36 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27690432	75	Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986).	Charles River Discovery Research Services
27211244	9	Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium.	University of Florida
25782742	76	trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: prime site exploration using an amino linker.	Novartis Pharma
25754490	44	trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.	Novartis Pharma
25728416	25	Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.	Merck Research Laboratories
25086681	57	Structure-based optimization of non-peptidic Cathepsin D inhibitors.	Merck
25050166	58	Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.	Novartis Institutes For Biomedical Research
25363711	62	Inhibitors ofß-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).	Amgen
23590342	105	ß-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.	F. Hoffmann-La Roche
23425156	24	The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.	Novartis Pharma
23360239	19	A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.	Novartis Pharma
23181502	57	Cyanobacterial peptides as a prototype for the design of potentß-secretase inhibitors and the development of selective chemical probes for other aspartic proteases.	University of Florida
24900544	8	Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.	TBA
22748705	2	Total synthesis of grassystatin A, a probe for cathepsin E function.	Fudan University
22360587	1	Symplocin A, a linear peptide from the Bahamian cyanobacterium Symploca sp. Configurational analysis of N,N-dimethylamino acids by chiral-phase HPLC of naphthacyl esters.	University of California
19715320	87	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.	University of Florida
17980584	72	Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor.	Schering-Plough Research Institute
18023580	50	Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.	Schering-Plough Research Institute
2002469	80	Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.	Merck Sharp and Dohme Research Laboratories
	37	Peptidomimetic inhibitors of human immunodeficiency virus protease (HIV-PR): Design, enzyme binding and selectivity, antiviral efficacy, and cell permeability properties	TBA
20731374	65	Direct renin inhibitors as a new therapy for hypertension.	Novartis Pharmaceuticals
20347593	76	Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.	Merck Research Laboratories
20102207	7	Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent.	China Medical University
19963375	30	Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.	Novartis Institutes For Biomedical Research
	22	Novel pseudosymmetric inhibitors of HIV-1 protease	TBA
18468890	69	Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.	Schering-Plough Research Institute
31913032	86	Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present).	University of Zambia
31589043	91	Discovery of AM-6494: A Potent and Orally Efficacious ?-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2.	TBA
8410992	35	Renin inhibitors containing a pyridyl amino diol derived C-terminus.	Hoechst
8410973	75	Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.	University of Florida
29087712	34	Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer.	University of Florida