BDBM135812 US10085990, Example 30::US10568888, Example 30::US8853226, 30::US9393245, 30::US9833457, 30
SMILES: CCn1c(=O)n(C2CCCC2)c2c3cccc(Cl)c3ncc2c1=O
InChI Key: InChIKey=RNTPXDNXVJTNNP-UHFFFAOYSA-N
Data: 12 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
High Point Pharmaceuticals, LLC US Patent | Assay Description A TR-FRET-based phosphodiesterase assay kit from "Molecular Devices" was used to test whether these compounds were indeed direct inhibitors of the PD... | US Patent US8853226 (2014) BindingDB Entry DOI: 10.7270/Q28C9TZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
High Point Pharmaceuticals, LLC US Patent | Assay Description A TR-FRET-based phosphodiesterase assay kit from "Molecular Devices" was used to test whether these compounds were indeed direct inhibitors of the PD... | US Patent US8853226 (2014) BindingDB Entry DOI: 10.7270/Q28C9TZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tumor necrosis factor (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
vTv Therapeutics LLC US Patent | Assay Description Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro... | US Patent US9393245 (2016) BindingDB Entry DOI: 10.7270/Q2JH3K2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
phosphodiesterase 4B2 (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | 30 |
vTv Therapeutics LLC US Patent | Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe... | US Patent US9393245 (2016) BindingDB Entry DOI: 10.7270/Q2JH3K2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
phosphodiesterase 4D (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | 30 |
vTv Therapeutics LLC US Patent | Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe... | US Patent US9393245 (2016) BindingDB Entry DOI: 10.7270/Q2JH3K2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
vTv Therapeutics LLC US Patent | Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn... | US Patent US10568888 (2020) BindingDB Entry DOI: 10.7270/Q2ST7S7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
vTv Therapeutics LLC US Patent | Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn... | US Patent US10085990 (2018) BindingDB Entry DOI: 10.7270/Q2RV0QRM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
vTv Therapeutics LLC US Patent | Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn... | US Patent US10085990 (2018) BindingDB Entry DOI: 10.7270/Q2RV0QRM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
vTv Therapeutics LLC US Patent | Assay Description A TR-FRET-based phosphodiesterase assay kit from Molecular Devices was used to test whether these compounds were indeed direct inhibitors of the PDE4... | US Patent US9833457 (2017) BindingDB Entry DOI: 10.7270/Q26W9DB9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
vTv Therapeutics LLC US Patent | Assay Description A TR-FRET-based phosphodiesterase assay kit from Molecular Devices was used to test whether these compounds were indeed direct inhibitors of the PDE4... | US Patent US9833457 (2017) BindingDB Entry DOI: 10.7270/Q26W9DB9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
vTv Therapeutics LLC US Patent | Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn... | US Patent US10568888 (2020) BindingDB Entry DOI: 10.7270/Q2ST7S7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (Homo sapiens (Human)) | BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
vTv Therapeutics LLC US Patent | Assay Description Samples were tested for TNF as per the manufacturer's instructions (TNF ELISA; R&D Systems, Cat #DY210). The samples were serially diluted with P... | US Patent US10085990 (2018) BindingDB Entry DOI: 10.7270/Q2RV0QRM | |||||||||||
More data for this Ligand-Target Pair |