8-10-20-9-6-7-12-24(20)21/h6-12,17-19,22,25-26,28,38H,13-16H2,1-5H3,(H,32,33)(H,34,40)(H,35,39)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kissei Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration was measured against plasma renin from rat

J Med Chem 31: 701-4 (1988)


BindingDB Entry DOI: 10.7270/Q26H4GDB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%