Found 26 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125662
((S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-4-meth...)Show SMILES CC(C)C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(=O)Cc1ccccc1 Show InChI InChI=1S/C31H40F2N2O4/c1-20(2)13-27(34-29(37)18-23-14-24(32)19-25(33)15-23)31(39)35-26(16-21-9-5-3-6-10-21)30(38)28(36)17-22-11-7-4-8-12-22/h4,7-8,11-12,14-15,19-21,26-27,30,38H,3,5-6,9-10,13,16-18H2,1-2H3,(H,34,37)(H,35,39)/t26-,27-,30+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125656
((S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-4-meth...)Show SMILES CC(C)C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(C)=O Show InChI InChI=1S/C25H36F2N2O4/c1-15(2)9-22(28-23(31)13-18-10-19(26)14-20(27)11-18)25(33)29-21(24(32)16(3)30)12-17-7-5-4-6-8-17/h10-11,14-15,17,21-22,24,32H,4-9,12-13H2,1-3H3,(H,28,31)(H,29,33)/t21-,22-,24-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125670
((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)Show SMILES CC(C)CCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(=O)Cc1ccccc1 Show InChI InChI=1S/C29H46N2O4/c1-20(2)15-16-27(33)30-25(17-21(3)4)29(35)31-24(18-22-11-7-5-8-12-22)28(34)26(32)19-23-13-9-6-10-14-23/h6,9-10,13-14,20-22,24-25,28,34H,5,7-8,11-12,15-19H2,1-4H3,(H,30,33)(H,31,35)/t24-,25-,28+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125653
((S)-4-Methyl-2-phenylacetylamino-pentanoic acid ((...)Show SMILES CC(C)C[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(=O)Cc1ccccc1 Show InChI InChI=1S/C31H42N2O4/c1-22(2)18-27(32-29(35)21-25-16-10-5-11-17-25)31(37)33-26(19-23-12-6-3-7-13-23)30(36)28(34)20-24-14-8-4-9-15-24/h4-5,8-11,14-17,22-23,26-27,30,36H,3,6-7,12-13,18-21H2,1-2H3,(H,32,35)(H,33,37)/t26-,27-,30+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125658
((S)-2-[2-(3-Fluoro-phenyl)-acetylamino]-4-methyl-p...)Show SMILES CC(C)C[C@H](NC(=O)Cc1cccc(F)c1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(=O)Cc1ccccc1 Show InChI InChI=1S/C31H41FN2O4/c1-21(2)16-27(33-29(36)20-24-14-9-15-25(32)17-24)31(38)34-26(18-22-10-5-3-6-11-22)30(37)28(35)19-23-12-7-4-8-13-23/h4,7-9,12-15,17,21-22,26-27,30,37H,3,5-6,10-11,16,18-20H2,1-2H3,(H,33,36)(H,34,38)/t26-,27-,30+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125657
((2R,3S)-4-Cyclohexyl-3-{(S)-2-[2-(3,5-difluoro-phe...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1cc(F)cc(F)c1 Show InChI InChI=1S/C26H38F2N2O5/c1-4-35-26(34)24(32)21(13-17-8-6-5-7-9-17)30-25(33)22(10-16(2)3)29-23(31)14-18-11-19(27)15-20(28)12-18/h11-12,15-17,21-22,24,32H,4-10,13-14H2,1-3H3,(H,29,31)(H,30,33)/t21-,22-,24+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125666
((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)Show SMILES CC(C)CCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(=O)C(C)C Show InChI InChI=1S/C25H46N2O4/c1-16(2)12-13-22(28)26-21(14-17(3)4)25(31)27-20(24(30)23(29)18(5)6)15-19-10-8-7-9-11-19/h16-21,24,30H,7-15H2,1-6H3,(H,26,28)(H,27,31)/t20-,21-,24+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125659
((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)Show SMILES CCCC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)CCC(C)C Show InChI InChI=1S/C25H46N2O4/c1-6-10-22(28)24(30)20(16-19-11-8-7-9-12-19)27-25(31)21(15-18(4)5)26-23(29)14-13-17(2)3/h17-21,24,30H,6-16H2,1-5H3,(H,26,29)(H,27,31)/t20-,21-,24+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125677
((S)-4-Methyl-2-phenylacetylamino-pentanoic acid ((...)Show SMILES CCCC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1ccccc1 Show InChI InChI=1S/C27H42N2O4/c1-4-11-24(30)26(32)22(17-20-12-7-5-8-13-20)29-27(33)23(16-19(2)3)28-25(31)18-21-14-9-6-10-15-21/h6,9-10,14-15,19-20,22-23,26,32H,4-5,7-8,11-13,16-18H2,1-3H3,(H,28,31)(H,29,33)/t22-,23-,26+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125675
