The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28169167 |
137 |
Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
27639361 |
88 |
Synthesis and biological evaluation of novel hybrids of highly potent and selectivea4ß2-Nicotinic acetylcholine receptor (nAChR) partial agonists. |
University of Illinois At Chicago |
26706350 |
48 |
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for thea3ß4 nicotinic acetylcholine receptor subtype. |
Universit£ |
26383127 |
13 |
Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities fora4ß2 neuronal nicotinic acetylcholine receptors. |
University of Sassari |
26301559 |
10 |
Exploration of the molecular architecture of the orthosteric binding site in thea4ß2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane. |
University of Copenhagen |
26164842 |
30 |
Bifunctional compounds targeting both D2 and non-a7 nACh receptors: design, synthesis and pharmacological characterization. |
Universit£ |
26225816 |
25 |
Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed asa4ß2-Nicotinic Acetylcholine Receptor Agonists. |
Universit£ |
26142318 |
36 |
The twin drug approach for novel nicotinic acetylcholine receptor ligands. |
University of Hawaii At Hilo |
24814197 |
63 |
Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines asa7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders. |
Critical Therapeutics |
24187998 |
96 |
Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists. |
University of Copenhagen |
24050653 |
59 |
Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors. |
The Johns Hopkins University School of Medicine |
24365158 |
9 |
Synthesis and activity of substituted heteroaromatics as positive allosteric modulators fora4ß2a5 nicotinic acetylcholine receptors. |
The Scripps Research Institute |
24200193 |
32 |
Characterization of a novela-conotoxin TxID from Conus textile that potently blocks rata3ß4 nicotinic acetylcholine receptors. |
Hainan University |
24156938 |
12 |
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents. |
University of Bonn |
24047231 |
52 |
Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands. |
Georgetown University |
24128660 |
6 |
Design, synthesis and binding affinity of acetylcholine carbamoyl analogues. |
Universit£ |
24035337 |
10 |
2-Amino-6-chloro-3,4-dihydroquinazoline: A novel 5-HT3 receptor antagonist with antidepressant character. |
Virginia Commonwealth University |
23886687 |
9 |
QM-polarized ligand docking accurately predicts the trend in binding affinity of a series of arylmethylene quinuclidine-like derivatives at thea4ß2 anda3ß4 nicotinic acetylcholine receptors (nAChRs). |
Targacept |
23757208 |
29 |
Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies. |
The Ohio State University |
23734673 |
10 |
Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selectivea4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II. |
University of Illinois At Chicago |
23692872 |
98 |
Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor. |
Targacept |
23602445 |
23 |
An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'. |
Ucl School of Pharmacy |
23561269 |
53 |
Neonicotinic analogues: selective antagonists fora4ß2 nicotinic acetylcholine receptors. |
University of Chile |
23507153 |
4 |
Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging ofa7 nicotinic acetylcholine receptors. |
Helmholtz-Zentrum Dresden-Rossendorf |
23414838 |
33 |
Discovery of a novel series of quinolonea7 nicotinic acetylcholine receptor agonists. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
23461628 |
9 |
(+)-Laburnamine, a natural selective ligand and partial agonist for the?4?2 nicotinic receptor subtype. |
Universit£ |
23540678 |
26 |
Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selectivea4ß2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats. |
Georgetown University Medical Center |
23121096 |
86 |
Ion channels as therapeutic targets: a drug discovery perspective. |
Pfizer |
23256554 |
16 |
Synthesis, pharmacology, and biostructural characterization of novela4ß2 nicotinic acetylcholine receptor agonists. |
University of Copenhagen |
22285942 |
79 |
3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of humana4ß2 neuronal nicotinic acetylcholine receptors. |
The Ohio State University |
22243960 |
88 |
Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein. |
Vu University Amsterdam |
22177081 |
2 |
Discovery of novela7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs. |
Targacept |
22060139 |
21 |
Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors. |
The Ohio State University |
21905680 |
26 |
Deconstruction of thea4ß2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine. |
Virginia Commonwealth University |
20822184 |
27 |
Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) asa4ß2-nicotinic acetylcholine receptor-selective partial agonists. |
