The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28169167 |
137 |
Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 27818109 |
30 |
Novel 5-substituted 3-hydroxyphenyl and 3-nitrophenyl ethers of S-prolinol asa4ß2-nicotinic acetylcholine receptor ligands. |
Universit£ |
| 26706350 |
48 |
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for thea3ß4 nicotinic acetylcholine receptor subtype. |
Universit£ |
| 26142318 |
36 |
The twin drug approach for novel nicotinic acetylcholine receptor ligands. |
University of Hawaii At Hilo |
| 24050653 |
59 |
Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors. |
The Johns Hopkins University School of Medicine |
| 24649848 |
47 |
Discovery of a potent and selectivea3ß4 nicotinic acetylcholine receptor antagonist from ana-conotoxin synthetic combinatorial library. |
Torrey Pines Institute For Molecular Studies |
| 24274400 |
28 |
Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies. |
Torrey Pines Institute For Molecular Studies |
| 24200193 |
32 |
Characterization of a novela-conotoxin TxID from Conus textile that potently blocks rata3ß4 nicotinic acetylcholine receptors. |
Hainan University |
| 24156938 |
12 |
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents. |
University of Bonn |
| 22468936 |
49 |
Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789). |
Siena Biotech |
| 20591663 |
23 |
Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods. |
Glaxosmithkline |
| 19026537 |
90 |
3D-QSAR and QSSR studies of 3,8-diazabicyclo[4.2.0]octane derivatives as neuronal nicotinic acetylcholine receptors by comparative molecular field analysis (CoMFA). |
Burnham Institute For Medical Research |
| 23641311 |
38 |
From a4ß2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design. |
TBA |
| 23083093 |
25 |
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward ana7 nicotinic acetylcholine receptor agonist preclinical candidate. |
Siena Biotech |
| 22749278 |
16 |
Diazaspirocyclic compounds as selective ligands for thea4ß2 nicotinic acetylcholine receptor. |
Targacept |
| 24936233 |
8 |
Discovery of Novel a4ß2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening. |
TBA |
| 19954975 |
27 |
Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor. |
Abbott Laboratories |
| 19576766 |
86 |
Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
Pfizer |
| 18989912 |
95 |
Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist. |
University of Copenhagen |
| 16033252 |
84 |
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. |
The Danish University of Pharmaceutical Sciences |
| 12801235 |
5 |
Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. |
University of Vermont |
| 9484491 |
23 |
Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. |
Abbott Laboratories |
| 9435889 |
70 |
Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
Abbott Laboratories |
| 8765504 |
34 |
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. |
Sibia Neurosciences |
| 15050614 |
10 |
Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
University of Florida |
| 15203153 |
23 |
Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the alpha3beta4* nicotinic acetylcholine receptors through modifications to the ester. |
Ohio University |
| 11212100 |
27 |
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist. |
Astrazeneca |
| 22281189 |
63 |
SAR ofa7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore. |
Abbott Laboratories |
| 21319801 |
54 |
Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine. |
Research Triangle Institute |
| 21397497 |
18 |
Discovery of non-peptide, small molecule antagonists ofa9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain. |
University of Kentucky |
| 20681583 |
7 |
Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities. |
Hokkaido University |
| 20509659 |
182 |
Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. |
Barrow Neurological Institute |
| | 16 |
Identification of novel (isoxazole)methylene-1-azabicyclic compounds with high affinity for the central nicotinic cholinergic receptor |
TBA |
| 19232492 |
32 |
Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors. |
Abbott Laboratories |
| 19027295 |
108 |
Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC). |
Copenhagen University |
| 18789861 |
26 |
Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators. |
Amgen |
| 16821801 |
35 |
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. |
Pfizer |
| 15771418 |
38 |
Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. |
University of Illinois At Chicago |
| 14684341 |
15 |
Synthesis and nicotinic receptor activity of a hydroxylated tropane. |
University of Wollongong |
| 14611837 |
18 |
Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity. |
University of Bristol |
| 32026697 |
111 |
Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine ?4?2 Receptor Antagonist for the Treatment of Depression. |
Suven Life Sciences |
| 27774124 |
76 |
Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds. |
Mahidol University |
| 30681854 |
50 |
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of ?7 and ?3* Nicotinic Receptors. |
University of Florence |
| 31434041 |
12 |
Discovery of fused heterocyclic carboxamide derivatives as novel ?7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. |
Peking University |
| 31021617 |
136 |
Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D |
University of Pennsylvania |
| 31299587 |
56 |
Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors. |
Universit£ |
| 31244109 |
36 |
Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency. |
University of Nottingham |
| 31276409 |
8 |
Alkaloids Purified from |
American University of Health Sciences |
| 25147147 |
101 |
Identification and pharmacological characterization of 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides as novel ligands for the ?4?2 and ?6/?3?2?3 nicotinic acetylcholine receptors (nAChRs). |
Targacept |
| 23352509 |
27 |
Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the ?3?4 nicotinic acetylcholine receptor (nAChR). |
Targacept |
| 11312774 |
36 |
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors. |
University of California |
| 31644280 |
1 |
Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics. |
Ponce De Leon Health |
| 19628399 |
13 |
Structural basis for alpha-conotoxin potency and selectivity. |
Boise State University |
| 15615518 |
10 |
Coaxing a pyridine nucleus to give up its aromaticity: synthesis and pharmacological characterization of novel conformationally restricted analogues of nicotine and anabasine. |
Indian Institute of Technology |
| 29671588 |
35 |
Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine. |
Indiana State University |
| 29634269 |
11 |
Drimane Sesquiterpenoids Noncompetitively Inhibit Human ?4?2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human ?3?4 and ?7 Subtypes. |
California Northstate University College of Medicine |
| 28838693 |
2 |
Design, synthesis, and biological activity of 5'-phenyl-1,2,5,6-tetrahydro-3,3'-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors. |
University of Michigan |
| 29751234 |
94 |
Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for ? |
Istituto Di Chimica Biomolecolare |
| 27810599 |
14 |
From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at?4?2 nicotinic acetylcholine receptor. |
Universit£ |
| 25626527 |
6 |
Novel Diketopiperazine Dihydroorotate Dehydrogenase Inhibitors Purified from Traditional Tibetan Animal Medicine Osteon Myospalacem Baileyi. |
Chinese Academy of Sciences |
| 26469307 |
7 |
Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b. |
University of Leipzig |
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