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BDBM29532 (1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-1,6-diene-3,5-dione::(1E,6E)-1,7-bis(4-hydroxy-3-methoxy-phenyl)hepta-1,6-diene-3,5-dione::(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione::CHEMBL140::CURCUMIN::Curcurmin::Diferuloylmethane::MLS000069631::Natural yellow 3::SMR000058237::Turmeric yellow::cid_969516
SMILES: COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O
InChI Key: InChIKey=VFLDPWHFBUODDF-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 (5-HT4) (Homo sapiens (Human)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
CNRS | Assay Description EC/IC50 was the effective concentration of agonist inhibiting the formation of A-beta fibrils to 50% of the control value. Three independent measurem... | J Med Chem 52: 2214-25 (2009) Article DOI: 10.1021/jm801327q BindingDB Entry DOI: 10.7270/Q2QF8R6F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prostaglandin E synthase (Homo sapiens (Human)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.88E+3 | n/a | n/a | n/a | n/a | 7.0 | 20 |
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia | Assay Description The assay buffer contained 100 mM KHPO4 (pH 7.0), 2 mM EDTA and 2.5 mM reduced GSH. 100 µL of reaction buffer containing human recombinant mPGES... | Chem Biol Drug Des 83: 670-81 (2014) Article DOI: 10.1111/cbdd.12280 BindingDB Entry DOI: 10.7270/Q26H4G2V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Genome polyprotein (West Nile virus) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay | Assay Description The HTS assay to identify Inhibitors of West Nile Virus (WNV) NS2bNS3 Proteinase was proposed by Dr Alex Strongin of the Burnham Institute XO1-MH0776... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2222S6W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase 3 (Homo sapiens (Human)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2JW8C95 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Intestinal alkaline phosphatase (Homo sapiens (Human)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2X63KDM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alkaline phosphatase placental-like (Homo sapiens (Human)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2NS0SCW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alkaline phosphatase, tissue-nonspecific isozyme (Homo sapiens (Human)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2H130G1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpi (Rattus norvegicus (Rat)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.87E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2DB809V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| TPA: Essential protein of the mitochondrial intermembrane space (Saccharomyces cerevisiae S288c) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2F18X6W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| perilipin-1 (Homo sapiens (Human)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 9.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2HT2MS2 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| perilipin-5 (Homo sapiens (Human)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2D21W3H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Toll-like receptor 9 (Homo sapiens (Human)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 8.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2KS6Q2P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta lactamase (Pseudomonas aeruginosa) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 7.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2G15ZB8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| hypothetical protein SA1422 (Staphylococcus aureus subsp. aureus N315) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 6.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | PubChem Bioassay (2012) BindingDB Entry DOI: 10.7270/Q2BV7F7H | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Phospholipase A2 (Homo sapiens (Human)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.11E+4 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia | Assay Description Substrate 1,2-bis(heptanoylthio)-glycerophosphocholine and human recombinant PLA2-V were resuspended in assay buffer, and DTNB was dissolved in an aq... | Chem Biol Drug Des 83: 670-81 (2014) Article DOI: 10.1111/cbdd.12280 BindingDB Entry DOI: 10.7270/Q26H4G2V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.13E+4 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia | Assay Description Reaction mixture containing 100 mM Tris-HCl buffer (pH 8) and COX-1 (ovine) or COX-2 (human recombinant) was preincubated for 10 min in a water bath ... | Chem Biol Drug Des 83: 670-81 (2014) Article DOI: 10.1111/cbdd.12280 BindingDB Entry DOI: 10.7270/Q26H4G2V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclooxygenase (Homo sapiens (Human)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9.64E+4 | n/a | n/a | n/a | n/a | 8.0 | 37 |
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia | Assay Description Reaction mixture containing 100 mM Tris-HCl buffer (pH 8) and COX-1 (ovine) or COX-2 (human recombinant) was preincubated for 10 min in a water bath ... | Chem Biol Drug Des 83: 670-81 (2014) Article DOI: 10.1111/cbdd.12280 BindingDB Entry DOI: 10.7270/Q26H4G2V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Lipoxygenase (LOX) (Glycine max (Soybean)) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.78E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia | Assay Description The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ... | Chem Biol Drug Des 83: 670-81 (2014) Article DOI: 10.1111/cbdd.12280 BindingDB Entry DOI: 10.7270/Q26H4G2V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...) | BDBM29532 ((1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.03E+4 | n/a | n/a | n/a | n/a | 8.0 | 23 |
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay | Assay Description A fluorescence resonance energy transfer assay is developed in 96-well and 384-well microplate formats with robotic manipulation to enable high-throu... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2H70D5W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
