Found 76 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353767
(CHEMBL1829430)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H31N5O2S/c1-4-22(31(16-8-15-28)26(33)21-13-11-18(2)12-14-21)24-29-25-23(19(3)30-35-25)27(34)32(24)17-20-9-6-5-7-10-20/h5-7,9-14,22H,4,8,15-17,28H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353767
(CHEMBL1829430)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H31N5O2S/c1-4-22(31(16-8-15-28)26(33)21-13-11-18(2)12-14-21)24-29-25-23(19(3)30-35-25)27(34)32(24)17-20-9-6-5-7-10-20/h5-7,9-14,22H,4,8,15-17,28H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353788
(CHEMBL1829433)Show SMILES CC(C)C(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353788
(CHEMBL1829433)Show SMILES CC(C)C(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353799
(CHEMBL1829424)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2sccc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H30N4O2S/c1-3-23(30(16-7-15-28)26(32)21-12-10-19(2)11-13-21)24-29-25-22(14-17-34-25)27(33)31(24)18-20-8-5-4-6-9-20/h4-6,8-14,17,23H,3,7,15-16,18,28H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353767
(CHEMBL1829430)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H31N5O2S/c1-4-22(31(16-8-15-28)26(33)21-13-11-18(2)12-14-21)24-29-25-23(19(3)30-35-25)27(34)32(24)17-20-9-6-5-7-10-20/h5-7,9-14,22H,4,8,15-17,28H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353799
(CHEMBL1829424)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2sccc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H30N4O2S/c1-3-23(30(16-7-15-28)26(32)21-12-10-19(2)11-13-21)24-29-25-22(14-17-34-25)27(33)31(24)18-20-8-5-4-6-9-20/h4-6,8-14,17,23H,3,7,15-16,18,28H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353820
(CHEMBL1829432)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2c(C)nsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H31N5O2S/c1-4-22(31(16-8-15-28)26(33)21-13-11-18(2)12-14-21)25-29-23-19(3)30-35-24(23)27(34)32(25)17-20-9-6-5-7-10-20/h5-7,9-14,22H,4,8,15-17,28H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353799
(CHEMBL1829424)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2sccc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H30N4O2S/c1-3-23(30(16-7-15-28)26(32)21-12-10-19(2)11-13-21)24-29-25-22(14-17-34-25)27(33)31(24)18-20-8-5-4-6-9-20/h4-6,8-14,17,23H,3,7,15-16,18,28H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353821
(CHEMBL1829246)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H30N4O2S/c1-3-23(30(16-7-15-28)26(32)21-12-10-19(2)11-13-21)25-29-22-14-17-34-24(22)27(33)31(25)18-20-8-5-4-6-9-20/h4-6,8-14,17,23H,3,7,15-16,18,28H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353823
(CHEMBL1829422)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccoc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H30N4O3/c1-3-23(30(16-7-15-28)26(32)21-12-10-19(2)11-13-21)25-29-22-14-17-34-24(22)27(33)31(25)18-20-8-5-4-6-9-20/h4-6,8-14,17,23H,3,7,15-16,18,28H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353822
(CHEMBL1829431)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2onc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H31N5O3/c1-4-22(31(16-8-15-28)26(33)21-13-11-18(2)12-14-21)24-29-25-23(19(3)30-35-25)27(34)32(24)17-20-9-6-5-7-10-20/h5-7,9-14,22H,4,8,15-17,28H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353761
