BindingDB PrimarySearch

BDBM50336507 4-pyridinecarbohydrazide(Isoniazid)::CHEMBL64::Dow-isoniazid::Hyzyd::INH::ISONICOTINIC ACID HYDRAZIDE(ISONIAZIDE)::Isoniazid (INH)::Isonicotinic acid hydrazide (Isoniazid)::Isonicotinic acid hydrazide(Isoniazid)::Isonicotinylhydrazine::Laniazid::Nydrazid::Rimifon::Stanozide::isoniazid::isonicotinamide::isonicotinhydrazide::isonicotinohydrazide::isonicotinyl hydrazide::pyridine-4-carbohydrazide

SMILES: NNC(=O)c1ccncc1

InChI Key: InChIKey=QRXWMOHMRWLFEY-UHFFFAOYSA-N

Data: 7 KI 22 IC50

PDB links: 12 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50336507
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydrofolate reductase (Mycobacterium tuberculosis)	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Texas A&M University Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis dihydrofolate reductase				Antimicrob Agents Chemother 54: 3776-82 (2010) Article DOI: 10.1128/AAC.00453-10 BindingDB Entry DOI: 10.7270/Q2F47PFS
Texas A&M University Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	DrugBank PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Mechanism based inhibition of human cytochrome P450 2C19 evaluated using Tolbutamide				Curr Drug Metab 6: 413-54 (2005) BindingDB Entry DOI: 10.7270/Q2VQ33X3
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	DrugBank PubMed	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Mechanism based inhibition of human cytochrome P450 3A4 measured by testosterone 6-beta hydroxylation using human liver microsomes				Curr Drug Metab 6: 413-54 (2005) BindingDB Entry DOI: 10.7270/Q2VQ33X3
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 1A (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	DrugBank PubMed	5.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Mechanism based inhibition of human cytochrome P450 1A2 measured by formation of 6-hydroxywarfarin				Curr Drug Metab 6: 413-54 (2005) BindingDB Entry DOI: 10.7270/Q2VQ33X3
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2A6 (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	DrugBank PubMed	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Mechanism based inhibition of human cytochrome P450 2A6 measured by coumarin 7-hydroxylation				Curr Drug Metab 6: 413-54 (2005) BindingDB Entry DOI: 10.7270/Q2VQ33X3
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C8 (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	DrugBank PubMed	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using human liver microsomes				Curr Drug Metab 6: 413-54 (2005) BindingDB Entry DOI: 10.7270/Q2VQ33X3
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C8 (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	DrugBank PubMed	3.74E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using a recombinant system				Curr Drug Metab 6: 413-54 (2005) BindingDB Entry DOI: 10.7270/Q2VQ33X3
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-ketoacyl-ACP synthase III (FabH) (Escherichia coli)	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of Escherichia coli KAS3 expressed in Escherichia coli BL21(DE3)				Bioorg Med Chem 27: 1509-1516 (2019) Article DOI: 10.1016/j.bmc.2019.02.043
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair
Myeloperoxidase (MPO) (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Libre de Bruxelles (ULB) Curated by ChEMBL					Assay Description Irreversible inhibition of MPO (unknown origin)				ACS Med Chem Lett 8: 206-210 (2017) Article DOI: 10.1021/acsmedchemlett.6b00417 BindingDB Entry DOI: 10.7270/Q28K7C3H
Universit£ Libre de Bruxelles (ULB) Curated by ChEMBL					More data for this Ligand-Target Pair
Myeloperoxidase (MPO) (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Libre de Bruxelles (ULB) Curated by ChEMBL					Assay Description Inhibition of human MPO				ACS Med Chem Lett 8: 206-210 (2017) Article DOI: 10.1021/acsmedchemlett.6b00417 BindingDB Entry DOI: 10.7270/Q28K7C3H
Universit£ Libre de Bruxelles (ULB) Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (BSEP) (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis				Toxicol Sci 118: 485-500 (2010) Article DOI: 10.1093/toxsci/kfq269 BindingDB Entry DOI: 10.7270/Q26Q20JN
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...				Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 2 (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	Reactome pathway KEGG DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 1 (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Multidrug resistance-associated protein 4 (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	Reactome pathway KEGG DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Birla Institute of Technology & Science-Pilani Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3) by spectrophotometry				Bioorg Med Chem 22: 4223-32 (2014) Article DOI: 10.1016/j.bmc.2014.05.038 BindingDB Entry DOI: 10.7270/Q2D79FDX
