The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
25086681 |
57 |
Structure-based optimization of non-peptidic Cathepsin D inhibitors. |
Merck |
8120867 |
70 |
Non-peptide renin inhibitors containing 2-(((3-phenylpropyl)phosphoryl)oxy)alkanoic acid moieties as P2-P3 replacements. |
E. Merck Darmstadt |
8474103 |
123 |
Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung. |
Abbott Laboratories |
1635057 |
48 |
Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors. |
Parke-Davis Pharmaceutical Research Division Of Warner-Lambert |
1732531 |
88 |
Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors. |
Warner-Lambert |
2066966 |
32 |
Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate. |
Warner-Lambert |
1956045 |
88 |
Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites. |
E. Merck Darmstadt |
2120440 |
23 |
Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction. |
Kissei Pharmaceutical |
3783611 |
55 |
Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin. |
TBA |
3531518 |
17 |
Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo. |
TBA |
3531517 |
17 |
Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues. |
TBA |
3906126 |
10 |
Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors. |
TBA |
19615901 |
52 |
The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin. |
Nagasaki International University |
| 23 |
Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosets |
TBA |
3309313 |
48 |
Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond. |
Abbott Laboratories |
3276890 |
28 |
Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen. |
Abbott Laboratories |
3137345 |
19 |
Synthesis and biological activity of some transition-state inhibitors of human renin. |
Ciba-Geigy |
3126296 |
43 |
Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases. |
University Of Wisconsin |
1901910 |
87 |
New inhibitors of human renin that contain novel replacements at the P2 site. |
Warner-Lambert |
1552498 |
55 |
Renin inhibitors containing alpha-heteroatom amino acids as P2 residues. |
Warner-Lambert |
1404233 |
68 |
Renin inhibitors containing new P1-P1' dipeptide mimetics with heterocycles in P1'. |
E. Merck Darmstadt |