University of Illinois At Chicago |
17889526 |
2 |
Unique spirocyclopiperazinium salt III: further investigation of monospirocyclopiperazinium (MSPZ) salts as potential analgesics. |
Peking University |
17994682 |
11 |
Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine. |
Research Triangle Institute |
17929796 |
55 |
Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists. |
Neuroscience Research |
17585748 |
31 |
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors. |
Abbott Laboratories |
17181167 |
50 |
Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists. |
Abbott Laboratories |
16722642 |
1 |
Synthesis and pharmacological characterization of nicotinic acetylcholine receptor properties of (+)- and (-)-pyrido-[3,4-b]homotropanes. |
Research Triangle Institute |
16412637 |
8 |
Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. |
Peking University |
16289815 |
1 |
A novel nicotinic acetylcholine receptor antagonist radioligand for PET studies. |
Brookhaven National Laboratory |
15686946 |
36 |
Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors. |
National Institute of Diabetes and Digestive and Kidney Diseases |
15050612 |
8 |
alpha4beta2 nACh receptor pharmacophore models. |
Virginia Commonwealth University |
14698195 |
20 |
3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors. |
Virginia Commonwealth University |
23641311 |
38 |
From a4ß2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design. |
TBA |
23126648 |
213 |
Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. |
Targacept |
23092294 |
75 |
Discovery of highly potent and selectivea4ß2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. |
University of Illinois At Chicago |
23025891 |
169 |
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands. |
Targacept |
22928944 |
12 |
Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands toa4ß2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands. |
University of Illinois At Chicago |
22793665 |
190 |
Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selectivea4ß2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. |
Targacept |
21919481 |
114 |
Discovery and development ofa7 nicotinic acetylcholine receptor modulators. |
Targacept |
22591063 |
12 |
Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711). |
University of Berne |
22749278 |
16 |
Diazaspirocyclic compounds as selective ligands for thea4ß2 nicotinic acetylcholine receptor. |
Targacept |
22171543 |
22 |
Chemistry and behavioral studies identify chiral cyclopropanes as selectivea4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. |
University of Illinois At Chicago |
24936233 |
8 |
Discovery of Novel a4ß2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening. |
TBA |
22503453 |
59 |
The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement. |
Glaxosmithkline |
22503248 |
61 |
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition. |
Glaxosmithkline |
21058665 |
52 |
Nicotinic Acetylcholine Receptor Efficacy and Pharmacological Properties of 3-(Substituted phenyl)-2ß-substituted Tropanes. |
Research Triangle Institute |
20684563 |
176 |
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. |
H. Lundbeck |
20663668 |
43 |
A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists. |
Pfizer |
19954975 |
27 |
Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor. |
Abbott Laboratories |
16934977 |
16 |
Epibatidine isomers and analogues: structure-activity relationships. |
University of Leicester |
16765047 |
23 |
Aryloxyethylamines: binding at alpha7 nicotinic acetylcholine receptors. |
Virginia Commonwealth University |
16171993 |
45 |
3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation. |
Pfizer |
16033252 |
84 |
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. |
The Danish University of Pharmaceutical Sciences |
15808471 |
144 |
2-(Arylmethyl)-3-substituted quinuclidines as selective alpha 7 nicotinic receptor ligands. |
Targacept |
15908213 |
35 |
In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine. |
Pfizer |
9484491 |
23 |
Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
Abbott Laboratories |
9435889 |
70 |
Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
Abbott Laboratories |
8765504 |
34 |
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. |
Sibia Neurosciences |
15050614 |
10 |
Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
University of Florida |
15203136 |
39 |
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents. |
Virginia Commonwealth University |
11212100 |
27 |
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist. |
Astrazeneca |
22281189 |
63 |
SAR ofa7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore. |
Abbott Laboratories |
22222032 |
3 |
Synthesis and binding affinity ata4ß2 anda7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system. |
