The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28174065 |
7 |
Synthesis of new derivatives of 21-imidazolyl-16-dehydropregnenolone as inhibitors of 5a-reductase 2 and with cytotoxic activity in cancer cells. |
Universidad Nacional Aut£Noma De M£Xico |
| 26780831 |
8 |
Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5a-reductase inhibitors. |
University Institute of Pharmaceutical Sciences |
| 26631442 |
6 |
Synthesis and activity of novel 16-dehydropregnenolone acetate derivatives as inhibitors of type 1 5a-reductase and on cancer cell line SK-LU-1. |
Universidad Nacional Aut£Noma De M£Xico |
| 25261928 |
17 |
Effect of dehydroepiandrosterone derivatives on the activity of 5a-reductase isoenzymes and on cancer cell line PC-3. |
National University of Mexico |
| 7837223 |
33 |
Benzophenone- and indolecarboxylic acids: potent type-2 specific inhibitors of human steroid 5 alpha-reductase. |
Smithkline Beecham Pharmaceuticals |
| 2308144 |
16 |
Steroidal A ring aryl carboxylic acids: a new class of steroid 5 alpha-reductase inhibitors. |
Smith Kline & French Laboratories |
| | 17 |
A non-steroidal diene acid inhibitor of human type 2 stereoid 5-reductase |
TBA |
| | 19 |
Preparative chiral HPLC separation of all possible stereoisomers of LY191704 and LY266111 and their in vitro inhibition of human types 1 and 2 steroid 5-reductases |
TBA |
| 22776417 |
7 |
Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5a-reductase inhibitors: a legitimate approach. |
Panjab University |
| 15828836 |
13 |
Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. |
University of Maryland |
| 12139451 |
41 |
Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors. |
Saarland University |
| 11063622 |
60 |
Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2. |
University of The Saarland |
| 11020287 |
32 |
Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1. |
Universit£ |
| 9135028 |
114 |
Pharmacological options in the treatment of benign prostatic hyperplasia. |
Pfizer |
| 9089333 |
37 |
19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. |
Universit£ |
| 7739004 |
12 |
Synthesis and in vitro evaluation of 4-substituted N-(1,1-dimethylethyl)-3-oxo-4-androstene-17 beta-carboxamides as 5 alpha-reductase inhibitors and antiandrogens. |
Chul Research Center |
| 7707319 |
81 |
Synthesis and in vitro activity of 17 beta-(N-alkyl/arylformamido)- and 17 beta-[(N-alkyl/aryl)alkyl/arylamido]-4-methyl-4-aza-3-oxo-5 alpha-androstan-3-ones as inhibitors of human 5 alpha-reductases and antagonists of the androgen receptor. |
Chul Research Center |
| 7650670 |
67 |
4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency. |
Merck Research Laboratories |
| 7629802 |
48 |
Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent. |
Glaxo Inc. Research Institute |
| 7966146 |
53 |
4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. |
Merck Research Laboratories |
| 8057283 |
126 |
6-Azasteroids: structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase. |
Glaxo Inc. Research Institute |
| 8381185 |
24 |
Nonsteroidal inhibitors of human type I steroid 5-alpha-reductase. |
Eli Lilly |
| 11425544 |
14 |
Biphenyls as surrogates of the steroidal backbone. Part 2: discovery of a novel family of non-steroidal 5-alpha-reductase inhibitors. |
Aventis |
| 9873639 |
12 |
Synthesis of benzo[c]quinolizin-3-ones: selective non-steroidal inhibitors of steroid 5 alpha-reductase 1. |
Universit£ |
| 21094046 |
4 |
Discovery of a novel hybrid from finasteride and epristeride as 5a-reductase inhibitor. |
College of Chemical and Environmental Engineering |
| | 3 |
The preparation and evaluation of (+/-)-trans-1-Diazo-8-methoxy-4a-methyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-2-one as an inhibitor of human type-1 steroid 5α-reductase |
TBA |
| | 33 |
A comparison of steroidal and non-steroidal inhibitors of human steroid 5α-reductase: New tricyclic aryl acid inhibitors of the type-1 isozyme |
TBA |
| | 8 |
Inhibition of steroid 5α-reductase by “inverted”, competitive inhibitors |
TBA |
| | 5 |
Inhibition of steroid 5α-reductase by 3-nitrosteroids: synthesis, mechanism of inhibition, and in vivo activity. |
TBA |
| 17490876 |
2 |
Evaluation of 4'-substituted bicyclic pyridones as non-steroidal inhibitors of steroid 5alpha-reductase. |
University of Canterbury |
| 16420060 |
12 |
Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. |
Saarland University |
| 15582428 |
47 |
Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5alpha-reductases 1 and 2. |
Polo Scientifico Università |
| 15214782 |
36 |
Synthesis, biological activity, and three-dimensional quantitative structure-activity relationship model for a series of benzo[c]quinolizin-3-ones, nonsteroidal inhibitors of human steroid 5alpha-reductase 1. |
University of Florence |
| 11087568 |
55 |
Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17). |
University of The Saarland |
| 10987415 |
18 |
Simple bi- and tricyclic inhibitors of human steroid 5alpha-reductase. |
University of Canterbury |
| 10714498 |
13 |
Synthesis of 8-chloro-benzo[c]quinolizin-3-ones as potent and selective inhibitors of human steroid 5alpha-reductase 1. |
Università |
| 10386944 |
7 |
N-substituted 4-(5-indolyl)benzoic acids. Synthesis and evaluation of steroid 5alpha-reductase type I and II inhibitory activity. |
UniversitäT Des Saarlandes |
| 29400967 |
136 |
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. |
Bristol-Myers Squibb |
| 9871692 |
25 |
Synthesis and 5 alpha-reductase inhibitory activity of 8-substituted benzo[f]quinolinones derived from palladium mediated coupling reactions. |
Eli Lilly |
| 9871560 |
17 |
Synthesis and 5 alpha-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group. |
Sankyo |
| 8277514 |
46 |
6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase. |
Glaxo Inc. Research Institute |
| 2308145 |
48 |
Inhibition of steroid 5 alpha-reductase by unsaturated 3-carboxysteroids. |
Smith Kline & French Laboratories |
| 28757062 |
6 |
Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5?-androst-17?-amide derivatives as dual 5?-reductase inhibitors and androgen receptor antagonists. |
China Pharmaceutical University |
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