104 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
10340605	5	Synthesis and evaluation of geldanamycin-estradiol hybrids.	Sloan-Kettering Institute For Cancer Research
26395057	48	From carbohydrates to drug-like fragments: Rational development of novela-amylase inhibitors.	Freie Universit£T Berlin
26112442	74	Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors.	Chengdu University of Tcm
25799158	6	Volume of Distribution in Drug Design.	Pharmacokinetics
25901531	211	Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.	Sloan-Kettering Institute For Cancer Research
24984936	28	Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.	Tufts University
24980703	296	Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.	Nerviano Medical Sciences
24745965	22	Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors.	Montclair State University
24580531	6	Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.	University of Geneva
24763261	35	Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening.	China Pharmaceutical University
24673104	185	Identification of novel HSP90a/ß isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.	Vertex Pharmaceuticals
23394126	170	Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).	Exelixis
23186287	1	Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.	Seoul National University
22835870	29	Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.	Astrazeneca
23018093	41	Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.	Vernalis
22632933	65	Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.	Merck Serono
22386527	23	Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.	Serenex
20055425	29	Heat shock protein 90: inhibitors in clinical trials.	Biogen Idec
19405528	45	Potent cytotoxic C-11 modified geldanamycin analogues.	Kosan Biosciences
19017562	45	Discovery and development of heat shock protein 90 inhibitors.	Memorial Sloan-Kettering Cancer Center
16854066	44	Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.	Infinity Pharmaceuticals
22066525	65	Novel 3,4-isoxazolediamides as potent inhibitors of chaperone heat shock protein 90.	Universit£
22014826	3	A small molecule that preferentially binds the closed conformation of Hsp90.	San Diego State University
21972823	10	Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone.	Sanofi-Aventis Research and Development
21920765	12	Lead identification ofß-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.	Trinity College
20608738	7	ATPases as drug targets: insights from heat shock proteins 70 and 90.	Vernalis R&D
19331414	1	Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin.	Trinity College
18457385	41	Recent developments in fragment-based drug discovery.	Astex Therapeutics
16621545	6	Synthesis of Hsp90 dimerization modulators.	Memorial Sloan-Kettering Cancer Center
16530412	13	High-throughput screening for Hsp90 ATPase inhibitors.	The University of Kansas
16480864	38	4-Amino derivatives of the Hsp90 inhibitor CCT018159.	Vernalis
16392823	39	Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.	Memorial Sloan-Kettering Cancer Center
15828828	136	Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.	Memorial Sloan-Kettering Cancer Center
15239664	92	Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.	Conforma Therapeutics
14698151	14	Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures.	Ribotargets
14592488	2	Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.	Memorial Sloan-Kettering Cancer Center
32305165	72	Discovery of novel heat shock protein (Hsp90) inhibitors based on luminespib with potent antitumor activity.	Seoul National University
32222339	5	Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities.	Fujian Medical University (Fmu)
32832020	1	From Bacteria to Cancer: A Benzothiazole-Based DNA Gyrase B Inhibitor Redesigned for Hsp90 C-Terminal Inhibition.	The University of Notre Dame
32527461	1	Enzymatic biosynthesis and biological evaluation of novel 17-AAG glucoside as potential anti-cancer agents.	Bengbu Medical College
32324396	17	p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators.	China Pharmaceutical University
27312008	4	Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles.	Universit£
26844689	22	Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions.	Chinese Academy of Sciences
30597326	50	High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity.	Jiangsu Normal University
31663736	15	Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.	China Pharmaceutical University
31469962	122	Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors.	Korea University
31935086	19	Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer.	China Pharmaceutical University
30769242	14	Clinical candidates modulating protein-protein interactions: The fragment-based experience.	Taros Chemicals
31188592	39	Why Some Targets Benefit from beyond Rule of Five Drugs.	Boston University
30048133	1	Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design.	Istituto Di Chimica Del Riconoscimento Molecolare
31519378	1	C-terminal modulators of heat shock protein of 90?kDa (HSP90): State of development and modes of action.	Heinrich Heine University D£Sseldorf
27818030	5	Optimization and bioevaluation of Cdc37-derived peptides: An insight into Hsp90-Cdc37 protein-protein interaction modulators.	China Pharmaceutical University
25141341	1	Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors.	Montclair State University
24582477	33	Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold.	China Pharmaceutical University
24548207	14	Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.	Memorial Sloan-Kettering Cancer Center
24495105	1	Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells.	University of California
23859777	5	Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors.	University of Arizona
23770448	19	Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors.	University of Salerno
23520985	12	Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening.	Universit£
23606927	11	3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues.	The University of Kansas
22877636	60	Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90.	Exelixis
22913511	91	Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor.	Myrexis
21486005	3	Gambogic acid, a natural product inhibitor of Hsp90.	Oklahoma State University
21612924	10	Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone.	Pfizer
20718493	29	Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.	Astex Therapeutics
20655237	8	Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.	Universit£
20570149	4	Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues.	The University of Kansas
19908836	11	Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.	Pfizer
19395259	28	Discovery of 5-substituted 2-amino-4-chloro-8-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6(5H)-ones as potent and selective Hsp90 inhibitors.	Poniard Pharmaceuticals
19552433	49	Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.	Serenex
18929486	41	Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.	Pfizer
19101151	34	Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.	The University of Kansas
18762423	20	Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay.	Emory University
18571929	45	Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.	Emory University
18020309	1	Derrubone, an inhibitor of the Hsp90 protein folding machinery.	The University of Kansas
29545103	27	Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90).	National University of Singapore
29701469	52	Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.	University of Vienna
30351001	16	Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.	China Pharmaceutical University
28482218	3	Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction.	China Pharmaceutical University
22591317	5	Impacts of some antibiotics on human serum paraoxonase 1 activity.	Atatürk University
14610240	8	Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB).	National Institutes of Health
10832613	26	[3H]S33084: a novel, selective and potent radioligand at cloned, human dopamine D3 receptors.	Croissy-Sur-Seine Paris