The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
1433224 |
1 |
Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake. |
Warner-Lambert |
2544727 |
1 |
Sodium channel binding and anticonvulsant activities for the enantiomers of a bicyclic 2,4-oxazolidinedione and monocyclic models. |
University of Alabama |
2846842 |
14 |
Anticonvulsant activities of phenyl-substituted bicyclic 2,4-oxazolidinediones and monocyclic models. Comparison with binding to the neuronal voltage-dependent sodium channel. |
University of Alabama |
15177465 |
18 |
2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. |
Institut Henri Beaufour |
10406642 |
8 |
Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety. |
Pharmacia & Upjohn |
25927480 |
36 |
Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications. |
Merck Research Laboratories |
25026046 |
42 |
Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels. |
Purdue Pharma |
19388676 |
21 |
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. |
Johnson & Johnson Pharmaceutical Research & Development |
9703475 |
19 |
Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. |
Cambridge Neuroscience |
9685245 |
22 |
Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels. |
Cambridge Neuroscience |
8295214 |
21 |
Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers. |
Warner-Lambert |
10571163 |
14 |
A novel class of Na+ and Ca2+ channel dual blockers with highly potent anti-ischemic effects. |
Institute For Bio-Medical Research |
10498200 |
40 |
Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants. |
Pharmacia & Upjohn |
| 15 |
Batrachotoxin binding site antagonists |
TBA |
21962108 |
14 |
Lactam-stabilized helical analogues of the analgesicµ-conotoxin KIIIA. |
Monash University |
18640044 |
24 |
Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'CJ-17,493'. |
Pfizer |
17724025 |
8 |
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. |
University of Utah |
15080972 |
64 |
The design, preparation and SAR of novel small molecule sodium (Na(+)) channel blockers. |
Arqule |
31117524 |
1 |
Isolation and Biological Activity of 8- Epitetrodotoxin and the Structure of a Possible Biosynthetic Shunt Product of Tetrodotoxin, Cep-226A, from the Newt Cynops ensicauda popei. |
Tohoku University |
8691482 |
25 |
A structure-activity relationship study of novel phenylacetamides which are sodium channel blockers. |
Warner-Lambert |
23910595 |
3 |
Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels. |
Institute of Nuclear Medicine |
23707919 |
7 |
Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker ?-KIIIA and its selenopeptide analogues. |
University of Gdansk |
12166948 |
77 |
Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke. |
Boehringer Ingelheim Pharma |
10229624 |
25 |
Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel. |
University of Alabama At Birmingham |
10411478 |
5 |
Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. |
Bial |
9046351 |
13 |
Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel. |
University of Alabama At Birmingham |
7562939 |
7 |
Synthesis and anticonvulsant activity of enaminones. 3. Investigations on 4'-, 3'-, and 2'-substituted and polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluations. |
Howard University |
7932556 |
11 |
Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel. |
University of Alabama At Birmingham |
29116786 |
265 |
Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies. |
Idorsia Pharmaceuticals |