((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)Show SMILES CC(C)CCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(C)=O Show InChI InChI=1S/C23H42N2O4/c1-15(2)11-12-21(27)24-20(13-16(3)4)23(29)25-19(22(28)17(5)26)14-18-9-7-6-8-10-18/h15-16,18-20,22,28H,6-14H2,1-5H3,(H,24,27)(H,25,29)/t19-,20-,22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125672
((S)-4-Methyl-2-phenylacetylamino-pentanoic acid ((...)Show SMILES CC(C)C[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)C(=O)C(O)c1ccccc1 Show InChI InChI=1S/C30H40N2O4/c1-21(2)18-26(31-27(33)20-23-14-8-4-9-15-23)30(36)32-25(19-22-12-6-3-7-13-22)29(35)28(34)24-16-10-5-11-17-24/h4-5,8-11,14-17,21-22,25-26,28,34H,3,6-7,12-13,18-20H2,1-2H3,(H,31,33)(H,32,36)/t25-,26-,28?/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125664
((S)-4-Methyl-2-phenylacetylamino-pentanoic acid ((...)Show SMILES CC(C)C[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(C)=O Show InChI InChI=1S/C25H38N2O4/c1-17(2)14-22(26-23(29)16-20-12-8-5-9-13-20)25(31)27-21(24(30)18(3)28)15-19-10-6-4-7-11-19/h5,8-9,12-13,17,19,21-22,24,30H,4,6-7,10-11,14-16H2,1-3H3,(H,26,29)(H,27,31)/t21-,22-,24-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125654
((2R,3S)-4-Cyclohexyl-3-{(S)-2-[2-(3-fluoro-phenyl)...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1cccc(F)c1 Show InChI InChI=1S/C26H39FN2O5/c1-4-34-26(33)24(31)21(15-18-9-6-5-7-10-18)29-25(32)22(13-17(2)3)28-23(30)16-19-11-8-12-20(27)14-19/h8,11-12,14,17-18,21-22,24,31H,4-7,9-10,13,15-16H2,1-3H3,(H,28,30)(H,29,32)/t21-,22-,24+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125669
((2R,3S)-4-Cyclohexyl-2-hydroxy-3-[(S)-4-methyl-2-(...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)CCC(C)C Show InChI InChI=1S/C24H44N2O5/c1-6-31-24(30)22(28)19(15-18-10-8-7-9-11-18)26-23(29)20(14-17(4)5)25-21(27)13-12-16(2)3/h16-20,22,28H,6-15H2,1-5H3,(H,25,27)(H,26,29)/t19-,20-,22+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125668
((2R,3S)-4-Cyclohexyl-2-hydroxy-3-((S)-4-methyl-2-p...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1ccccc1 Show InChI InChI=1S/C26H40N2O5/c1-4-33-26(32)24(30)21(16-19-11-7-5-8-12-19)28-25(31)22(15-18(2)3)27-23(29)17-20-13-9-6-10-14-20/h6,9-10,13-14,18-19,21-22,24,30H,4-5,7-8,11-12,15-17H2,1-3H3,(H,27,29)(H,28,31)/t21-,22-,24+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125671
((2R,3S)-4-Cyclohexyl-3-{(S)-2-[2-(4-fluoro-phenyl)...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C26H39FN2O5/c1-4-34-26(33)24(31)21(15-18-8-6-5-7-9-18)29-25(32)22(14-17(2)3)28-23(30)16-19-10-12-20(27)13-11-19/h10-13,17-18,21-22,24,31H,4-9,14-16H2,1-3H3,(H,28,30)(H,29,32)/t21-,22-,24+/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD
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antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125655
((2R,3S)-4-Cyclohexyl-2-hydroxy-3-[(S)-3-methyl-2-(...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)C(=O)c1ccccc1)C(C)C Show InChI InChI=1S/C25H36N2O6/c1-4-33-25(32)22(29)19(15-17-11-7-5-8-12-17)26-23(30)20(16(2)3)27-24(31)21(28)18-13-9-6-10-14-18/h6,9-10,13-14,16-17,19-20,22,29H,4-5,7-8,11-12,15H2,1-3H3,(H,26,30)(H,27,31)/t19-,20-,22+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125674
((2R,3S)-4-Cyclohexyl-2-hydroxy-3-((S)-3-methyl-2-p...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)Cc1ccccc1)C(C)C Show InChI InChI=1S/C25H38N2O5/c1-4-32-25(31)23(29)20(15-18-11-7-5-8-12-18)26-24(30)22(17(2)3)27-21(28)16-19-13-9-6-10-14-19/h6,9-10,13-14,17-18,20,22-23,29H,4-5,7-8,11-12,15-16H2,1-3H3,(H,26,30)(H,27,28)/t20-,22-,23+/m0/s1 | PDB
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UniProtKB/SwissProt
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antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125652