Universit£ |
21905669 |
9 |
Discovery of isoxazole analogues of sazetidine-A as selectivea4ß2-nicotinic acetylcholine receptor partial agonists for the treatment of depression. |
University of Illinois At Chicago |
21920761 |
52 |
Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors. |
Vu University Amsterdam |
21319801 |
54 |
Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine. |
Research Triangle Institute |
21397497 |
18 |
Discovery of non-peptide, small molecule antagonists ofa9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain. |
University of Kentucky |
20509659 |
182 |
Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. |
Barrow Neurological Institute |
20465311 |
36 |
Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914). |
Siena Biotech |
20158204 |
136 |
Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. |
Research Triangle Institute |
| 11 |
Novel 2-(2′-furo[3,2-b]pyridinyl) pyrrolidines: potent neuronal nicotinic acetylcholine receptor ligands |
TBA |
17827002 |
6 |
Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors. |
University of Toyama |
17604168 |
3 |
Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator. |
Virginia Commonwealth University |
17391965 |
28 |
Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. |
University of Chile |
14684341 |
15 |
Synthesis and nicotinic receptor activity of a hydroxylated tropane. |
University of Wollongong |
12565964 |
4 |
5-Azidoepibatidine: an exceptionally potent photoaffinity ligand for neuronal alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors. |
University of California |
12061885 |
22 |
Structural features of azidopyridinyl neonicotinoid probes conferring high affinity and selectivity for mammalian alpha4beta2 and Drosophila nicotinic receptors. |
University of California |
32026697 |
111 |
Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine ?4?2 Receptor Antagonist for the Treatment of Depression. |
Suven Life Sciences |
27774124 |
76 |
Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds. |
Mahidol University |
31434041 |
12 |
Discovery of fused heterocyclic carboxamide derivatives as novel ?7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. |
Peking University |
10447950 |
15 |
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions. |
Targacept |
10377231 |
2 |
Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors. |
Cea |
9873508 |
3 |
Conformationally restricted analogues of nicotine and anabasine. |
Sibia Neurosciences |
31185168 |
144 |
Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor. |
Rti International |
31299587 |
56 |
Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors. |
Universit£ |
31244109 |
36 |
Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency. |
University of Nottingham |
9871663 |
49 |
Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist. |
Abbott Laboratories |
31271958 |
53 |
Bis(het)aryl-1,2,3-triazole quinuclidines as ?7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [ |
Universit£ |
31401465 |
52 |
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. |
Julius Maximilian University of W£Rzburg |
31276409 |
8 |
Alkaloids Purified from |
American University of Health Sciences |
26580980 |
38 |
Design of ?7 nicotinic acetylcholine receptor ligands using the (het)Aryl-1,2,3-triazole core: Synthesis, in vitro evaluation and SAR studies. |
Universite Orleans |
25147147 |
101 |
Identification and pharmacological characterization of 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides as novel ligands for the ?4?2 and ?6/?3?2?3 nicotinic acetylcholine receptors (nAChRs). |
Targacept |
30403486 |
35 |
Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an ?7-nAChR, ?9-nAChR Antagonist and of a Pro-Oxidant Mitocan. |
Universit£ |
29671588 |
35 |
Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine. |
Indiana State University |
29634269 |
11 |
Drimane Sesquiterpenoids Noncompetitively Inhibit Human ?4?2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human ?3?4 and ?7 Subtypes. |
California Northstate University College of Medicine |
28606760 |
57 |
Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors. |
Amgen |
29751234 |
94 |
Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for ? |
Istituto Di Chimica Biomolecolare |
29384668 |
249 |
Dual Nicotinic Acetylcholine Receptor ?4?2 Antagonists/?7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts. |
University of Copenhagen |
27810599 |
14 |
From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at?4?2 nicotinic acetylcholine receptor. |
Universit£ |
29094937 |
194 |
Structure-Based Design and Discovery of New M |
University of California |
28885019 |
6 |
Sulfonium as a Surrogate for Ammonium: A New?7 Nicotinic Acetylcholine Receptor Partial Agonist with Desensitizing Activity. |
University of Florida |