59 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
26820555	87	Synthesis and evaluation of colletoic acid core derivatives.	St. Jude Children'S Research Hospital
26187704	63	Discovery of 11ß-hydroxysteroid dehydrogenase type 1 inhibitor.	Incheon National University
25590374	23	Hupehenols A-E, selective 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors from Viburnum hupehense.	Chinese Academy Of Sciences
25800116	62	Synthesis and optimization of picolinamide derivatives as a novel class of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors.	Seoul National University
25050169	52	Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).	Bristol-Myers Squibb
24294985	42	Medicinal chemistry of inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1).	Astrazeneca
24074876	17	Synthesis of sterically encumbered 11ß-aminoprogesterone derivatives and evaluation as 11ß-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists.	University Of Alberta
23747808	51	Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11ß-HSD1 inhibitors: potential impact in diabetes.	Chinese Academy Of Sciences
23659858	17	Evaluation of selective inhibitors of 11ß-HSD1 for the treatment of hypertension.	Merck
23478147	42	Discovery of SAR184841, a potent and long-lasting inhibitor of 11ß-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.	Sanofi R & D
24900572	54	Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.	Pfizer
23153367	92	Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors.	Astrazeneca
23088558	36	Novel acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).	Astrazeneca
23013933	59	Optimisation of pharmacokinetic properties in a neutral series of 11ß-HSD1 inhibitors.	Astrazeneca
24900382	41	Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitors.	TBA
22691057	32	Discovery of a potent, selective, and orally bioavailable acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).	Astrazeneca
22901389	28	Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11ß-hydroxysteroid dehydrogenase type I.	Merck Serono
22360639	12	Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11ß-hydroxysteroid dehydrogenases.	Chinese Academy Of Sciences
22440625	44	Synthesis and evaluation of piperidine urea derivatives as efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.	Chinese Academy Of Sciences
19564108	48	4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.	Chinese Academy Of Sciences
18553955	43	Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.	Amgen
18440812	113	Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.	Merck Research Laboratories
18434143	96	Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.	Merck
17490884	39	beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action.	Wyeth Research
22148241	3	Cyclopeptide Alkaloids from Ziziphus apetala.	Kunming Institute Of Botany
21983444	78	Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1).	Bristol-Myers Squibb Research & Development
21873057	13	Potent and novel 11ß-HSD1 inhibitors identified from shape and docking based virtual screening.	Shanghai Pharmaceutical Holding
21786805	130	Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11ß-hydroxysteroid dehydrogenase type 1.	Vitae Pharmaceuticals
21689935	55	Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1).	Bristol-Myers Squibb
21334894	218	Substituted phenyl triazoles as selective inhibitors of 11 β-Hydroxysteroid Dehydrogenase Type 1.	Merck
21439819	49	Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1.	Sanofi-Aventis R&D
21421311	135	Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome.	Merck Research Laboratories
21376605	26	Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11ß-hydroxysteroid dehydrogenase 2 inhibitors.	University Of Technology
20864344	110	Discovery and optimization of adamantyl carbamate inhibitors of 11ß-HSD1.	Vitae Pharmaceuticals
20851614	22	Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11ß-hydroxysteroid dehydrogenase 2 inhibitors.	University Of Natural Resources And Applied Life Sciences
20465278	27	Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221).	Amgen
20363126	50	The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.	Pfizer
20064717	64	Spirocyclic ureas: orally bioavailable 11beta-HSD1 inhibitors identified by computer-aided drug design.	Vitae Pharmaceuticals
19395260	29	Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.	Merck Serono
19181519	71	Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).	TBA
19053753	67	Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.	Amgen
18440811	207	4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.	Merck Research Laboratories
17919905	56	The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.	Amgen
17600707	48	Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.	Biovitrum
17442567	27	Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.	Biovitrum
17201418	105	Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.	Abbott Laboratories
17070044	102	Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.	Abbott Laboratories
17000111	127	Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome.	Abbott Laboratories
16996734	93	Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.	Abbott Laboratories
16931002	73	Discovery of orally active butyrolactam 11beta-HSD1 inhibitors.	Abbott Laboratories
16899366	85	Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.	Abbott Laboratories
16890427	81	Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.	Abbott Laboratories
16759088	38	The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.	University Of Innsbruck
16185866	53	Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome.	Merck
15911270	19	Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.	Wyeth Research
21337480	17	Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans.	The University Of Edinburgh
20187655	12	Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.	Academia Sinica