The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 410930 |
15 |
Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship. |
TBA |
| 409842 |
24 |
Methotrexate analogues. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogues. |
TBA |
| 114660 |
8 |
5-Cyano-2'-deoxyuridine 5'-phosphate: a potent competitive inhibitor of thymidylate synthetase. |
TBA |
| 109616 |
9 |
Methotrexate analogues. 12. Synthesis and biological properties of some aza homologues. |
TBA |
| 423172 |
1 |
Phosphonate analogue of 2'-deoxy-5-fluorouridylic acid. |
TBA |
| 110931 |
2 |
Synthesis of 5-selenium-substituted uracil derivatives. Inhibition of thymidylate synthetase by 5-hydroseleno-2'-deoxyuridylate. |
TBA |
| 106122 |
3 |
Enzyme affinity of the 5,6-dihydro derivatives of the substrate and product of thymidylate synthetase catalysis. |
TBA |
| 24147825 |
22 |
2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives. |
University Of Modena And Reggio Emilia |
| 6772788 |
8 |
Folate analogues altered in the C9-N10 bridge region. 16. Synthesis and antifolate activity of 11-thiohomoaminopterin. |
TBA |
| 15615538 |
28 |
Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
Duquesne University |
| 16078850 |
41 |
Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
Duquesne University |
| 15214773 |
76 |
Fragment-based drug discovery. |
Sunesis Pharmaceuticals |
| 8201595 |
12 |
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids. |
Eisai |
| 3373483 |
39 |
Linear free energy relationship studies of enzyme active site binding: thymidylate synthase. |
University Of Kansas |
| 3121855 |
21 |
Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative. |
Sri International |
| 3470522 |
16 |
Folate analogues as inhibitors of thymidylate synthase. |
TBA |
| 3091832 |
28 |
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF). |
TBA |
| 3100797 |
21 |
Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives. |
TBA |
| 3027327 |
3 |
Spin probes as mechanistic inhibitors and active site probes of thymidylate synthetase. |
TBA |
| 2423690 |
15 |
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid. |
TBA |
| 4009615 |
10 |
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin. |
TBA |
| 7108907 |
11 |
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism. |
TBA |
| 21696158 |
50 |
Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening. |
Universita Degli Studi Di Modena E Reggio Emilia |
| 17532099 |
30 |
Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities. |
Università |
| 15715461 |
18 |
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine. |
Università |
| 10821704 |
22 |
Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,). |
The Institute Of Cancer Research |
| 10714507 |
1 |
Mechanism-based inactivation of thymidylate synthase by 5-(3-fluoropropyn-1-yl)-2'-deoxyuridine 5'-phosphate. |
State University Of New York |
| 8164259 |
44 |
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. |
Duquesne University |
| 7562910 |
18 |
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines. |
Duquesne University |
| 7473577 |
11 |
5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents. |
Duquesne University |
| 6796692 |
1 |
Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase. |
TBA |
| 6796687 |
6 |
Inhibition of thymidylate synthetase by 5-alkynyl-2'-deoxyuridylates. |
TBA |
| 6434741 |
2 |
Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase. |
TBA |
| 6408258 |
4 |
5-p-benzoquinonyl-2'-deoxyuridine 5'-phosphate: a possible mechanism-based inhibitor of thymidylate synthetase. |
TBA |
| 3754285 |
1 |
Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase. |
TBA |
| 3656346 |
1 |
Inactivation of thymidylate synthase at an alternate high-affinity binding site. |
University Of Kansas |
| 3599032 |
22 |
Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds. |
TBA |
| 3184124 |
28 |
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase. |
Southern Research Institute |
| 3091834 |
6 |
Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin. |
TBA |
| 3027341 |
10 |
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies. |
TBA |
| 2704030 |
16 |
Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency. |
Institute Of Cancer Research |
| 2542557 |
14 |
Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds. |
University Of South Alabama |
| 2428979 |
11 |
Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition. |
TBA |
| 2296020 |
18 |
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins. |
Sri International |
| 1995884 |
4 |
Synthesis and biological activity of 5,11-methylenetetrahydro-5- deazahomofolic acid. |
Duquesne University |
| 1732551 |
6 |
Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin. |
Southern Research Institute |
| 1433179 |
13 |
5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities. |
Duquesne University |
| 25453512 |
3 |
Design, synthesis, biological evaluation, and molecular docking of novel benzopyran and phenylpyrazole derivatives as Akt inhibitors. |
Zhejiang University |
| 22284362 |
91 |
Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. |
Boston College |
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