Found 27 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210886
(1-(1-(3,4-dimethylbenzoyl)piperidin-4-yl)-1H-benzo...)Show SMILES Cc1ccc(cc1C)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C21H23N3O2/c1-14-7-8-16(13-15(14)2)20(25)23-11-9-17(10-12-23)24-19-6-4-3-5-18(19)22-21(24)26/h3-8,13,17H,9-12H2,1-2H3,(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210884
(1-(1-(3-methoxy-4-methylbenzoyl)piperidin-4-yl)-1H...)Show SMILES COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C21H23N3O3/c1-14-7-8-15(13-19(14)27-2)20(25)23-11-9-16(10-12-23)24-18-6-4-3-5-17(18)22-21(24)26/h3-8,13,16H,9-12H2,1-2H3,(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210892
(1-(1-(3-methoxy-4-methylbenzoyl)piperidin-4-yl)-4-...)Show SMILES COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2cccc(C)c2[nH]c1=O Show InChI InChI=1S/C22H25N3O3/c1-14-7-8-16(13-19(14)28-3)21(26)24-11-9-17(10-12-24)25-18-6-4-5-15(2)20(18)23-22(25)27/h4-8,13,17H,9-12H2,1-3H3,(H,23,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210890
(3-(1-(3-methoxy-4-methylbenzoyl)piperidin-4-yl)ben...)Show SMILES COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2ccccc2sc1=O Show InChI InChI=1S/C21H22N2O3S/c1-14-7-8-15(13-18(14)26-2)20(24)22-11-9-16(10-12-22)23-17-5-3-4-6-19(17)27-21(23)25/h3-8,13,16H,9-12H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210901
(1-(1-(3-methoxy-4-methylbenzoyl)piperidin-4-yl)-3-...)Show SMILES COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2ccccc2n(C)c1=O Show InChI InChI=1S/C22H25N3O3/c1-15-8-9-16(14-20(15)28-3)21(26)24-12-10-17(11-13-24)25-19-7-5-4-6-18(19)23(2)22(25)27/h4-9,14,17H,10-13H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210899
(1-(1-(4-amino-3-methoxybenzoyl)piperidin-4-yl)-1H-...)Show SMILES COc1cc(ccc1N)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C20H22N4O3/c1-27-18-12-13(6-7-15(18)21)19(25)23-10-8-14(9-11-23)24-17-5-3-2-4-16(17)22-20(24)26/h2-7,12,14H,8-11,21H2,1H3,(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210895
(5-fluoro-1-(1-(3-methoxy-4-methylbenzoyl)piperidin...)Show SMILES COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2ccc(F)cc2[nH]c1=O Show InChI InChI=1S/C21H22FN3O3/c1-13-3-4-14(11-19(13)28-2)20(26)24-9-7-16(8-10-24)25-18-6-5-15(22)12-17(18)23-21(25)27/h3-6,11-12,16H,7-10H2,1-2H3,(H,23,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210902
(1-(1-(3-methoxy-4-methylbenzoyl)piperidin-4-yl)ind...)Show SMILES COc1cc(ccc1C)C(=O)N1CCC(CC1)N1C(=O)Cc2ccccc12 Show InChI InChI=1S/C22H24N2O3/c1-15-7-8-17(13-20(15)27-2)22(26)23-11-9-18(10-12-23)24-19-6-4-3-5-16(19)14-21(24)25/h3-8,13,18H,9-12,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210898
(3-(1-(3-methoxy-4-methylbenzoyl)piperidin-4-yl)ben...)Show SMILES COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2ccccc2oc1=O Show InChI InChI=1S/C21H22N2O4/c1-14-7-8-15(13-19(14)26-2)20(24)22-11-9-16(10-12-22)23-17-5-3-4-6-18(17)27-21(23)25/h3-8,13,16H,9-12H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210888
(1-(1-(3-methoxybenzoyl)piperidin-4-yl)-1H-benzo[d]...)Show SMILES COc1cccc(c1)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C20H21N3O3/c1-26-16-6-4-5-14(13-16)19(24)22-11-9-15(10-12-22)23-18-8-3-2-7-17(18)21-20(23)25/h2-8,13,15H,9-12H2,1H3,(H,21,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210905
