33 articles for thisTarget

---

The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
25937878	9	The chemistry and pharmacology of privileged pyrroloquinazolines.	Oregon Health & Science University
8201595	12	Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.	Eisai
1995880	8	Synthesis and biological activity of methotrexate analogues with two acid groups and a hydrophobic aromatic ring in the side chain.	Harvard Medical School
2898531	20	Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.	Harvard Medical School
3385730	13	Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.	Harvard Medical School
3351853	5	Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.	Institute
3112397	5	Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate.	TBA
3462394	12	Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.	TBA
2423690	15	Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.	TBA
2871191	11	Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.	TBA
7108907	11	10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.	TBA
7143361	6	Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.	TBA
12825924	8	Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate.	University Of Minnesota
8863812	8	Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors.	State University Of New York
8340923	7	Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.	Sri International
8277497	17	Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.	Southern Research Institute
7057425	13	Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism.	TBA
6737432	4	Methotrexate analogues. 23. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates.	TBA
4045922	4	Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent.	TBA
4020824	11	Syntheses and evaluation as antifolates of MTX analogues derived from 2, omega-diaminoalkanoic acids.	TBA
3968685	7	Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.	TBA
3754284	13	Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications.	TBA
3712374	25	Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.	TBA
3385729	7	Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition.	Harvard Medical School
3373490	7	Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s).	Cornell University
3184124	28	Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.	Southern Research Institute
2428979	11	Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition.	TBA
2299633	6	Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid.	Sri International
2296020	18	Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.	Sri International
1732551	6	Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.	Southern Research Institute
1732549	4	Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.	Sri International
1501226	2	Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).	Southern Research Institute
11082453	77	ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse.	Abbott Laboratories