(CHEMBL1829406)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)c(F)c1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H29FN4O2S/c1-3-23(31(14-7-13-29)26(33)20-11-10-18(2)21(28)16-20)25-30-22-12-15-35-24(22)27(34)32(25)17-19-8-5-4-6-9-19/h4-6,8-12,15-16,23H,3,7,13-14,17,29H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353760
(CHEMBL1829248)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1cccc(F)c1 Show InChI InChI=1S/C27H29FN4O2S/c1-3-23(31(14-5-13-29)26(33)20-10-8-18(2)9-11-20)25-30-22-12-15-35-24(22)27(34)32(25)17-19-6-4-7-21(28)16-19/h4,6-12,15-16,23H,3,5,13-14,17,29H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353762
(CHEMBL1829423)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccn(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H33N5O2/c1-4-24(32(17-8-16-29)27(34)22-13-11-20(2)12-14-22)26-30-23-15-18-31(3)25(23)28(35)33(26)19-21-9-6-5-7-10-21/h5-7,9-15,18,24H,4,8,16-17,19,29H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353764
(CHEMBL1829420)Show SMILES CCC(N(CCCN)C(=O)c1ccc2ccccc2c1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C30H30N4O2S/c1-2-26(33(17-8-16-31)29(35)24-14-13-22-11-6-7-12-23(22)19-24)28-32-25-15-18-37-27(25)30(36)34(28)20-21-9-4-3-5-10-21/h3-7,9-15,18-19,26H,2,8,16-17,20,31H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353763
(CHEMBL1829401)Show SMILES CCC(N(CCCN)C(=O)c1ccc(Br)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C26H27BrN4O2S/c1-2-22(30(15-6-14-28)25(32)19-9-11-20(27)12-10-19)24-29-21-13-16-34-23(21)26(33)31(24)17-18-7-4-3-5-8-18/h3-5,7-13,16,22H,2,6,14-15,17,28H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353765
(CHEMBL1829418)Show SMILES CCC(N(CCCN)C(=O)c1cc2ccccc2s1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H28N4O2S2/c1-2-22(31(15-8-14-29)27(33)24-17-20-11-6-7-12-23(20)36-24)26-30-21-13-16-35-25(21)28(34)32(26)18-19-9-4-3-5-10-19/h3-7,9-13,16-17,22H,2,8,14-15,18,29H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353766
(CHEMBL1829399)Show SMILES CCC(N(CCCN)C(=O)c1ccc(Cl)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C26H27ClN4O2S/c1-2-22(30(15-6-14-28)25(32)19-9-11-20(27)12-10-19)24-29-21-13-16-34-23(21)26(33)31(24)17-18-7-4-3-5-8-18/h3-5,7-13,16,22H,2,6,14-15,17,28H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353768
(CHEMBL1829426)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2sc(Cl)cc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H29ClN4O2S/c1-3-22(31(15-7-14-29)26(33)20-12-10-18(2)11-13-20)24-30-25-21(16-23(28)35-25)27(34)32(24)17-19-8-5-4-6-9-19/h4-6,8-13,16,22H,3,7,14-15,17,29H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353769
(CHEMBL1828638)Show SMILES CCC(N(CCCN)C(=O)c1cccc(C)c1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H30N4O2S/c1-3-23(30(15-8-14-28)26(32)21-12-7-9-19(2)17-21)25-29-22-13-16-34-24(22)27(33)31(25)18-20-10-5-4-6-11-20/h4-7,9-13,16-17,23H,3,8,14-15,18,28H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353770
(CHEMBL1829407)Show SMILES CCC(N(CCCN)C(=O)c1ccc(CC)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H32N4O2S/c1-3-20-11-13-22(14-12-20)27(33)31(17-8-16-29)24(4-2)26-30-23-15-18-35-25(23)28(34)32(26)19-21-9-6-5-7-10-21/h5-7,9-15,18,24H,3-4,8,16-17,19,29H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353771
(CHEMBL1829250)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccc(C)cc1 Show InChI InChI=1S/C28H32N4O2S/c1-4-24(31(16-5-15-29)27(33)22-12-8-20(3)9-13-22)26-30-23-14-17-35-25(23)28(34)32(26)18-21-10-6-19(2)7-11-21/h6-14,17,24H,4-5,15-16,18,29H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353772