(1-(1-(3-methoxy-4-methylbenzoyl)piperidin-4-yl)-4,...)Show SMILES COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2ccc(C)c(C)c2[nH]c1=O Show InChI InChI=1S/C23H27N3O3/c1-14-6-8-19-21(16(14)3)24-23(28)26(19)18-9-11-25(12-10-18)22(27)17-7-5-15(2)20(13-17)29-4/h5-8,13,18H,9-12H2,1-4H3,(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210904
(5-chloro-1-(1-(3-methoxy-4-methylbenzoyl)piperidin...)Show SMILES COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2ccc(Cl)cc2n(C)c1=O Show InChI InChI=1S/C22H24ClN3O3/c1-14-4-5-15(12-20(14)29-3)21(27)25-10-8-17(9-11-25)26-18-7-6-16(23)13-19(18)24(2)22(26)28/h4-7,12-13,17H,8-11H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210896
(1-(1-(2-chloro-4-methoxypicolinoyl)piperidin-4-yl)...)Show SMILES COc1cc(Cl)nc(c1)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C19H19ClN4O3/c1-27-13-10-15(21-17(20)11-13)18(25)23-8-6-12(7-9-23)24-16-5-3-2-4-14(16)22-19(24)26/h2-5,10-12H,6-9H2,1H3,(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210894
(5-chloro-1-(1-(3-methoxy-4-methylbenzoyl)piperidin...)Show SMILES COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O Show InChI InChI=1S/C21H22ClN3O3/c1-13-3-4-14(11-19(13)28-2)20(26)24-9-7-16(8-10-24)25-18-6-5-15(22)12-17(18)23-21(25)27/h3-6,11-12,16H,7-10H2,1-2H3,(H,23,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210903
(1-(1-(benzofuran-6-carbonyl)piperidin-4-yl)-1H-ben...)Show SMILES O=C(N1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc2ccoc2c1 Show InChI InChI=1S/C21H19N3O3/c25-20(15-6-5-14-9-12-27-19(14)13-15)23-10-7-16(8-11-23)24-18-4-2-1-3-17(18)22-21(24)26/h1-6,9,12-13,16H,7-8,10-11H2,(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210887
(1-(1-(2,3-dimethylbenzoyl)piperidin-4-yl)-1H-benzo...)Show SMILES Cc1cccc(C(=O)N2CCC(CC2)n2c3ccccc3[nH]c2=O)c1C Show InChI InChI=1S/C21H23N3O2/c1-14-6-5-7-17(15(14)2)20(25)23-12-10-16(11-13-23)24-19-9-4-3-8-18(19)22-21(24)26/h3-9,16H,10-13H2,1-2H3,(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210897
(1-(1-(benzo[d][1,3]dioxole-6-carbonyl)piperidin-4-...)Show SMILES O=C(N1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc2OCOc2c1 Show InChI InChI=1S/C20H19N3O4/c24-19(13-5-6-17-18(11-13)27-12-26-17)22-9-7-14(8-10-22)23-16-4-2-1-3-15(16)21-20(23)25/h1-6,11,14H,7-10,12H2,(H,21,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210882
(1-(1-(2-(trifluoromethyl)benzoyl)piperidin-4-yl)-1...)Show SMILES FC(F)(F)c1ccccc1C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C20H18F3N3O2/c21-20(22,23)15-6-2-1-5-14(15)18(27)25-11-9-13(10-12-25)26-17-8-4-3-7-16(17)24-19(26)28/h1-8,13H,9-12H2,(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210889
(1-(1-(4-tert-butylbenzoyl)piperidin-4-yl)-1H-benzo...)Show SMILES CC(C)(C)c1ccc(cc1)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C23H27N3O2/c1-23(2,3)17-10-8-16(9-11-17)21(27)25-14-12-18(13-15-25)26-20-7-5-4-6-19(20)24-22(26)28/h4-11,18H,12-15H2,1-3H3,(H,24,28) | PDB
MMDB
Reactome pathway
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UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210885
(1-(1-(3-fluoro-4-methylbenzoyl)piperidin-4-yl)-1H-...)Show SMILES Cc1ccc(cc1F)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C20H20FN3O2/c1-13-6-7-14(12-16(13)21)19(25)23-10-8-15(9-11-23)24-18-5-3-2-4-17(18)22-20(24)26/h2-7,12,15H,8-11H2,1H3,(H,22,26) | PDB
