The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
25127101 |
26 |
Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists. |
Dainippon Sumitomo Pharma |
22708876 |
106 |
Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-ß-alanine (MK-0893) for the treatment of type II diabetes. |
Merck Research Laboratories |
11543679 |
15 |
A new approach to search for the bioactive conformation of glucagon: positional cyclization scanning. |
University of Arizona |
10794689 |
10 |
Design and synthesis of conformationally constrained glucagon analogues. |
University of Arizona |
9258362 |
30 |
The role of phenylalanine at position 6 in glucagon's mechanism of biological action: multiple replacement analogues of glucagon. |
University of Arizona |
8691441 |
19 |
Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences. |
University of Arizona |
21147532 |
82 |
Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core. |
Merck Research Laboratories |
| 2 |
[des His1, des Phe6, Glu9]glucagon amide: A newly designed “pure” glucagon antagonist |
TBA |
| 1 |
CP-99,711: a non-peptide glucagon receptor antagonist |
TBA |
18707090 |
68 |
Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor. |
Novo Nordisk |
17201415 |
47 |
New beta-alanine derivatives are orally available glucagon receptor antagonists. |
Novo Nordisk |
12477359 |
78 |
Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide. |
Novo Nordisk |
11844695 |
35 |
Human glucagon receptor antagonists based on alkylidene hydrazides. |
Pfizer |
11543683 |
42 |
Identification of alkylidene hydrazides as glucagon receptor antagonists. |
Pfizer |
11311060 |
12 |
Development of potent truncated glucagon antagonists. |
University of Arizona |