The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28324649 |
99 |
Sulfonamides as Selective Na |
Amgen |
28287723 |
73 |
Sulfonamides as Selective Na |
Amgen |
2579237 |
115 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. |
TBA |
27994738 |
50 |
Sulfonamides as Selective Na |
Amgen |
27038498 |
33 |
Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine. |
Gilead Sciences |
26985315 |
49 |
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models. |
Xenon Pharmaceuticals |
26358159 |
114 |
Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors. |
Daiichi Sankyo |
25927480 |
36 |
Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications. |
Merck Research Laboratories |
26101568 |
51 |
Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain. |
Pfizer |
21300721 |
90 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. |
University of Oxford |
24601592 |
48 |
Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis. |
University College London |
23121096 |
86 |
Ion channels as therapeutic targets: a drug discovery perspective. |
Pfizer |
16134928 |
34 |
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. |
The Scripps Research Institute |
11229757 |
5 |
Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788. |
Cambridge Neuroscience |
| 15 |
Batrachotoxin binding site antagonists |
TBA |
32392056 |
108 |
Discovery of DS-1971a, a Potent, Selective Na |
Daiichi Sankyo |
27441383 |
117 |
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors. |
Amgen |
31525968 |
170 |
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na |
Xenon Pharmaceuticals |
30943032 |
31 |
Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Na |
Genentech |
30538065 |
48 |
The discovery and optimization of benzimidazoles as selective Na |
Pfizer |
31012583 |
128 |
Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform Na |
Siteone Therapeutics |
29737846 |
70 |
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa |
Xenon Pharmaceuticals |
3016269 |
31 |
Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters. |
TBA |
29029933 |
45 |
Highly potent and selective Na |
Pfizer |
28682065 |
133 |
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na |
Icagen |
26833890 |
18 |
Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease. |
Yogi Vemana University |
26469307 |
7 |
Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b. |
University of Leipzig |
7932531 |
55 |
Inhibitors of HIV-1 proteinase containing 2-heterosubstituted 4-amino-3-hydroxy-5-phenylpentanoic acid: synthesis, enzyme inhibition, and antiviral activity. |
Sandoz Forschungsinstitut Ges.M.B.H. |