(CHEMBL1829247)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1F Show InChI InChI=1S/C27H29FN4O2S/c1-3-23(31(15-6-14-29)26(33)19-11-9-18(2)10-12-19)25-30-22-13-16-35-24(22)27(34)32(25)17-20-7-4-5-8-21(20)28/h4-5,7-13,16,23H,3,6,14-15,17,29H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353773
(CHEMBL1829410)Show SMILES CCC(N(CCCN)C(=O)c1ccc(F)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C26H27FN4O2S/c1-2-22(30(15-6-14-28)25(32)19-9-11-20(27)12-10-19)24-29-21-13-16-34-23(21)26(33)31(24)17-18-7-4-3-5-8-18/h3-5,7-13,16,22H,2,6,14-15,17,28H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353774
(CHEMBL1829425)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2sc(Br)cc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H29BrN4O2S/c1-3-22(31(15-7-14-29)26(33)20-12-10-18(2)11-13-20)24-30-25-21(16-23(28)35-25)27(34)32(24)17-19-8-5-4-6-9-19/h4-6,8-13,16,22H,3,7,14-15,17,29H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353776
(CHEMBL1829421)Show SMILES CCC(N(CCCN)C(=O)c1ccc2OCOc2c1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H28N4O4S/c1-2-21(30(13-6-12-28)26(32)19-9-10-22-23(15-19)35-17-34-22)25-29-20-11-14-36-24(20)27(33)31(25)16-18-7-4-3-5-8-18/h3-5,7-11,14-15,21H,2,6,12-13,16-17,28H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353775
(CHEMBL1829400)Show SMILES CCC(N(CCCN)C(=O)c1ccc(Cl)cc1Cl)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C26H26Cl2N4O2S/c1-2-22(31(13-6-12-29)25(33)19-10-9-18(27)15-20(19)28)24-30-21-11-14-35-23(21)26(34)32(24)16-17-7-4-3-5-8-17/h3-5,7-11,14-15,22H,2,6,12-13,16,29H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353777
(CHEMBL1829251)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccc(OC)cc1 Show InChI InChI=1S/C28H32N4O3S/c1-4-24(31(16-5-15-29)27(33)21-10-6-19(2)7-11-21)26-30-23-14-17-36-25(23)28(34)32(26)18-20-8-12-22(35-3)13-9-20/h6-14,17,24H,4-5,15-16,18,29H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353778
(CHEMBL1829427)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2sc(Cl)c(Br)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H28BrClN4O2S/c1-3-20(32(15-7-14-30)26(34)19-12-10-17(2)11-13-19)24-31-25-21(22(28)23(29)36-25)27(35)33(24)16-18-8-5-4-6-9-18/h4-6,8-13,20H,3,7,14-16,30H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 161 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353779
(CHEMBL1829270)Show SMILES CCC(N(CCCN)C(=O)c1ccccc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C26H28N4O2S/c1-2-22(29(16-9-15-27)25(31)20-12-7-4-8-13-20)24-28-21-14-17-33-23(21)26(32)30(24)18-19-10-5-3-6-11-19/h3-8,10-14,17,22H,2,9,15-16,18,27H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353780
(CHEMBL1829249)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccc(Cl)cc1 Show InChI InChI=1S/C27H29ClN4O2S/c1-3-23(31(15-4-14-29)26(33)20-9-5-18(2)6-10-20)25-30-22-13-16-35-24(22)27(34)32(25)17-19-7-11-21(28)12-8-19/h5-13,16,23H,3-4,14-15,17,29H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353782
(CHEMBL1829409)Show SMILES CCC(N(CCCN)C(=O)c1ccc(OC)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H30N4O3S/c1-3-23(30(16-7-15-28)26(32)20-10-12-21(34-2)13-11-20)25-29-22-14-17-35-24(22)27(33)31(25)18-19-8-5-4-6-9-19/h4-6,8-14,17,23H,3,7,15-16,18,28H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353781
