The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27865702 |
2 |
Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism. |
Riken Csrs |
| 27793568 |
2 |
Functional 1,3a,6a-triazapentalene scaffold: Design of fluorescent probes for kinesin spindle protein (KSP). |
University of Shizuoka |
| 26396688 |
26 |
Structure-Guided Design of Novel l-Cysteine Derivatives as Potent KSP Inhibitors. |
University of Shizuoka |
| 25868746 |
27 |
Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors. |
Merck Research Laboratories |
| 25001485 |
8 |
Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives. |
Kyowa Hakko Kirin |
| 25453799 |
1 |
Design, synthesis and anticancer evaluation of tetrahydro-ß-carboline-hydantoin hybrids. |
TBA |
| 24794744 |
54 |
Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors. |
Kyoto University |
| 24184776 |
19 |
Synthesis, biological evaluation and molecular docking studies of flavone and isoflavone derivatives as a novel class of KSP (kinesin spindle protein) inhibitors. |
Nanjing University |
| 23899248 |
1 |
Resistance by allostery: a novel perspective for eg5-targeted drug design. |
Korea Institute of Science and Technology |
| 23875972 |
3 |
Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism. |
The Beatson Institute For Cancer Research |
| 23434636 |
25 |
Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents. |
Cairo University |
| 23394180 |
68 |
Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. |
The Beatson Institute For Cancer Research |
| 23287057 |
1 |
Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent. |
Csir-Central Drug Research Institute |
| 22749640 |
36 |
Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine. |
University of Strathclyde |
| 22309208 |
8 |
Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors. |
Korea Institute of Science and Technology |
| 22248262 |
101 |
Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity. |
The Beatson Institute For Cancer Research |
| 20149654 |
66 |
The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. |
Merck Serono |
| 17095225 |
40 |
Pharmacophore identification of KSP inhibitors. |
China Pharmaceutical University |
| 16730979 |
16 |
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 21620536 |
1 |
Recent progress in biological activities of synthesized phenothiazines. |
The Medical University of Silesia |
| 21899292 |
76 |
Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. |
Astrazeneca |
| 21856161 |
34 |
De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. |
China Pharmaceutical University |
| 21855351 |
14 |
Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity. |
New Mexico State University |
| 21620531 |
1 |
Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones. |
Indian Institute of Chemical Technology |
| 21599002 |
19 |
Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors. |
Kyoto University |
| 21344920 |
36 |
Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5. |
Institute For Cancer Research |
| 20934346 |
46 |
Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. |
China Pharmaceutical University |
| 20597485 |
3 |
Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol. |
Institute For Cancer Research |
| 20521839 |
28 |
Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. |
Kyoto University |
| 20537544 |
30 |
Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. |
China Pharmaceutical University |
| 19945875 |
31 |
The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5. |
Novartis Institutes For Biomedical Research |
| 19481450 |
121 |
Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors. |
Schering-Plough Research Institute |
| 19167222 |
26 |
Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors. |
University of Shizuoka |
| 17251189 |
4 |
Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration. |
Cnrs-Commissariat à |
| 17804233 |
29 |
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP. |
Merck Research Laboratories |
| 17761419 |
16 |
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP. |
Merck Research Laboratories |
| 17725339 |
61 |
Novel ATP-competitive kinesin spindle protein inhibitors. |
Glaxosmithkline |
| 17587586 |
31 |
New chemical tools for investigating human mitotic kinesin Eg5. |
Cnrs-Université |
| 17524640 |
21 |
Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors. |
University of Shizuoka |
| 17395460 |
13 |
Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein. |
Merck Research Laboratories |
| 16884297 |
2 |
Inhibition of kinesin motor proteins by adociasulfate-2. |
University of Georgia |
| 16439122 |
16 |
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility. |
Merck Research Laboratories |
| 15808464 |
32 |
Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP. |
Merck Research Laboratories |
| 31648875 |
3 |
Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors. |
Tanta University |
| 31188592 |
39 |
Why Some Targets Benefit from beyond Rule of Five Drugs. |
Boston University |
| 28171832 |
1 |
Design and synthesis of novel phenyl -1, 4-beta-carboline-hybrid molecules as potential anticancer agents. |
Karnatak University |
| 30031975 |
26 |
Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors. |
University College London |
| 30015070 |
8 |
Synthesis and anticancer activity of new dihydropyrimidinone derivatives. |
Mansoura University |
| 30055887 |
28 |
Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5. |
University of Kwazulu-Natal (Ukzn) |
| 29454915 |
5 |
Synthesis of N-(1-(6-acetamido-5-phenylpyrimidin-4-yl) piperidin-3-yl) amide derivatives as potential inhibitors for mitotic kinesin spindle protein. |
Alagappa University |
| 28521172 |
11 |
Hetarylcoumarins: Synthesis and biological evaluation as potent a-glucosidase inhibitors. |
Kinnaird College For Women |
| 27434226 |
140 |
Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease. |
Wuhan University of Technology |
| 25144524 |
24 |
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein. |
Monash University |
| 12704225 |
26 |
Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram. |
University of Tennessee |
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