The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 15050627 |
49 |
Hydroxytriamides as potent gamma-secretase inhibitors. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 15177469 |
24 |
Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin. |
Tokyo University of Science |
| 27038496 |
2 |
Part 3: Notch-sparing¿-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones. |
Harvard Medical School |
| 27013392 |
10 |
Part 1: Notch-sparing¿-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs. |
Harvard Medical School |
| 26898338 |
4 |
Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based¿-secretase modulators. |
Bristol-Myers Squibb |
| 26848108 |
36 |
Design and optimization of tricyclic gamma-secretase modulators. |
Bristol-Myers Squibb Research and Development |
| 26496070 |
96 |
Discovery of a Novel, Potent Spirocyclic Series of¿-Secretase Inhibitors. |
Merck Research Laboratories |
| 26288679 |
12 |
Fused Morphlinopyrimidines and Methods of Use Thereof. |
Temple University |
| 26142947 |
77 |
Potent benzoazepinone¿-secretase modulators with improved bioavailability. |
Merck Research Laboratories |
| 25582600 |
22 |
Discovery of indole-derived pyridopyrazine-1,6-dione¿-secretase modulators that target presenilin. |
Pfizer |
| 26005540 |
14 |
Design of Pyridopyrazine-1,6-dione¿-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability. |
Pfizer |
| 25575659 |
124 |
SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease. |
Goethe-University Frankfurt |
| 24881566 |
140 |
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). |
Glaxosmithkline |
| 25454273 |
52 |
Anilinotriazoles as potent gamma secretase modulators. |
Janssen Pharmaceutica |
| 23707256 |
62 |
Membrane anchoring¿-secretase modulators with terpene-derived moieties. |
Technische Universit£T Darmstadt |
| 24900404 |
27 |
Discovery of SCH 900229, a Potent Presenilin 1 Selective ¿-Secretase Inhibitor for the Treatment of Alzheimer's Disease. |
TBA |
| 15588083 |
66 |
Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase. |
Harvard Medical School |
| 15050631 |
21 |
Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics. |
Harvard Medical School |
| 17573346 |
2 |
Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. |
Emmy Noether Research Group |
| 16766183 |
24 |
Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors. |
University of Tokyo |
| 16682202 |
14 |
3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity. |
Merck Sharp and Dohme Research Laboratories |
| 16682195 |
37 |
Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. |
University of Tokyo |
| 16617016 |
13 |
3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors. |
Neuroscience Research Centre |
| 16054361 |
17 |
Cyclic sulfamide gamma-secretase inhibitors. |
Merck Sharp and Dohme Research Laboratories |
| 15863342 |
21 |
Aryl sulfones: a new class of gamma-secretase inhibitors. |
Merck Sharp & Dohme Research Laboratories |
| 15603957 |
62 |
A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core. |
Merck Sharp & Dohme Research Laboratories |
| 15267231 |
17 |
Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. |
Harvard Medical School |
| 14592525 |
18 |
High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors. |
Merck Sharp & Dohme Research Laboratories |
| 12643944 |
26 |
Inhibitors of Abeta production: solid-phase synthesis and SAR of alpha-hydroxycarbonyl derivatives. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 32786237 |
39 |
Generation of Leads for ?-Secretase Modulation. |
Merck |
| 32307259 |
19 |
Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for ?-secretase modulators with oral efficacy against cognitive deficits in Alzheimer's disease model mice. |
Astellas Pharma |
| 32706964 |
39 |
Stepwise Design of ?-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere. |
F. Hoffmann-La Roche |
| 32551009 |
43 |
Discovery of RO7185876, a Highly Potent ?-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease. |
F. Hoffmann-La Roche |
| 31767402 |
21 |
Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active ?-secretase modulators. |