(CHEMBL1829402)Show SMILES CCC(N(CCCN)C(=O)c1ccc(cc1)C(F)(F)F)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H27F3N4O2S/c1-2-22(33(15-6-14-31)25(35)19-9-11-20(12-10-19)27(28,29)30)24-32-21-13-16-37-23(21)26(36)34(24)17-18-7-4-3-5-8-18/h3-5,7-13,16,22H,2,6,14-15,17,31H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353784
(CHEMBL1829403)Show SMILES CCC(N(CCCN)C(=O)c1cccc(c1)C(F)(F)F)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H27F3N4O2S/c1-2-22(33(14-7-13-31)25(35)19-10-6-11-20(16-19)27(28,29)30)24-32-21-12-15-37-23(21)26(36)34(24)17-18-8-4-3-5-9-18/h3-6,8-12,15-16,22H,2,7,13-14,17,31H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353783
(CHEMBL1829259)Show SMILES CCC(N(CC1CNCCO1)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C29H32N4O3S/c1-3-25(32(19-23-17-30-14-15-36-23)28(34)22-11-9-20(2)10-12-22)27-31-24-13-16-37-26(24)29(35)33(27)18-21-7-5-4-6-8-21/h4-13,16,23,25,30H,3,14-15,17-19H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353785
(CHEMBL1829428)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ncccc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H31N5O2/c1-3-24(32(18-8-16-29)27(34)22-14-12-20(2)13-15-22)26-31-25-23(11-7-17-30-25)28(35)33(26)19-21-9-5-4-6-10-21/h4-7,9-15,17,24H,3,8,16,18-19,29H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 323 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353786
(CHEMBL1829258)Show SMILES CCC(N(CCCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H32N4O2S/c1-3-24(31(17-8-7-16-29)27(33)22-13-11-20(2)12-14-22)26-30-23-15-18-35-25(23)28(34)32(26)19-21-9-5-4-6-10-21/h4-6,9-15,18,24H,3,7-8,16-17,19,29H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353787
(CHEMBL1829415)Show SMILES CCC(N(CCCN)C(=O)c1sccc1C)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C25H28N4O2S2/c1-3-20(28(13-7-12-26)24(30)21-17(2)10-14-32-21)23-27-19-11-15-33-22(19)25(31)29(23)16-18-8-5-4-6-9-18/h4-6,8-11,14-15,20H,3,7,12-13,16,26H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353789
(CHEMBL1829413)Show SMILES CCC(N(CCCN)C(=O)c1ccco1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C24H26N4O3S/c1-2-19(27(13-7-12-25)23(29)20-10-6-14-31-20)22-26-18-11-15-32-21(18)24(30)28(22)16-17-8-4-3-5-9-17/h3-6,8-11,14-15,19H,2,7,12-13,16,25H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353790
(CHEMBL1829398)Show SMILES CCC(N(CCCN)C(=O)c1ccccc1Cl)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C26H27ClN4O2S/c1-2-22(30(15-8-14-28)25(32)19-11-6-7-12-20(19)27)24-29-21-13-16-34-23(21)26(33)31(24)17-18-9-4-3-5-10-18/h3-7,9-13,16,22H,2,8,14-15,17,28H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353791
(CHEMBL1829256)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1cc(C)on1 Show InChI InChI=1S/C25H29N5O3S/c1-4-21(29(12-5-11-26)24(31)18-8-6-16(2)7-9-18)23-27-20-10-13-34-22(20)25(32)30(23)15-19-14-17(3)33-28-19/h6-10,13-14,21H,4-5,11-12,15,26H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353792
(CHEMBL1829252)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1CC1CC1 Show InChI InChI=1S/C24H30N4O2S/c1-3-20(27(13-4-12-25)23(29)18-9-5-16(2)6-10-18)22-26-19-11-14-31-21(19)24(30)28(22)15-17-7-8-17/h5-6,9-11,14,17,20H,3-4,7-8,12-13,15,25H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 760 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353793
(CHEMBL1829408)Show SMILES CCC(N(CCCN)C(=O)c1ccc(cc1)C(C)C)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C29H34N4O2S/c1-4-25(32(17-8-16-30)28(34)23-13-11-22(12-14-23)20(2)3)27-31-24-15-18-36-26(24)29(35)33(27)19-21-9-6-5-7-10-21/h5-7,9-15,18,20,25H,4,8,16-17,19,30H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353794
