The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 24593905 |
16 |
Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists. |
Glaxosmithkline |
| 23562062 |
4 |
Arylsulfonamide pyrimidines as VLA-4 antagonists. |
Elan Pharmaceuticals |
| 23339734 |
4 |
Design, synthesis, and functional evaluation of leukocyte function associated antigen-1 antagonists in early and late stages of cancer development. |
Ikerchem |
| 17125246 |
11 |
Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1. |
Cerep |
| 24900456 |
46 |
Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. |
TBA |
| 15214773 |
76 |
Fragment-based drug discovery. |
Sunesis Pharmaceuticals |
| 12139455 |
78 |
Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents. |
Genentech |
| 12643901 |
42 |
N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship. |
Genentech |
| 21109434 |
40 |
Structure-activity relationship (SAR) of thea-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. |
Sunesis Pharmaceuticals |
| 20655213 |
31 |
Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. |
Sunesis Pharmaceuticals |
| 20405922 |
53 |
Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521). |
Bristol-Myers Squibb Research And Development |
| 7852999 |
6 |
Cucurbitacins, Cell Adhesion Inhibitors from Conobea scoparioides |
TBA |
| 9322361 |
1 |
Four new clerodane diterpenes from the leaves of Casearia guianensis which inhibit the interaction of leukocyte function antigen 1 with intercellular adhesion molecule 1. |
Searle Research And Development |
| 18783948 |
31 |
Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors. |
Biogen Idec |
| 18778938 |
20 |
Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors. |
Biogen Idec |
| 15686945 |
19 |
1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1. |
Novartis Institutes For Biomedical Research |
| 15686933 |
12 |
De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold. |
Cerep |
| 15582439 |
84 |
Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding. |
Abbott Laboratories |
| 15481974 |
43 |
Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives. |
Boehringer Ingelheim Pharmaceuticals |
| 15109637 |
30 |
Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain. |
Novartis Institutes For Biomedical Research |
| 15080978 |
66 |
N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety. |
Genentech |
| 12565959 |
9 |
1,4-Diazepane-2-ones as novel inhibitors of LFA-1. |
Novartis Institute For Biomedical Research |
| 11728185 |
55 |
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide. |
Abbott Laboratories |
| 11520199 |
25 |
Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides. |
Abbott Laboratories |
| 11327603 |
31 |
Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists. |
Abbott Laboratories |
| 11312920 |
23 |
Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties. |
Abbott Laboratories |
| 11052808 |
75 |
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. |
Abbott Laboratories |
| 10853677 |
34 |
Discovery and evaluation of potent, tyrosine-based alpha4beta1 integrin antagonists. |
Celltech Chiroscience |
| 10072689 |
39 |
Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. |
Biogen |
| 7707308 |
3 |
Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. |
R. W. Johnson Pharmaceutical Research Institute |
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