The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28216405 |
31 |
Design, synthesis and biological evaluation of nonsecosteroidal vitamin D |
China Pharmaceutical University |
| 27815118 |
112 |
Discovery of phenoxyindazoles and phenylthioindazoles as ROR¿ inverse agonists. |
Galderma R & D |
| 27145071 |
37 |
2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists. |
Palacky University In Olomouc |
| 27070779 |
15 |
Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer. |
University of Tennessee Health Science Center |
| 26819660 |
82 |
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor. |
Central Pharmaceutical Research Institute |
| 26774929 |
58 |
Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. |
University of Wisconsin |
| 26613420 |
15 |
Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds. |
Rikkyo University |
| 26432035 |
5 |
Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton. |
National Institute of Health Sciences |
| 26515040 |
2 |
Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity. |
Showa Pharmaceutical University |
| 26367019 |
8 |
Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1a-Hydroxyl Derivatives. |
Veterans Affairs Medical Center |
| 25637122 |
4 |
Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors. |
National Institute of Health Sciences |
| 25305688 |
41 |
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t. |
Phenex Pharmaceuticals |
| 24818857 |
3 |
Structural insights into the molecular mechanism of vitamin D receptor activation by lithocholic acid involving a new mode of ligand recognition. |
Institute of Genetics and Molecular and Cellular Biology (Igbmc) |
| 24773565 |
24 |
Combination of triple bond and adamantane ring on the vitamin D side chain produced partial agonists for vitamin D receptor. |
Rikkyo University |
| 24742174 |
11 |
A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22R-alkyl group. |
Showa Pharmaceutical University |
| 24799995 |
54 |
Development of novel Vitamin D Receptor-Coactivator Inhibitors. |
University of Wisconsin-Milwaukee |
| 24125851 |
48 |
Novel acetamidothiazole derivatives: synthesis and in vitro anticancer evaluation. |
University of Mansoura |
| 24099996 |
16 |
Novel nonsecosteroidal VDR agonists with phenyl-pyrrolyl pentane skeleton. |
China Pharmaceutical University |
| 24035340 |
3 |
Synthesis of VS-105: A novel and potent vitamin D receptor agonist with reduced hypercalcemic effects. |
Vidasym |
| 23806555 |
8 |
Development of stapled short helical peptides capable of inhibiting vitamin D receptor (VDR)-coactivator interactions. |
National Institute of Health Sciences |
| 24900728 |
7 |
Synthesis of 2?-heteroarylalkyl active vitamin d3 with therapeutic effect on enhancing bone mineral density in vivo. |
Teikyo University |
| 23414840 |
285 |
Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction. |
St. Jude Children'S Research Hospital |
| 23462715 |
25 |
Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange. |
The University of Tokyo |
| 23294828 |
17 |
Structure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators. |
The University of Tokyo |
| 23276449 |
1 |
Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists. |
Arizona State University |
| 17125259 |
84 |
Further synthetic and biological studies on vitamin D hormone antagonists based on C24-alkylation and C2alpha-functionalization of 25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones. |
Teikyo University |
| 16610783 |
7 |
Practical synthesis and evaluation of the biological activities of 1alpha,25-dihydroxyvitamin D3 antagonists, 1alpha,25-dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition hypothesis. |
University of Tokyo |
| 22989379 |
8 |
Synthesis and biological evaluation of 1a,25-dihydroxyvitamin D3 analogues with a long side chain at C12 and short C17 side chains. |
Universidad De Santiago De Compostela |
| 22957834 |
8 |
Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin D nuclear receptor. |
Institute of Genetics and Molecular and Cellular Biology (Igbmc) |
| 21354674 |
14 |
The many faces of the adamantyl group in drug design. |
University of Sydney |
| 22563729 |
80 |
Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. |
University of Wisconsin-Milwaukee |
| 22512505 |
3 |
Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligands. |
Showa Pharmaceutical University |
| 20888766 |
50 |
Novel selective anti-androgens with a diphenylpentane skeleton. |
The University of Tokyo |
| 20452225 |
49 |
Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids. |
Mcgill University |
| 17904370 |
20 |
2-Methylene 19-nor-25-dehydro-1alpha-hydroxyvitamin D3 26,23-lactones: synthesis, biological activities and molecular basis of passive antagonism. |
Tokyo Medical and Dental University |
| 18054230 |
15 |
(2S,2'R)-analogue of LG190178 is a major active isomer. |
National Institute of Health Sciences |
| 17298045 |
8 |
22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor. |
Tokyo Medical and Dental University |
| 11462969 |
7 |
New dermatological agents for the treatment of psoriasis. |
Allergan |
| 21889334 |
8 |
Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands. |
National Institute of Health Sciences |
| 20883026 |
3 |
An o-aminoanilide analogue of 1a,25-dihydroxyvitamin D(3) functions as a strong vitamin D receptor antagonist. |
Mcgill University |
| 20638278 |
145 |
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. |
Phenex Pharmaceuticals |
| 20144545 |
19 |
LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators. |
The University of Tokyo |
| 19309155 |
6 |
Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3. |
Bioxell |
| 18710208 |
5 |
Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: structural basis for vitamin D receptor antagonism and partial agonism. |
Tokyo Medical and Dental University |
| 18635349 |
13 |
Structure-activity relationship studies on vitamin D lactam derivatives as vitamin D receptor antagonist. |
Tokyo University of Agriculture and Technology |
| 17924616 |
6 |
Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1 alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation. |
The Johns Hopkins University |
| 17149880 |
4 |
Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation. |
The University of Texas |
| 17110116 |
4 |
Structure-activity relationships of 19-norvitamin D analogs having a fluoroethylidene group at the C-2 position. |
Tokyo Medical and Dental University |
| 16480267 |
3 |
Vitamin D receptor: ligand recognition and allosteric network. |
Tokyo Medical and Dental University |
| 15055995 |
3 |
Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modificatio |
Institute of Genetics and Molecular and Cellular Biology (Igbmc) |
| 32616182 |
70 |
N |
Hiroshima International University |
| 30446437 |
9 |
Structural development of non-secosteroidal vitamin D receptor (VDR) ligands without any asymmetric carbon. |
National Institute of Health Sciences |
| 31300316 |
1 |
Development of novel lithocholic acid derivatives as vitamin D receptor agonists. |
Tokyo Medical and Dental University |
| 31729873 |
43 |
Structure-Based and Property-Driven Optimization of |
Global Discovery Chemistry |
| 26562542 |
71 |
Novel nonsecosteroidal VDR ligands with phenyl-pyrrolyl pentane skeleton for cancer therapy. |
China Pharmaceutical University |
| 30193216 |
12 |
Sulfonyl-containing phenyl-pyrrolyl pentane analogues: Novel non-secosteroidal vitamin D receptor modulators with favorable physicochemical properties, pharmacokinetic properties and anti-tumor activity. |
China Pharmaceutical University |
| 30144697 |
66 |
Synthesis and evaluation of 4-cycloheptylphenols as selective Estrogen receptor-? agonists (SERBAs). |
Marquette University |
| 29571573 |
34 |
Sulfoximines as potent ROR? inverse agonists. |
Nestle Skin Health |
| 29733645 |
12 |
Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists. |
University of Santiago De Compostela |
| 29989817 |
13 |
25 S-Adamantyl-23-yne-26,27-dinor-1?,25-dihydroxyvitamin D |
Universidad De Santiago De Compostela |
| 29936834 |
5 |
Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic Ligands. |
Showa Pharmaceutical University |
| 29518319 |
36 |
Further Developments of the Phenyl-Pyrrolyl Pentane Series of Nonsteroidal Vitamin D Receptor Modulators as Anticancer Agents. |
China Pharmaceutical University |
| 28610979 |
3 |
Synthesis and biological evaluation of steroidal derivatives bearing a small ring as vitamin D receptor agonists. |
Kyoto University |
| 29045135 |
12 |
Structural Basis of Inhibition of ER?-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides. |
Shenzhen Graduate School of Peking University |
| 28954197 |
11 |
Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action. |
Showa Pharmaceutical University |
| 22107736 |
8 |
Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors. |
National Institutes of Health |
| 15801830 |
127 |
Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4. |
Pfizer |
Search and Browse