					More data for this Ligand-Target Pair
DNA gyrase subunit B (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Technology & Science-Pilani Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of DNA supercoiling after 30 mins by electrophoresis				Bioorg Med Chem 24: 877-85 (2016) Article DOI: 10.1016/j.bmc.2016.01.011 BindingDB Entry DOI: 10.7270/Q2MP5682
Institute of Technology & Science-Pilani Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Kyungpook National University Curated by ChEMBL					Assay Description Inhibition of mushroom tyrosinase using L-tyrosine as substrate				Eur J Med Chem 106: 157-66 (2015) Article DOI: 10.1016/j.ejmech.2015.10.033 BindingDB Entry DOI: 10.7270/Q2514270
Kyungpook National University Curated by ChEMBL					More data for this Ligand-Target Pair
Enoyl-[acyl-carrier-protein] reductase [NADH] (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	DrugBank Article PubMed	n/a	n/a	8.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of recombinant Mycobacterium tuberculosis InhA expressed in Escherichia coli Rosette(DE3) pLysS using trans-2-decenoyl-N-acetylcysteamine ...				Bioorg Med Chem 27: 1509-1516 (2019) Article DOI: 10.1016/j.bmc.2019.02.043
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair
DNA Gyrase (Escherichia coli (strain K12))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of Escherichia coli DNA gyrase assessed as reduction in enzyme-mediated supercoiling of relaxed pBR322 DNA measured after 60 mins by elect...				Bioorg Med Chem 27: 1509-1516 (2019) Article DOI: 10.1016/j.bmc.2019.02.043
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Birla Institute of Technology& Science-Pilani Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ format...				Bioorg Med Chem 24: 1298-307 (2016) BindingDB Entry DOI: 10.7270/Q2C82C5B
					More data for this Ligand-Target Pair
Bile salt export pump (Rattus norvegicus)	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	KEGG GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...				Drug Metab Dispos 40: 130-8 (2011) Article DOI: 10.1124/dmd.111.040758 BindingDB Entry DOI: 10.7270/Q20Z7500
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (BSEP) (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake				Drug Metab Dispos 40: 130-8 (2011) Article DOI: 10.1124/dmd.111.040758 BindingDB Entry DOI: 10.7270/Q20Z7500
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Isocitrate lyase (ICL) (Mycobacterium tuberculosis)	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>4.56E+5	n/a	n/a	n/a	n/a	n/a	37
Birla Institute of Technology & Science-Pilani, Hyderabad Campus					Assay Description Isocitrate lyase activity was determined at 37°C by measuringthe formation of glyoxylate phenylhydrazone at 324 nm [Bai et al., Drug Dev. Res., 6...				J Enzyme Inhib Med Chem 25: 765-72 (2010) Article DOI: 10.3109/14756360903425221 BindingDB Entry DOI: 10.7270/Q28914R3
					More data for this Ligand-Target Pair
MymA (Mycobacterium tuberculosis)	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Miranda House					Assay Description Inhibition of MymA activity by INH was checked using different concentrations (0�12 μm) of INH, 100 μm of trimeth- ylamine and 5 mg of MymA...				Chem Biol Drug Des 89: 152-160 (2017) Article DOI: 10.1111/cbdd.12840 BindingDB Entry DOI: 10.7270/Q2416VWG
Miranda House					More data for this Ligand-Target Pair
8-Oxoguanine DNA glycosylase-1 (OGG1) (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB KEGG GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 �L of OGG1 (125 nM) was mixed with 1 �L of inhibitor. In a separate tube, 1 �L of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
Oregon Health & Science University					More data for this Ligand-Target Pair
8-Oxoguanine DNA glycosylase-1 (OGG1) (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB KEGG GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Oregon Health & Science University					Assay Description Gel-based assays were performed by combining 4 �L of OGG1 (62.5 nM) with 1 �L of inhibitor or buffer. Substrate (5 �L, 50 nM) was added to bring the ...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
Oregon Health & Science University					More data for this Ligand-Target Pair
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) \| CHEMBL64 \| D...) Show SMILES NNC(=O)c1ccncc1 Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Birla Institute of Technology& Science-Pilani Curated by ChEMBL					Assay Description Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3)				Bioorg Med Chem 22: 1938-47 (2014) Article DOI: 10.1016/j.bmc.2014.01.030 BindingDB Entry DOI: 10.7270/Q2222W9G
					More data for this Ligand-Target Pair