The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28406621 |
65 |
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties. |
Dart Neuroscience |
28165743 |
37 |
Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. |
Dart Neuroscience |
27597413 |
58 |
Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings. |
Southern Medical University |
27606546 |
218 |
Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease. |
University of Navarra |
26526739 |
35 |
Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships. |
Southern Medical University |
25801159 |
36 |
Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5. |
Csir-Indian Institute of Integrative Medicine |
23137303 |
38 |
Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. |
Chinese Academy of Sciences |
18778098 |
12 |
Potent inhibition of human phosphodiesterase-5 by icariin derivatives. |
University of Milan |
15887951 |
29 |
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. |
Monash University (Parkville Campus) |
16913726 |
33 |
Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction. |
Università |
15006407 |
15 |
Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
12668004 |
76 |
Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors. |
Pfizer |
32171616 |
32 |
Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer's disease. |
Changzhou University |
32603117 |
32 |
Discovery of Novel Selective and Orally Bioavailable Phosphodiesterase-1 Inhibitors for the Efficient Treatment of Idiopathic Pulmonary Fibrosis. |
Sun Yat-Sen University |
26908025 |
164 |
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design. |
Vrije Universiteit Amsterdam |
31099559 |
36 |
Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. |
Shanghai Institute of Materia Medica |
31021628 |
50 |
Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. |
Chinese Academy of Sciences |
30888810 |
48 |
Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors. |
Sun Yat-Sen University |
31103902 |
41 |
Multi-target design strategies for the improved treatment of Alzheimer's disease. |
China Pharmaceutical University |
31235264 |
13 |
Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. |
Mitsubishi Tanabe Pharma |
30986068 |
112 |
Structure Overhaul Affords a Potent Purine PI3K? Inhibitor with Improved Tolerability. |
TBA |
31610942 |
65 |
Discovery of novel inhibitors of phosphodiesterase 4 with 1-phenyl-3,4-dihydroisoquinoline scaffold: Structure-based drug design and fragment identification. |
South China Agricultural University |
25062128 |
16 |
Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). |
Amgen |
23867165 |
21 |
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. |
Chinese Academy of Sciences |
30245400 |
167 |
Discovery of furyl/thienyl ?-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect. |
Shandong University |
30148362 |
36 |
Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension. |
Sun Yat-Sen University |
29549837 |
151 |
Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease. |
University of Navarra |
29505934 |
31 |
Design and synthesis of furyl/thineyl pyrroloquinolones based on natural alkaloid perlolyrine, lead to the discovery of potent and selective PDE5 inhibitors. |
Shandong University |
29545101 |
55 |
Structure-based design and structure-activity relationships of 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors. |
South China Agricultural University |
28985058 |
20 |
Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease. |
Columbia University |