Found 55 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM14774
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
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| PDB
Article
PubMed
| n/a | n/a | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM14774
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
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| DrugBank
PDB
Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455386
(CHEMBL4213076)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C23H24F3NO4/c1-29-20-12-16-10-11-27(14-17(16)13-21(20)30-18-4-2-3-5-18)22(28)15-6-8-19(9-7-15)31-23(24,25)26/h6-9,12-13,18H,2-5,10-11,14H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
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| PDB
Article
PubMed
| n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
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| PDB
Article
PubMed
| n/a | n/a | 1.43E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455391
(CHEMBL4215240)Show SMILES CCOC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C26H28F3NO6/c1-3-34-25(32)21-12-17-13-22(33-2)23(35-19-6-4-5-7-19)14-18(17)15-30(21)24(31)16-8-10-20(11-9-16)36-26(27,28)29/h8-11,13-14,19,21H,3-7,12,15H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455394
(CHEMBL4208161)Show SMILES COc1ccc(cc1)C(=O)N1CCc2cc(OC)c(OC3CCCC3)cc2C1 Show InChI InChI=1S/C23H27NO4/c1-26-19-9-7-16(8-10-19)23(25)24-12-11-17-13-21(27-2)22(14-18(17)15-24)28-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455396
(CHEMBL4211564)Show SMILES COc1ccc(cc1OC)C(=O)N1CCc2cc(OC)c(OC3CCCC3)cc2C1 Show InChI InChI=1S/C24H29NO5/c1-27-20-9-8-17(13-21(20)28-2)24(26)25-11-10-16-12-22(29-3)23(14-18(16)15-25)30-19-6-4-5-7-19/h8-9,12-14,19H,4-7,10-11,15H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455389
(CHEMBL4216542)Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2cc(OC)c(OC3CCCC3)cc2C1 Show InChI InChI=1S/C22H27NO5S/c1-26-18-7-9-20(10-8-18)29(24,25)23-12-11-16-13-21(27-2)22(14-17(16)15-23)28-19-5-3-4-6-19/h7-10,13-14,19H,3-6,11-12,15H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455397
(CHEMBL4217492)Show InChI InChI=1S/C22H25NO4/c1-26-20-12-16-10-11-23(22(25)15-6-8-18(24)9-7-15)14-17(16)13-21(20)27-19-4-2-3-5-19/h6-9,12-13,19,24H,2-5,10-11,14H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455388
(CHEMBL4205250)Show SMILES COc1ccc(cc1O)C(=O)N1CCc2cc(OC)c(OC3CCCC3)cc2C1 Show InChI InChI=1S/C23H27NO5/c1-27-20-8-7-16(11-19(20)25)23(26)24-10-9-15-12-21(28-2)22(13-17(15)14-24)29-18-5-3-4-6-18/h7-8,11-13,18,25H,3-6,9-10,14H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50455386
(CHEMBL4213076)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C23H24F3NO4/c1-29-20-12-16-10-11-27(14-17(16)13-21(20)30-18-4-2-3-5-18)22(28)15-6-8-19(9-7-15)31-23(24,25)26/h6-9,12-13,18H,2-5,10-11,14H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455382
(CHEMBL4210402)Show SMILES COc1cc2CC(N(Cc2cc1OC1CCCC1)C(=O)c1ccc(OC(F)(F)F)cc1)C(=O)N(C)C Show InChI InChI=1S/C26H29F3N2O5/c1-30(2)25(33)21-12-17-13-22(34-3)23(35-19-6-4-5-7-19)14-18(17)15-31(21)24(32)16-8-10-20(11-9-16)36-26(27,28)29/h8-11,13-14,19,21H,4-7,12,15H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455401
(CHEMBL4210828)Show SMILES COc1cc2CC(N(Cc2cc1OC1CCCC1)C(=O)c1ccc(OC(F)(F)F)cc1)C(O)=O Show InChI InChI=1S/C24H24F3NO6/c1-32-20-11-15-10-19(23(30)31)28(13-16(15)12-21(20)33-17-4-2-3-5-17)22(29)14-6-8-18(9-7-14)34-24(25,26)27/h6-9,11-12,17,19H,2-5,10,13H2,1H3,(H,30,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455390
(CHEMBL4206447)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H24ClNO4S/c1-26-20-12-15-10-11-23(28(24,25)19-8-6-17(22)7-9-19)14-16(15)13-21(20)27-18-4-2-3-5-18/h6-9,12-13,18H,2-5,10-11,14H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455400
(CHEMBL4212232)Show SMILES CCN(CC)C(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C28H33F3N2O5/c1-4-32(5-2)27(35)23-14-19-15-24(36-3)25(37-21-8-6-7-9-21)16-20(19)17-33(23)26(34)18-10-12-22(13-11-18)38-28(29,30)31/h10-13,15-16,21,23H,4-9,14,17H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50455394
(CHEMBL4208161)Show SMILES COc1ccc(cc1)C(=O)N1CCc2cc(OC)c(OC3CCCC3)cc2C1 Show InChI InChI=1S/C23H27NO4/c1-26-19-9-7-16(8-10-19)23(25)24-12-11-17-13-21(27-2)22(14-18(17)15-24)28-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.33E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50455397
(CHEMBL4217492)Show InChI InChI=1S/C22H25NO4/c1-26-20-12-16-10-11-23(22(25)15-6-8-18(24)9-7-15)14-17(16)13-21(20)27-19-4-2-3-5-19/h6-9,12-13,19,24H,2-5,10-11,14H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455399
(CHEMBL4205521)Show SMILES CNC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H27F3N2O5/c1-29-23(31)20-11-16-12-21(33-2)22(34-18-5-3-4-6-18)13-17(16)14-30(20)24(32)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3,(H,29,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.64E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50455396
(CHEMBL4211564)Show SMILES COc1ccc(cc1OC)C(=O)N1CCc2cc(OC)c(OC3CCCC3)cc2C1 Show InChI InChI=1S/C24H29NO5/c1-27-20-9-8-17(13-21(20)28-2)24(26)25-11-10-16-12-22(29-3)23(14-18(16)15-25)30-19-6-4-5-7-19/h8-9,12-14,19H,4-7,10-11,15H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455395