(CHEMBL1829416)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)nc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C26H29N5O2S/c1-3-22(30(14-7-13-27)25(32)20-11-10-18(2)28-16-20)24-29-21-12-15-34-23(21)26(33)31(24)17-19-8-5-4-6-9-19/h4-6,8-12,15-16,22H,3,7,13-14,17,27H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353795
(CHEMBL1829405)Show SMILES CCC(N(CCCN)C(=O)c1ccccc1C)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H30N4O2S/c1-3-23(30(16-9-15-28)26(32)21-13-8-7-10-19(21)2)25-29-22-14-17-34-24(22)27(33)31(25)18-20-11-5-4-6-12-20/h4-8,10-14,17,23H,3,9,15-16,18,28H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353796
(CHEMBL1829260)Show SMILES CCC(N(C1CCNCC1)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C29H32N4O2S/c1-3-25(33(23-13-16-30-17-14-23)28(34)22-11-9-20(2)10-12-22)27-31-24-15-18-36-26(24)29(35)32(27)19-21-7-5-4-6-8-21/h4-12,15,18,23,25,30H,3,13-14,16-17,19H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353797
(CHEMBL1829414)Show SMILES CCC(N(CCCN)C(=O)c1ccno1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C23H25N5O3S/c1-2-18(27(13-6-11-24)22(29)19-9-12-25-31-19)21-26-17-10-14-32-20(17)23(30)28(21)15-16-7-4-3-5-8-16/h3-5,7-10,12,14,18H,2,6,11,13,15,24H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353798
(CHEMBL1829261)Show SMILES CCC(N(CC1CCNCC1)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C30H34N4O2S/c1-3-26(33(19-23-13-16-31-17-14-23)29(35)24-11-9-21(2)10-12-24)28-32-25-15-18-37-27(25)30(36)34(28)20-22-7-5-4-6-8-22/h4-12,15,18,23,26,31H,3,13-14,16-17,19-20H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353800
(CHEMBL1829417)Show SMILES CCC(N(CCCN)C(=O)C1COc2ccccc2O1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H30N4O4S/c1-2-21(31(15-8-14-29)27(33)24-18-35-22-11-6-7-12-23(22)36-24)26-30-20-13-16-37-25(20)28(34)32(26)17-19-9-4-3-5-10-19/h3-7,9-13,16,21,24H,2,8,14-15,17-18,29H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353801
(CHEMBL1829404)Show SMILES CCC(N(CCCN)C(=O)c1ccc(OC(F)(F)F)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H27F3N4O3S/c1-2-22(33(15-6-14-31)25(35)19-9-11-20(12-10-19)37-27(28,29)30)24-32-21-13-16-38-23(21)26(36)34(24)17-18-7-4-3-5-8-18/h3-5,7-13,16,22H,2,6,14-15,17,31H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353802
(CHEMBL1829411)Show SMILES CCC(N(CCCN)C(=O)c1ccc(cc1)C#N)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H27N5O2S/c1-2-23(31(15-6-14-28)26(33)21-11-9-19(17-29)10-12-21)25-30-22-13-16-35-24(22)27(34)32(25)18-20-7-4-3-5-8-20/h3-5,7-13,16,23H,2,6,14-15,18,28H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353803
(CHEMBL1829262)Show SMILES CCC(N(CCCNC(C)=O)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C29H32N4O3S/c1-4-25(32(17-8-16-30-21(3)34)28(35)23-13-11-20(2)12-14-23)27-31-24-15-18-37-26(24)29(36)33(27)19-22-9-6-5-7-10-22/h5-7,9-15,18,25H,4,8,16-17,19H2,1-3H3,(H,30,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353804
(CHEMBL1829419)Show SMILES CCC(N(CCCN)C(=O)c1ccc2nccnc2c1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H28N6O2S/c1-2-24(33(15-6-12-29)27(35)20-9-10-21-23(17-20)31-14-13-30-21)26-32-22-11-16-37-25(22)28(36)34(26)18-19-7-4-3-5-8-19/h3-5,7-11,13-14,16-17,24H,2,6,12,15,18,29H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353805