((S)-4-Methyl-2-(4-methyl-pentanoylamino)-pentanoic...)Show SMILES CC(C)CCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1CCCCC1)C(=O)C(O)c1ccccc1 Show InChI InChI=1S/C28H44N2O4/c1-19(2)15-16-25(31)29-24(17-20(3)4)28(34)30-23(18-21-11-7-5-8-12-21)27(33)26(32)22-13-9-6-10-14-22/h6,9-10,13-14,19-21,23-24,26,32H,5,7-8,11-12,15-18H2,1-4H3,(H,29,31)(H,30,34)/t23-,24-,26?/m0/s1 | PDB
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UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125673
((2R,3S)-4-Cyclohexyl-2-hydroxy-3-{(S)-3-methyl-2-[...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)\C=C\c1ccccc1)C(C)C Show InChI InChI=1S/C26H38N2O5/c1-4-33-26(32)24(30)21(17-20-13-9-6-10-14-20)27-25(31)23(18(2)3)28-22(29)16-15-19-11-7-5-8-12-19/h5,7-8,11-12,15-16,18,20-21,23-24,30H,4,6,9-10,13-14,17H2,1-3H3,(H,27,31)(H,28,29)/b16-15+/t21-,23-,24+/m0/s1 | PDB
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UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125665
((2R,3S)-4-Cyclohexyl-2-hydroxy-3-((S)-3-phenyl-2-p...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccccc1 Show InChI InChI=1S/C29H38N2O5/c1-2-36-29(35)27(33)24(18-21-12-6-3-7-13-21)31-28(34)25(19-22-14-8-4-9-15-22)30-26(32)20-23-16-10-5-11-17-23/h4-5,8-11,14-17,21,24-25,27,33H,2-3,6-7,12-13,18-20H2,1H3,(H,30,32)(H,31,34)/t24-,25-,27+/m0/s1 | PDB
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UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125661
((2R,3S)-4-Cyclohexyl-2-hydroxy-3-((S)-4-methyl-2-p...)Show SMILES CC(C)C[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(O)=O Show InChI InChI=1S/C24H36N2O5/c1-16(2)13-20(25-21(27)15-18-11-7-4-8-12-18)23(29)26-19(22(28)24(30)31)14-17-9-5-3-6-10-17/h4,7-8,11-12,16-17,19-20,22,28H,3,5-6,9-10,13-15H2,1-2H3,(H,25,27)(H,26,29)(H,30,31)/t19-,20-,22+/m0/s1 | PDB
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AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125663
((2R,3S)-4-Cyclohexyl-3-{(S)-2-[2-(2-fluoro-phenyl)...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)Cc1ccccc1F)C(C)C Show InChI InChI=1S/C25H37FN2O5/c1-4-33-25(32)23(30)20(14-17-10-6-5-7-11-17)27-24(31)22(16(2)3)28-21(29)15-18-12-8-9-13-19(18)26/h8-9,12-13,16-17,20,22-23,30H,4-7,10-11,14-15H2,1-3H3,(H,27,31)(H,28,29)/t20-,22-,23+/m0/s1 | PDB
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125660
((2R,3S)-3-((S)-2-Benzoylamino-3-methyl-butyrylamin...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)C Show InChI InChI=1S/C24H36N2O5/c1-4-31-24(30)21(27)19(15-17-11-7-5-8-12-17)25-23(29)20(16(2)3)26-22(28)18-13-9-6-10-14-18/h6,9-10,13-14,16-17,19-21,27H,4-5,7-8,11-12,15H2,1-3H3,(H,25,29)(H,26,28)/t19-,20-,21+/m0/s1 | PDB
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125667
((2R,3S)-4-Cyclohexyl-2-hydroxy-3-{(S)-3-methyl-2-[...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)C1(CC1)c1ccccc1)C(C)C Show InChI InChI=1S/C27H40N2O5/c1-4-34-25(32)23(30)21(17-19-11-7-5-8-12-19)28-24(31)22(18(2)3)29-26(33)27(15-16-27)20-13-9-6-10-14-20/h6,9-10,13-14,18-19,21-23,30H,4-5,7-8,11-12,15-17H2,1-3H3,(H,28,31)(H,29,33)/t21-,22-,23+/m0/s1 | PDB
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50125676
((2R,3S)-4-Cyclohexyl-2-hydroxy-3-((R)-3-methyl-2-p...)Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](NC(=O)Cc1ccccc1)C(C)C Show InChI InChI=1S/C25H38N2O5/c1-4-32-25(31)23(29)20(15-18-11-7-5-8-12-18)26-24(30)22(17(2)3)27-21(28)16-19-13-9-6-10-14-19/h6,9-10,13-14,17-18,20,22-23,29H,4-5,7-8,11-12,15-16H2,1-3H3,(H,26,30)(H,27,28)/t20-,22+,23+/m0/s1 | PDB
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UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. |
Bioorg Med Chem Lett 13: 1203-6 (2003)
BindingDB Entry DOI: 10.7270/Q279442Z |
More data for this
Ligand-Target Pair | |
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