55 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
24946214	24	Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors.	Universit£
24561716	18	Identification of a new series of amides as non-covalent proteasome inhibitors.	Universit£
24102612	105	Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity.	University of Bari &Quot;Aldo Moro&Quot
22770607	54	Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.	Virginia Commonwealth University
14640539	112	Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).	Pharmaceutical Research Institute
14521410	36	Identification and prediction of promiscuous aggregating inhibitors among known drugs.	Northwestern University
11931626	124	A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.	Northwestern University
12190311	37	Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).	Gsk
11312927	64	Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase.	Welfide
10579821	51	Design and synthesis of thrombin inhibitors: analogues of MD-805 with reduced stereogenicity and improved potency.	Novartis Horsham Research Centre
2296008	13	Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases.	Merrell Dow Research Institute
	24	L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitor	TBA
22377673	4	Proteasome inhibitors for cancer therapy.	Cephalon
20945905	4	Design, synthesis, crystal structures, and antimicrobial activity of sulfonamide boronic acids asß-lactamase inhibitors.	University of California San Francisco
20020755	2	Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis.	Smithsonian Marine Station At Ft. Pierce
	46	1,3-Oxazino[4,5-b]indole-2,4-(1H,9H)-diones and 5,6-dimethylpyrrolo-[2,3-d]-1,3-oxazin-2,4-(1H,7H)-diones as serine protease inhi...	TBA
	9	Diphenylborinic acid is a strong inhibitor of serine proteases	TBA
	2	Stereochemical approach for enzyme inhibitor design	TBA
	4	Engineering of cyclic peptides with novel inhibiting properties to differentiate two serine proteases, chymotrypsin and subtilisin Carlsberg	TBA
	2	Boric acid effect ont he hydrolysis of 4-nitrophenyl 2,3-dihydroxybenzoate: mimic of borate inhibition of serine proteases	TBA
	7	Janus compounds: dual inhibitors of proteinases	TBA
	12	MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities.	TBA
	5	Borinic acid inhibitors as probes of the factors involved in binding at the active sites of subtilisin carlsberg and α-chymotrypsin	TBA
14684338	44	P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl alpha-ketoamide based HCV protease inhibitors.	Eli Lilly
12593666	30	Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor.	Senju Pharmaceutical
11549442	6	Alpha-ketoester-based photobiological switches: synthesis, peptide chain extension and assay against alpha-chymotrypsin.	University of Canterbury
11078188	20	1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma.	Shionogi
10866385	13	Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha1-antitrypsin.	The Oxford Centre For Molecular Sciences
10698435	150	Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors.	Kyoto Pharmaceutical University
9925737	57	N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.	Nippon Steel
9871686	23	Design and synthesis of monocyclic beta-lactams as mechanism-based inhibitors of human cytomegalovirus protease.	Glaxo Wellcome Research and Development
9871511	54	Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites.	Green Cross Research Laboratories
9804697	61	Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.	Northwestern University Medical School
9767628	31	Syntheses of trans-5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-oxo-hexahydro-furo[3,2-b]pyrroles (pyrrolidine trans-lactams and trans-lactones): new pharmacophores for elastase inhibition.	Glaxowellcome Medicines Research Centre
9703466	35	Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position.	Merck Research Laboratories
9667976	58	beta-Lactam derivatives as inhibitors of human cytomegalovirus protease.	Boehringer Ingelheim (Canada)
9406601	109	Peptidomimetic inhibitors of the human cytomegalovirus protease.	Boehringer Ingelheim
9216834	153	Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase.	Suntory
31223449	18	DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors.	Kyushu University
8691456	7	Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of alpha-chymotrypsin: significance of the"aromatic" nature of the novel ester-type coumarin for strong inhibitory activity.	Université
7837244	33	Non-peptidic inhibitors of human leukocyte elastase. 4. Design, synthesis, and in vitro and in vivo activity of a series of beta-carbolinone-containing trifluoromethyl ketones.	Zeneca Pharmaceuticals
7739010	118	Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin.	Thrombosis Research Institute
7629790	32	New orally active serine protease inhibitors.	Minase Research Institute
7562931	41	Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles.	Zeneca Pharmaceuticals
3941405	15	Carboxyl-modified amino acids and peptides as protease inhibitors.	TBA
29039662	62	Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds.	Csir-National Chemical Laboratory
30222343	4	Dinghupeptins A-D, Chymotrypsin Inhibitory Cyclodepsipeptides Produced by a Soil-Derived Streptomyces.	Chinese Academy of Sciences
29463448	1	Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.	Heinrich-Heine University Duesseldorf
29936356	27	Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1.	The University of Queensland
2391691	55	Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters.	Merck Sharp and Dohme Research Laboratories
2187995	12	O'-(epoxyalkyl)tyrosines and (epoxyalkyl)phenylalanine as irreversible inactivators of serine proteases: synthesis and inhibition mechanism.	State University
1447734	29	Effect of conformational mobility and hydrogen-bonding interactions on the selectivity of some guanidinoaryl-substituted mechanism-based inhibitors of trypsin-like serine proteases.	University of Illinois
27775715	113	Design and characterization of bivalent BET inhibitors.	Dana-Farber Cancer Institute
10869410	62	S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626.	Centre De Recherches De Croissy