(CHEMBL1829253)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccccn1 Show InChI InChI=1S/C26H29N5O2S/c1-3-22(30(15-6-13-27)25(32)19-10-8-18(2)9-11-19)24-29-21-12-16-34-23(21)26(33)31(24)17-20-7-4-5-14-28-20/h4-5,7-12,14,16,22H,3,6,13,15,17,27H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353806
(CHEMBL1829254)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1cccnc1 Show InChI InChI=1S/C26H29N5O2S/c1-3-22(30(14-5-12-27)25(32)20-9-7-18(2)8-10-20)24-29-21-11-15-34-23(21)26(33)31(24)17-19-6-4-13-28-16-19/h4,6-11,13,15-16,22H,3,5,12,14,17,27H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353807
(CHEMBL1829268)Show SMILES CCC(N(CCCN)C(=O)C1CCCC1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C25H32N4O2S/c1-2-21(28(15-8-14-26)24(30)19-11-6-7-12-19)23-27-20-13-16-32-22(20)25(31)29(23)17-18-9-4-3-5-10-18/h3-5,9-10,13,16,19,21H,2,6-8,11-12,14-15,17,26H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353808
(CHEMBL1829266)Show SMILES CCC(N(CCCN)C(=O)CC(C)C)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C24H32N4O2S/c1-4-20(27(13-8-12-25)21(29)15-17(2)3)23-26-19-11-14-31-22(19)24(30)28(23)16-18-9-6-5-7-10-18/h5-7,9-11,14,17,20H,4,8,12-13,15-16,25H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353809
(CHEMBL1829255)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccncc1 Show InChI InChI=1S/C26H29N5O2S/c1-3-22(30(15-4-12-27)25(32)20-7-5-18(2)6-8-20)24-29-21-11-16-34-23(21)26(33)31(24)17-19-9-13-28-14-10-19/h5-11,13-14,16,22H,3-4,12,15,17,27H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353810
(CHEMBL1829429)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2nccnc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C27H30N6O2/c1-3-22(32(17-7-14-28)26(34)21-12-10-19(2)11-13-21)25-31-24-23(29-15-16-30-24)27(35)33(25)18-20-8-5-4-6-9-20/h4-6,8-13,15-16,22H,3,7,14,17-18,28H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353811
(CHEMBL1829265)Show SMILES CCCCC(=O)N(CCCN)C(CC)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C24H32N4O2S/c1-3-5-12-21(29)27(15-9-14-25)20(4-2)23-26-19-13-16-31-22(19)24(30)28(23)17-18-10-7-6-8-11-18/h6-8,10-11,13,16,20H,3-5,9,12,14-15,17,25H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353812
(CHEMBL1829412)Show SMILES CCC(N(CCCN)C(=O)c1ccc(cc1)C(=O)OC)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H30N4O4S/c1-3-23(31(16-7-15-29)26(33)20-10-12-21(13-11-20)28(35)36-2)25-30-22-14-17-37-24(22)27(34)32(25)18-19-8-5-4-6-9-19/h4-6,8-14,17,23H,3,7,15-16,18,29H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353813
(CHEMBL1829263)Show SMILES CCC(N(CCCNS(C)(=O)=O)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H32N4O4S2/c1-4-24(31(17-8-16-29-38(3,35)36)27(33)22-13-11-20(2)12-14-22)26-30-23-15-18-37-25(23)28(34)32(26)19-21-9-6-5-7-10-21/h5-7,9-15,18,24,29H,4,8,16-17,19H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353814
(CHEMBL1829267)Show SMILES CCC(N(CCCN)C(=O)C1CC1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C23H28N4O2S/c1-2-19(26(13-6-12-24)22(28)17-9-10-17)21-25-18-11-14-30-20(18)23(29)27(21)15-16-7-4-3-5-8-16/h3-5,7-8,11,14,17,19H,2,6,9-10,12-13,15,24H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353816