Astellas Pharma |
| 27007185 |
36 |
Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon? |
Forum Pharmaceuticals |
| 27426299 |
50 |
Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. |
University of California |
| 27045975 |
34 |
Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. |
Centre Hospitalier Universitaire Vaudois (Chuv) |
| 31122869 |
40 |
Design and synthesis of a novel series of cyanoindole derivatives as potent ?-secretase modulators. |
Janssen Research & Development |
| 30655935 |
8 |
Bridged Piperidine Derivatives Useful as ?-Secretase Inhibitors for the Treatment of Alzheimer's Disease. |
Temple University |
| 31531191 |
10 |
Triazolo Pyridines Useful as Inhibitors of ?-Secretase and Their Methods of Use. |
Temple University |
| 31531188 |
14 |
Triazolo-azepine Inhibitors of ?-Secretase and Their Methods of Use. |
Temple University |
| 27020305 |
5 |
Part 2. Notch-sparing ?-secretase inhibitors: The study of novel ?-amino naphthyl alcohols. |
Harvard Medical School |
| 26212776 |
69 |
Discovery of novel triazolobenzazepinones as ?-secretase modulators with central A?42 lowering in rodents and rhesus monkeys. |
Merck Research Laboratories Boston |
| 24914408 |
6 |
Development of CBAP-BPyne, a probe for ?-secretase and presenilinase. |
Memorial Sloan-Kettering Cancer Center |
| 24900755 |
3 |
Gamma secretase modulators. |
Montclair State University |
| 23312944 |
38 |
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious ?-secretase inhibitors. |
Elan Pharmaceuticals |
| 23342950 |
35 |
Effect of helical conformation and side chain structure on ?-secretase inhibition by ?-peptide foldamers: insight into substrate recognition. |
Nagoya City University |
| 23265902 |
48 |
A-ring modification of SCH 900229 and related chromene sulfone ?-secretase inhibitors. |
Merck Research Laboratories |
| 23265892 |
54 |
Structure activity relationship studies of tricyclic bispyran sulfone ?-secretase inhibitors. |
Merck Research Laboratories |
| 24900409 |
43 |
Synthesis and SAR Studies of Fused Oxadiazines as ?-Secretase Modulators for Treatment of Alzheimer's Disease. |
Merck Research Laboratory |
| 23046960 |
2 |
2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as ?-secretase inhibitors. |
Bristol-Myers Squibb R&D |
| 24900406 |
2 |
Initial Optimization of a New Series of ?-Secretase Modulators Derived from a Triterpene Glycoside. |
Satori Pharmaceuticals |
| 22420884 |
21 |
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active ?-secretase inhibitor. |
Pfizer |
| 22483609 |
52 |
Lead optimization of 4,4-biaryl piperidine amides as ?-secretase inhibitors. |
Merck Research Laboratories |
| 22418280 |
5 |
Development of clickable active site-directed photoaffinity probes for ?-secretase. |
Memorial Sloan-Kettering Cancer Center |
| 21995460 |
23 |
Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as ?-secretase inhibitors. |
Pfizer |
| 21885276 |
46 |
Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent ?-secretase inhibitors. |
Elan Pharmaceuticals |
| 21763147 |
64 |
NSAID-derived ?-secretase modulation requires an acidic moiety on the carbazole scaffold. |
Technische Universit£T Darmstadt |
| 21742495 |
40 |
Pyridine-derived ?-secretase modulators. |
Glaxosmithkline Pharmaceuticals |
| 21636276 |
40 |
Pyridazine-derived ?-secretase modulators. |
Glaxosmithkline Pharmaceuticals |
| 21269827 |
29 |
Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as ?-secretase inhibitors: discovery of PF-3084014. |
Pfizer |
| 21269825 |
50 |
Diamide amino-imidazoles: a novel series of ?-secretase inhibitors for the treatment of Alzheimer's disease. |
Pfizer |
| 21195610 |
35 |
Discovery of fused 5,6-bicyclic heterocycles as ?-secretase modulators. |
Merck Research Laboratories |
| 20724152 |
40 |
Iminoheterocycles as gamma-secretase modulators. |
Merck Research Laboratories |
| 20650635 |
12 |
Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library. |
Okayama University Graduate School of Medicine |
| 20529683 |
45 |
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II). |
Elan Pharmaceuticals |