(CHEMBL4204765)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H24ClNO3/c1-26-20-12-16-10-11-24(22(25)15-6-8-18(23)9-7-15)14-17(16)13-21(20)27-19-4-2-3-5-19/h6-9,12-13,19H,2-5,10-11,14H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50455388
(CHEMBL4205250)Show SMILES COc1ccc(cc1O)C(=O)N1CCc2cc(OC)c(OC3CCCC3)cc2C1 Show InChI InChI=1S/C23H27NO5/c1-27-20-8-7-16(11-19(20)25)23(26)24-10-9-15-12-21(28-2)22(13-17(15)14-24)29-18-5-3-4-6-18/h7-8,11-13,18,25H,3-6,9-10,14H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455387
(CHEMBL4209631)Show SMILES COc1cccc(c1)C(=O)N1CCc2cc(OC)c(OC3CCCC3)cc2C1 Show InChI InChI=1S/C23H27NO4/c1-26-20-9-5-6-17(12-20)23(25)24-11-10-16-13-21(27-2)22(14-18(16)15-24)28-19-7-3-4-8-19/h5-6,9,12-14,19H,3-4,7-8,10-11,15H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455385
(CHEMBL4216965)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)C(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H24ClNO3/c1-26-20-12-15-9-10-24(22(25)16-5-4-6-18(23)11-16)14-17(15)13-21(20)27-19-7-2-3-8-19/h4-6,11-13,19H,2-3,7-10,14H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50455391
(CHEMBL4215240)Show SMILES CCOC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C26H28F3NO6/c1-3-34-25(32)21-12-17-13-22(33-2)23(35-19-6-4-5-7-19)14-18(17)15-30(21)24(31)16-8-10-20(11-9-16)36-26(27,28)29/h8-11,13-14,19,21H,3-7,12,15H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50455389
(CHEMBL4216542)Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2cc(OC)c(OC3CCCC3)cc2C1 Show InChI InChI=1S/C22H27NO5S/c1-26-18-7-9-20(10-8-18)29(24,25)23-12-11-16-13-21(27-2)22(14-17(16)15-23)28-19-5-3-4-6-19/h7-10,13-14,19H,3-6,11-12,15H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.36E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455398
(CHEMBL4203562)Show SMILES CCCCCOC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C29H34F3NO6/c1-3-4-7-14-37-28(35)24-15-20-16-25(36-2)26(38-22-8-5-6-9-22)17-21(20)18-33(24)27(34)19-10-12-23(13-11-19)39-29(30,31)32/h10-13,16-17,22,24H,3-9,14-15,18H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455393
(CHEMBL4207920)Show SMILES COc1cc2CC(N(Cc2cc1OC1CCCC1)C(=O)c1ccc(OC(F)(F)F)cc1)C(=O)OCc1ccccc1 Show InChI InChI=1S/C31H30F3NO6/c1-38-27-16-22-15-26(30(37)39-19-20-7-3-2-4-8-20)35(18-23(22)17-28(27)40-24-9-5-6-10-24)29(36)21-11-13-25(14-12-21)41-31(32,33)34/h2-4,7-8,11-14,16-17,24,26H,5-6,9-10,15,18-19H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50455392
(CHEMBL4203037)Show SMILES COc1cc2CC(N(Cc2cc1OC1CCCC1)C(=O)c1ccc(OC(F)(F)F)cc1)C(=O)OC1CCCC1 Show InChI InChI=1S/C29H32F3NO6/c1-36-25-15-19-14-24(28(35)38-22-8-4-5-9-22)33(17-20(19)16-26(25)37-21-6-2-3-7-21)27(34)18-10-12-23(13-11-18)39-29(30,31)32/h10-13,15-16,21-22,24H,2-9,14,17H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4B using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50455395
(CHEMBL4204765)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H24ClNO3/c1-26-20-12-16-10-11-24(22(25)15-6-8-18(23)9-7-15)14-17(16)13-21(20)27-19-4-2-3-5-19/h6-9,12-13,19H,2-5,10-11,14H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE2A |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE9A2 |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE8A1 |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A2 |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE10A2 |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE6C |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE1A |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5A |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE7A |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5A |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE3B |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE11A |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE1A |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE2A |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM50455383
(CHEMBL4215772)Show SMILES COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE8A1 |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE11A |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE9A2 |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE3B |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
(Homo sapiens (Human)) | BDBM50455384
(CHEMBL4206423)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE6C |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50455390
(CHEMBL4206447)Show SMILES COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H24ClNO4S/c1-26-20-12-15-10-11-23(28(24,25)19-8-6-17(22)7-9-19)14-16(15)13-21(20)27-18-4-2-3-5-18/h6-9,12-13,18H,2-5,10-11,14H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.34E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
South China Agricultural University
Curated by ChEMBL
| Assay Description
Inhibition of human U937 cells-derived PDE4D using [3H]-cAMP as substrate after 30 mins |
Bioorg Med Chem Lett 28: 1188-1193 (2018)
Article DOI: 10.1016/j.bmcl.2018.02.056
BindingDB Entry DOI: 10.7270/Q2W66PBS |
More data for this
Ligand-Target Pair | |
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