Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4D' and Ligand = 'BDBM135812'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(Cl)c3ncc2c1=O Show InChI InChI=1S/C18H18ClN3O2/c1-2-21-17(23)13-10-20-15-12(8-5-9-14(15)19)16(13)22(18(21)24)11-6-3-4-7-11/h5,8-11H,2-4,6-7H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
High Point Pharmaceuticals, LLC US Patent					Assay Description A TR-FRET-based phosphodiesterase assay kit from "Molecular Devices" was used to test whether these compounds were indeed direct inhibitors of the PD...				US Patent US8853226 (2014) BindingDB Entry DOI: 10.7270/Q28C9TZS
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(Cl)c3ncc2c1=O Show InChI InChI=1S/C18H18ClN3O2/c1-2-21-17(23)13-10-20-15-12(8-5-9-14(15)19)16(13)22(18(21)24)11-6-3-4-7-11/h5,8-11H,2-4,6-7H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...				US Patent US10568888 (2020) BindingDB Entry DOI: 10.7270/Q2ST7S7B
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(Cl)c3ncc2c1=O Show InChI InChI=1S/C18H18ClN3O2/c1-2-21-17(23)13-10-20-15-12(8-5-9-14(15)19)16(13)22(18(21)24)11-6-3-4-7-11/h5,8-11H,2-4,6-7H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
vTv Therapeutics LLC US Patent					Assay Description A TR-FRET-based phosphodiesterase assay kit from Molecular Devices was used to test whether these compounds were indeed direct inhibitors of the PDE4...				US Patent US9833457 (2017) BindingDB Entry DOI: 10.7270/Q26W9DB9
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM135812 (US10085990, Example 30 | US10568888, Example 30 | ...) Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(Cl)c3ncc2c1=O Show InChI InChI=1S/C18H18ClN3O2/c1-2-21-17(23)13-10-20-15-12(8-5-9-14(15)19)16(13)22(18(21)24)11-6-3-4-7-11/h5,8-11H,2-4,6-7H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	25
vTv Therapeutics LLC US Patent					Assay Description The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...				US Patent US10085990 (2018) BindingDB Entry DOI: 10.7270/Q2RV0QRM
					More data for this Ligand-Target Pair