| 20207146 |
7 |
Purine derivatives as potent gamma-secretase modulators. |
Merck Research Laboratories |
| 20207136 |
71 |
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors. |
Elan Pharmaceuticals |
| 19879754 |
57 |
NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring. |
Technische Universit£T Darmstadt |
| 20056541 |
83 |
Piperidine-derived gamma-secretase modulators. |
Glaxosmithkline |
| 20022243 |
8 |
Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators. |
Merck Research Laboratories |
| 20005099 |
22 |
Fluorinated piperidine acetic acids as gamma-secretase modulators. |
Merck Research Laboratories |
| 19879755 |
33 |
N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase. |
Elan Pharmaceuticals |
| 19660943 |
48 |
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors. |
Elan Pharmaceuticals |
| 19443228 |
1 |
Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors. |
Wyeth Research |
| 19432431 |
19 |
Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity. |
Merck Sharp & Dohme Research Laboratories |
| 19097779 |
2 |
Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors. |
Memorial Sloan-Kettering Cancer Center |
| 17932033 |
14 |
Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology. |
Bristol-Myers Squibb Research and Development |
| 17983746 |
31 |
Substituted 2-oxo-azepane derivatives are potent, orally active gamma-secretase inhibitors. |
F. Hoffmann-La Roche |
| 18061448 |
16 |
Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors. |
Merck Sharp and Dohme Research Laboratories |
| 18023581 |
39 |
Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase. |
Bristol-Myers Squibb |
| 17869509 |
57 |
Amino-caprolactam derivatives as gamma-secretase inhibitors. |
Bristol-Myers Squibb Research and Development |
| 17723298 |
28 |
Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor. |
Darmstadt University of Technology |
| 17502137 |
29 |
Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 17079141 |
54 |
Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease. |
Schering-Plough Research Institute |
| 17046254 |
24 |
Tetrahydroquinoline sulfonamides as gamma-secretase inhibitors. |
Schering-Plough Research Institute |
| 17035010 |
46 |
N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase. |
Darmstadt University of Technology |
| 17869099 |
37 |
Novel orally active, dibenzazepinone-based gamma-secretase inhibitors. |
F. Hoffmann-La Roche |
| 17764937 |
106 |
Thiazole-diamides as potent gamma-secretase inhibitors. |
Pfizer |
| 17606371 |
47 |
N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors. |
Bristol-Myers Squibb Research and Development |
| 17502143 |
49 |
Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent gamma-secretase inhibitors. |
Bristol-Myers Squibb |
| 17055268 |
33 |
2,6-Disubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors. |
Schering-Plough Research Institute |
| 29670685 |
10 |
Azabicyclic Fused Pyrimidine Derivatives Useful for the Treatment of Alzheimer's Disease. |
Temple University |
| 29541352 |
6 |
Azabicyclic Fused Pyrimidine Derivatives Useful for the Treatment of Alzheimer's Disease. |
Temple University |
| 29477076 |
24 |
Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead. |
Banaras Hindu University |
| 29249626 |
12 |
Discovery of novel scaffolds for ?-secretase modulators without an arylimidazole moiety. |
Astellas Pharma |
| 29057041 |
17 |
Discovery of a Tetrahydrobenzisoxazole Series of ?-Secretase Modulators. |
Merck Research Laboratories |
| 29735425 |
45 |
Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators. |
Boehringer Ingelheim Pharma |
| 18178084 |
24 |
Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase. |
Bristol-Myers Squibb |
| 16275079 |
29 |
4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors. |
Merck Research Laboratories |
| 18556202 |
37 |
Discovery of a novel series of Notch-sparing gamma-secretase inhibitors. |
Wyeth Research |
| 19012391 |
8 |
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. |
Wyeth Research |
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