MMDB
Reactome pathway
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PC sid
UniChem
Similars
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PubMed
| 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210891
(1-(1-(4-(trifluoromethyl)benzoyl)piperidin-4-yl)-1...)Show SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C20H18F3N3O2/c21-20(22,23)14-7-5-13(6-8-14)18(27)25-11-9-15(10-12-25)26-17-4-2-1-3-16(17)24-19(26)28/h1-8,15H,9-12H2,(H,24,28) | PDB
MMDB
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PC sid
UniChem
Similars
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PubMed
| 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210881
(1-(1-(3-(trifluoromethyl)benzoyl)piperidin-4-yl)-1...)Show SMILES FC(F)(F)c1cccc(c1)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C20H18F3N3O2/c21-20(22,23)14-5-3-4-13(12-14)18(27)25-10-8-15(9-11-25)26-17-7-2-1-6-16(17)24-19(26)28/h1-7,12,15H,8-11H2,(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
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PC cid
PC sid
UniChem
Similars
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PubMed
| 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210900
(1-(1-(2-fluorobenzoyl)piperidin-4-yl)-1H-benzo[d]i...)Show InChI InChI=1S/C19H18FN3O2/c20-15-6-2-1-5-14(15)18(24)22-11-9-13(10-12-22)23-17-8-4-3-7-16(17)21-19(23)25/h1-8,13H,9-12H2,(H,21,25) | PDB
MMDB
Reactome pathway
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PC sid
UniChem
Similars
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PubMed
| 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210893
(1-(1-pivaloylpiperidin-4-yl)-1H-benzo[d]imidazol-2...)Show InChI InChI=1S/C17H23N3O2/c1-17(2,3)15(21)19-10-8-12(9-11-19)20-14-7-5-4-6-13(14)18-16(20)22/h4-7,12H,8-11H2,1-3H3,(H,18,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase type 2
(Homo sapiens (Human)) | BDBM50210884
(1-(1-(3-methoxy-4-methylbenzoyl)piperidin-4-yl)-1H...)Show SMILES COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C21H23N3O3/c1-14-7-8-15(13-19(14)27-2)20(25)23-11-9-16(10-12-23)24-18-6-4-3-5-17(18)22-21(24)26/h3-8,13,16H,9-12H2,1-2H3,(H,22,26) | KEGG
UniProtKB/SwissProt
DrugBank
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of 11betaHSD2 |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210883
(1-(1-(cyclohexanecarbonyl)piperidin-4-yl)-1H-benzo...)Show InChI InChI=1S/C19H25N3O2/c23-18(14-6-2-1-3-7-14)21-12-10-15(11-13-21)22-17-9-5-4-8-16(17)20-19(22)24/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,20,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50210906
(1-(1-(furan-2-carbonyl)piperidin-4-yl)-1H-benzo[d]...)Show InChI InChI=1S/C17H17N3O3/c21-16(15-6-3-11-23-15)19-9-7-12(8-10-19)20-14-5-2-1-4-13(14)18-17(20)22/h1-6,11-12H,7-10H2,(H,18,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biovitrum AB
Curated by ChEMBL
| Assay Description
Inhibition of human 11betaHSD1 by SPA |
Bioorg Med Chem Lett 17: 3421-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.083
BindingDB Entry DOI: 10.7270/Q2GX4B72 |
More data for this
Ligand-Target Pair | |
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