(CHEMBL1829269)Show SMILES CCC(N(CCCN)C(=O)C1CCC(CC1)OC)c1nc2ccsc2c(=O)n1Cc1ccccc1 |(38.06,-13.97,;38.06,-15.51,;36.73,-16.28,;36.73,-17.82,;38.06,-18.59,;39.39,-17.82,;40.72,-18.6,;42.05,-17.84,;35.39,-18.59,;34.06,-17.82,;35.39,-20.13,;34.05,-20.88,;34.05,-22.42,;35.38,-23.2,;36.71,-22.43,;36.72,-20.89,;35.37,-24.74,;34.03,-25.5,;35.39,-15.51,;34.07,-16.27,;32.74,-15.51,;31.26,-15.99,;30.35,-14.73,;31.26,-13.48,;32.74,-13.96,;34.07,-13.19,;34.07,-11.65,;35.39,-13.97,;36.73,-13.2,;36.74,-11.66,;38.07,-10.9,;38.08,-9.36,;36.75,-8.59,;35.4,-9.36,;35.41,-10.9,)| Show InChI InChI=1S/C27H36N4O3S/c1-3-23(30(16-7-15-28)26(32)20-10-12-21(34-2)13-11-20)25-29-22-14-17-35-24(22)27(33)31(25)18-19-8-5-4-6-9-19/h4-6,8-9,14,17,20-21,23H,3,7,10-13,15-16,18,28H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353817
(CHEMBL1829442)Show SMILES CCC(NC(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C24H23N3O2S/c1-3-19(26-23(28)18-11-9-16(2)10-12-18)22-25-20-13-14-30-21(20)24(29)27(22)15-17-7-5-4-6-8-17/h4-14,19H,3,15H2,1-2H3,(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353815
(CHEMBL1829245)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)[nH]1 Show InChI InChI=1S/C20H24N4O2S/c1-3-16(18-22-15-9-12-27-17(15)19(25)23-18)24(11-4-10-21)20(26)14-7-5-13(2)6-8-14/h5-9,12,16H,3-4,10-11,21H2,1-2H3,(H,22,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353818
(CHEMBL1829257)Show SMILES CCC(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1cscn1 Show InChI InChI=1S/C24H27N5O2S2/c1-3-20(28(11-4-10-25)23(30)17-7-5-16(2)6-8-17)22-27-19-9-12-33-21(19)24(31)29(22)13-18-14-32-15-26-18/h5-9,12,14-15,20H,3-4,10-11,13,25H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50353788
(CHEMBL1829433)Show SMILES CC(C)C(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CYP2C9 |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50353819
(CHEMBL1829264)Show SMILES CCC(N(CCCNC(=O)OC(C)(C)C)C(=O)c1ccc(C)cc1)c1nc2ccsc2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C32H38N4O4S/c1-6-26(28-34-25-17-20-41-27(25)30(38)36(28)21-23-11-8-7-9-12-23)35(29(37)24-15-13-22(2)14-16-24)19-10-18-33-31(39)40-32(3,4)5/h7-9,11-17,20,26H,6,10,18-19,21H2,1-5H3,(H,33,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C19
(Homo sapiens (Human)) | BDBM50353788
(CHEMBL1829433)Show SMILES CC(C)C(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CYP2C19 |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50353788
(CHEMBL1829433)Show SMILES CC(C)C(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CYP2D6 |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50353788
(CHEMBL1829433)Show SMILES CC(C)C(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CYP1A2 |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50353788
(CHEMBL1829433)Show SMILES CC(C)C(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CYP3A4 |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF23
(Homo sapiens (Human)) | BDBM50353788
(CHEMBL1829433)Show SMILES CC(C)C(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-MKLP1 after 20 mins by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
Kinesin-1 heavy chain
(Homo sapiens (Human)) | BDBM50353788
(CHEMBL1829433)Show SMILES CC(C)C(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C28H33N5O2S/c1-18(2)24(32(16-8-15-29)27(34)22-13-11-19(3)12-14-22)25-30-26-23(20(4)31-36-26)28(35)33(25)17-21-9-6-5-7-10-21/h5-7,9-14,18,24H,8,15-17,29H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human GST-conventional kinesin ATPase activity after 20 mins by malachite green assay |
J Med Chem 54: 6734-50 (2011)
Article DOI: 10.1021/jm200629m
BindingDB Entry DOI: 10.7270/Q2ZC838Z |
More data for this
Ligand-Target Pair | |
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