The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27517811 |
12 |
Synthesis and T-type calcium channel-blocking effects of aryl(1,5-disubstituted-pyrazol-3-yl)methyl sulfonamides for neuropathic pain treatment. |
Korea Institute of Science & Technology (Kist) |
| 27933950 |
304 |
Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers. |
Actelion Pharmaceuticals |
| 27579577 |
91 |
Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers. |
Actelion Pharmaceuticals |
| 26296911 |
11 |
3-Benzamides and 3,4,5-trimethoxyphenyl amines as calcium channel blockers. |
Ewha Womans University |
| 24529871 |
7 |
Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist. |
Kyung Hee University |
| 23395659 |
27 |
Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers. |
Korea Institute of Science and Technology |
| 19951839 |
42 |
3D QSAR studies on 3,4-dihydroquinazolines as T-type calcium channel blocker by comparative molecular similarity indices analysis (CoMSIA). |
Kyung Hee University |
| 20621730 |
30 |
Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers. |
Institute of Science and Technology |
| 19447040 |
31 |
Quinazolindione derivatives as potent 5-HT3A receptor antagonists. |
Konkuk University |
| 17092715 |
21 |
Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers. |
Institute of Science and Technology |
| 15603940 |
12 |
Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers. |
Korea Institute of Science & Technology |
| 22177784 |
2 |
In vivo evaluation of oral anti-tumoral effect of 3,4-dihydroquinazoline derivative on solid tumor. |
Kyung Hee University |
| 21843937 |
31 |
Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers. |
Korea Institute of Science and Technology |
| 21875808 |
31 |
Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents. |
Astellas Pharma |
| 21316226 |
12 |
Pyridyl amides as potent inhibitors of T-type calcium channels. |
Merck Research Laboratories |
| 21126876 |
16 |
Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers. |
Institute of Science and Technology |
| 20659804 |
19 |
Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity. |
Ewha Womans University |
| 20382529 |
13 |
Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers. |
Institute of Science and Technology |
| 18817368 |
57 |
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels. |
Merck Research Laboratories |
| 18625556 |
20 |
Synthesis and evaluation of alpha,alpha'-disubstituted phenylacetate derivatives for T-type calcium channel blockers. |
Institute of Science and Technology |
| 18585035 |
13 |
T-type Ca2+ channel blockers suppress the growth of human cancer cells. |
Kyung Hee University |
| 17869104 |
5 |
Discovery of potent T-type calcium channel blocker. |
Kyung Hee University |
| 17150365 |
29 |
Lead discovery and optimization of T-type calcium channel blockers. |
Institute of Science and Technology |
| 17074493 |
19 |
3D pharmacophore based virtual screening of T-type calcium channel blockers. |
Institute of Science and Technology |
| 17064894 |
7 |
Synthesis and biological evaluation of novel T-type calcium channel blockers. |
Kyung Hee University |
| 17035033 |
17 |
Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives. |
Institute of Science and Technology |
| 16876404 |
15 |
Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers. |
Institute of Science and Technology |
| 15177437 |
10 |
3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers. |
Institute of Science & Technology |
| 32327350 |
38 |
Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers. |
Kyung Hee University |
| 27591007 |
16 |
Synthesis and evaluation of 6-pyrazoylamido-3N-substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain. |
Korea Institute of Science & Technology (Kist) |
| 30928197 |
13 |
Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model. |
Korea Institute of Science and Technology |
| 31999455 |
5 |
Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca |
Chinese Academy of Sciences |
| 30538065 |
48 |
The discovery and optimization of benzimidazoles as selective Na |
Pfizer |
| 24412109 |
18 |
Successful reduction of off-target hERG toxicity by structural modification of a T-type calcium channel blocker. |
The Catholic University of Korea |
| 24220170 |
8 |
In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers. |
Kyung Hee University |
| 30031654 |
14 |
Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers. |
University of Toyama |
| 29116786 |
265 |
Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies. |
Idorsia Pharmaceuticals |
| 29074257 |
115 |
Discovery and evaluation of Ca |
Idorsia Pharmaceuticals |
| 29066309 |
87 |
Discovery and evaluation of Ca |
Idorsia Pharmaceuticals |
| 12534275 |
32 |
A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance. |
The Johns Hopkins University |
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