Found 60 hits for monomerid = 18355 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01673 BindingDB Entry DOI: 10.7270/Q23J3HVM |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
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| | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Rattus norvegicus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Competitive Inhibitory activity against Golgi Alpha-mannosidase II |
J Med Chem 38: 2349-56 (1995)
BindingDB Entry DOI: 10.7270/Q2N878T0 |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| 1.16E+5 | -5.58 | 2.70E+5 | n/a | n/a | n/a | n/a | 5.5 | 37 |
Hokuriku University
| Assay Description Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4... |
Bioorg Med Chem 14: 7736-44 (2006)
Article DOI: 10.1016/j.bmc.2006.08.003 BindingDB Entry DOI: 10.7270/Q2BZ649B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-mannosidase
(Bacteroides thetaiotaomicron) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB MMDB
KEGG
UniProtKB/TrEMBL
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| 6.00E+6 | -3.15 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
The Medical School, Newcastle University
| Assay Description Putative mannosidase assay using wild-type protein Btman2A. Enzyme inhibition assay. |
Nat Chem Biol 4: 306-12 (2008)
Article DOI: 10.1038/nchembio.81 BindingDB Entry DOI: 10.7270/Q2X34VS6 |
More data for this Ligand-Target Pair | |
Lactase/phlorizin hydrolase
(Rattus norvegicus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method |
J Med Chem 38: 2349-56 (1995)
BindingDB Entry DOI: 10.7270/Q2N878T0 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2C1
(Rattus norvegicus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | KEGG
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of soluble Alpha-mannosidase II in rat liver |
J Med Chem 38: 2349-56 (1995)
BindingDB Entry DOI: 10.7270/Q2N878T0 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Rattus norvegicus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB MMDB
KEGG
UniProtKB/TrEMBL
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| n/a | n/a | <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of lysosomal Alpha-mannosidase II in rat liver |
J Med Chem 38: 2349-56 (1995)
BindingDB Entry DOI: 10.7270/Q2N878T0 |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method |
J Med Chem 38: 2349-56 (1995)
BindingDB Entry DOI: 10.7270/Q2N878T0 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Rattus norvegicus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of golgi Alpha-mannosidase II in rat liver |
J Med Chem 38: 2349-56 (1995)
BindingDB Entry DOI: 10.7270/Q2N878T0 |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of sucrase by HPLC |
J Med Chem 53: 689-98 (2010)
Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of human lysosomal alpha glucosidase |
Bioorg Med Chem Lett 19: 6600-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.022 BindingDB Entry DOI: 10.7270/Q2736QZB |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| n/a | n/a | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry |
J Med Chem 57: 9096-104 (2014)
Article DOI: 10.1021/jm501181z BindingDB Entry DOI: 10.7270/Q20003PT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Non-lysosomal glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of GBA2 (unknown origin) |
J Med Chem 57: 9096-104 (2014)
Article DOI: 10.1021/jm501181z BindingDB Entry DOI: 10.7270/Q20003PT |
More data for this Ligand-Target Pair | |
Ceramide glucosyltransferase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | NCI pathway Reactome pathway KEGG
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| DrugBank Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide |
J Med Chem 57: 9096-104 (2014)
Article DOI: 10.1021/jm501181z BindingDB Entry DOI: 10.7270/Q20003PT |
More data for this Ligand-Target Pair | |
Non-lysosomal glucosylceramidase
(Mus musculus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of conduritol beta-epoxide-sensitive mouse glucosylceramidase |
J Biol Chem 282: 32655-64 (2007)
Article DOI: 10.1074/jbc.M702387200 BindingDB Entry DOI: 10.7270/Q2QJ7H2D |
More data for this Ligand-Target Pair | |
Ceramide glucosyltransferase
(Mus musculus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 2.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition mouse glucosylceramide synthase |
J Biol Chem 282: 32655-64 (2007)
Article DOI: 10.1074/jbc.M702387200 BindingDB Entry DOI: 10.7270/Q2QJ7H2D |
More data for this Ligand-Target Pair | |
Non-lysosomal glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of human GBA2 |
Bioorg Med Chem Lett 19: 6600-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.022 BindingDB Entry DOI: 10.7270/Q2736QZB |
More data for this Ligand-Target Pair | |
Ceramide glucosyltransferase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of GCS by cell-based assay |
J Med Chem 53: 689-98 (2010)
Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC |
More data for this Ligand-Target Pair | |
Lactase/phlorizin hydrolase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of lactase by HPLC |
J Med Chem 53: 689-98 (2010)
Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC |
More data for this Ligand-Target Pair | |
Non-lysosomal glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of GBA2 by HPLC |
J Med Chem 53: 689-98 (2010)
Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of lysosomal alpha-glucosidase by HPLC |
J Med Chem 53: 689-98 (2010)
Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC |
More data for this Ligand-Target Pair | |
Glycogen debranching enzyme
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of glycogen glycogen de-branching enzyme by HPLC |
J Med Chem 53: 689-98 (2010)
Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC |
More data for this Ligand-Target Pair | |
Maltase-glucoamylase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of maltase by HPLC |
J Med Chem 53: 689-98 (2010)
Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| n/a | n/a | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay |
ACS Med Chem Lett 2: 119-123 (2011)
Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Ceramide glucosyltransferase
(Mus musculus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay |
ACS Med Chem Lett 2: 119-123 (2011)
Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Mus musculus (Mouse)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of maltase in mouse intestinal input by glucose release assay |
ACS Med Chem Lett 2: 119-123 (2011)
Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H |
More data for this Ligand-Target Pair | |
Beta-galactosidase
(Mus musculus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 7.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of lactase in mouse intestinal input by glucose release assay |
ACS Med Chem Lett 2: 119-123 (2011)
Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase
(Mus musculus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of sucrase in mouse intestinal input by glucose release assay |
ACS Med Chem Lett 2: 119-123 (2011)
Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H |
More data for this Ligand-Target Pair | |
Non-lysosomal glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of recombinant GBA2 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay |
ACS Med Chem Lett 2: 119-123 (2011)
Article DOI: 10.1021/ml100192b BindingDB Entry DOI: 10.7270/Q21C1X5H |
More data for this Ligand-Target Pair | |
Ceramide glucosyltransferase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of GCS assessed as amount of UDP-glucose consumed during enzyme-catalyzed reaction |
Bioorg Med Chem Lett 21: 6773-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.037 BindingDB Entry DOI: 10.7270/Q2833SG2 |
More data for this Ligand-Target Pair | |
Ceramide glucosyltransferase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank Article PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of GCS assessed as amount of UDP glucose after 3 hrs by Fluorometry analysis |
J Med Chem 55: 4322-35 (2012)
Article DOI: 10.1021/jm300122u BindingDB Entry DOI: 10.7270/Q2MG7QMF |
More data for this Ligand-Target Pair | |
Non-lysosomal glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of non-lysosomal glucosylceramidase in cultured melanoma cells |
Eur J Med Chem 46: 1949-63 (2011)
Article DOI: 10.1016/j.ejmech.2011.01.047 BindingDB Entry DOI: 10.7270/Q22808QQ |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ d'Orl£ans
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal maltase using disaccharide |
Bioorg Med Chem Lett 14: 5991-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.086 BindingDB Entry DOI: 10.7270/Q27P904W |
More data for this Ligand-Target Pair | |
Putative alpha-glucosidase
(Oryza sativa subsp. japonica) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ d'Orl£ans
Curated by ChEMBL
| Assay Description Inhibitory activity against alpha-Glucosidase from rice |
Bioorg Med Chem Lett 14: 5991-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.086 BindingDB Entry DOI: 10.7270/Q27P904W |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ d'Orl£ans
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal sucrase using disaccharide |
Bioorg Med Chem Lett 14: 5991-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.086 BindingDB Entry DOI: 10.7270/Q27P904W |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ d'Orl£ans
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal isomaltase using disaccharide |
Bioorg Med Chem Lett 14: 5991-5 (2004)
Article DOI: 10.1016/j.bmcl.2004.09.086 BindingDB Entry DOI: 10.7270/Q27P904W |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| n/a | n/a | 2.59E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of human placental beta-glucocerebrosidase |
J Med Chem 52: 3146-9 (2009)
Article DOI: 10.1021/jm801506m BindingDB Entry DOI: 10.7270/Q26W9CBW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Trehalase
(Sus scrofa) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of porcine kidney trehalase |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this Ligand-Target Pair | |
Trehalase
(Rattus norvegicus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal trehalase |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this Ligand-Target Pair | |
Lactase/phlorizin hydrolase
(Rattus norvegicus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 2.74E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal lactase using lactose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| n/a | n/a | 3.99E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of human beta-glucocerebrosidase |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal sucrase using sucrose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase, intestinal
(Rattus norvegicus (Rat)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal isomaltase using isomoltose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal maltase using moltose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this Ligand-Target Pair | |
Ceramide glucosyltransferase
(Mus musculus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of glucosylceramide synthase in mouse RAW cells preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluores... |
ACS Med Chem Lett 2: 519-522 (2011)
Article DOI: 10.1021/ml200050s BindingDB Entry DOI: 10.7270/Q28916V8 |
More data for this Ligand-Target Pair | |
Non-lysosomal glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of glucosylceramidase 2 from spleen of patient with gaucher's disease by fluorimetric analysis |
ACS Med Chem Lett 2: 519-522 (2011)
Article DOI: 10.1021/ml200050s BindingDB Entry DOI: 10.7270/Q28916V8 |
More data for this Ligand-Target Pair | |
Sucrase-isomaltase
(Mus musculus) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | UniProtKB/TrEMBL
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Patents
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| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Napoli Federico II
Curated by ChEMBL
| Assay Description Inhibition of wild type C57BL/6 mouse small intestinal sucrase/isomaltase using sucrose as substrate after 30 mins |
J Med Chem 60: 9462-9469 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00646 BindingDB Entry DOI: 10.7270/Q2SJ1P1C |
More data for this Ligand-Target Pair | |
Lysosomal acid/Non-lysosomal glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Napoli Federico II
Curated by ChEMBL
| Assay Description Inhibition of [3H]cocaine binding to the dopamine transporter. |
J Med Chem 60: 9462-9469 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00646 BindingDB Entry DOI: 10.7270/Q2SJ1P1C |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM18355
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Napoli Federico II
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GBA1 |
J Med Chem 60: 9462-9469 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00646 BindingDB Entry DOI: 10.7270/Q2SJ1P1C |
More data for this Ligand-Target Pair | 3D Structure (crystal) |