Found 242 hits Enz. Inhib. hit(s) with Target = 'Alpha-mannosidase' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alpha-mannosidase 2
(Drosophila melanogaster (Fruit fly)) | BDBM84868
(Swainsonine derivative, 3)Show SMILES Cc1ccc(cc1)C(=O)C[C@H]1CC[C@@H](O)C2[C@H](O)[C@H](O)CN12 |r| Show InChI InChI=1S/C17H23NO4/c1-10-2-4-11(5-3-10)14(20)8-12-6-7-13(19)16-17(22)15(21)9-18(12)16/h2-5,12-13,15-17,19,21-22H,6-9H2,1H3/t12-,13-,15-,16?,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 2.70 | -48.9 | 29 | n/a | n/a | n/a | n/a | 5.75 | 25 |
University of Toronto
| Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car... |
Chembiochem 11: 673-80 (2010)
Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Drosophila melanogaster (Fruit fly)) | BDBM84869
(Swainsonine derivative, 4)Show SMILES CC(C)(C)c1ccc(cc1)C(=O)C[C@H]1CC[C@@H](O)C2[C@H](O)[C@H](O)CN12 |r| Show InChI InChI=1S/C20H29NO4/c1-20(2,3)13-6-4-12(5-7-13)16(23)10-14-8-9-15(22)18-19(25)17(24)11-21(14)18/h4-7,14-15,17-19,22,24-25H,8-11H2,1-3H3/t14-,15-,17-,18?,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 2.70 | -48.9 | 29 | n/a | n/a | n/a | n/a | 5.75 | 25 |
University of Toronto
| Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car... |
Chembiochem 11: 673-80 (2010)
Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Drosophila melanogaster (Fruit fly)) | BDBM84867
(Swainsonine derivative, 2)Show SMILES O[C@@H]1CN2C([C@@H]1O)[C@H](O)CC[C@@H]2CC(=O)c1ccccc1 |r| Show InChI InChI=1S/C16H21NO4/c18-12-7-6-11(17-9-14(20)16(21)15(12)17)8-13(19)10-4-2-1-3-5-10/h1-5,11-12,14-16,18,20-21H,6-9H2/t11-,12-,14-,15?,16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 2.80 | -48.8 | 30 | n/a | n/a | n/a | n/a | 5.75 | 25 |
University of Toronto
| Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car... |
Chembiochem 11: 673-80 (2010)
Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Drosophila melanogaster (Fruit fly)) | BDBM50168995
((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| 3 | -48.6 | 37 | n/a | n/a | n/a | n/a | 5.75 | 25 |
University of Toronto
| Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car... |
Chembiochem 11: 673-80 (2010)
Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50579647
(CHEMBL5090920)Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCn1cc(COc2ccc(Oc3cc4c5c(cc(Cl)c6c7c(Cl)cc8c9c(cc(Oc%10ccc(OCc%11cn(CCCN%12C[C@H](O)[C@@H](O)[C@H](O)[C@H]%12CO)nn%11)cc%10)c(c3c56)c79)c(=O)n(Cc3cn(CCCN5C[C@H](O)[C@@H](O)[C@H](O)[C@H]5CO)nn3)c8=O)c(=O)n(Cc3cn(CCCN5C[C@H](O)[C@@H](O)[C@H](O)[C@H]5CO)nn3)c4=O)cc2)nn1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Jack bean alpha-mannosidase by Lineweaver-Burk plot |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00036 BindingDB Entry DOI: 10.7270/Q28G8QK8 |
More data for this Ligand-Target Pair | |
alpha-1,2-Mannosidase
(Glycine max) | BDBM50168997
(4-Fluoro-benzoic acid 2-[((2R,3R,4S)-3,4-dihydroxy...)Show SMILES O[C@H]1CN[C@H](CNC(COC(=O)c2ccc(F)cc2)c2ccccc2)[C@H]1O Show InChI InChI=1S/C20H23FN2O4/c21-15-8-6-14(7-9-15)20(26)27-12-17(13-4-2-1-3-5-13)22-10-16-19(25)18(24)11-23-16/h1-9,16-19,22-25H,10-12H2/t16-,17?,18+,19-/m1/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical Sciences and Engineering
Curated by ChEMBL
| Assay Description Binding affinity against alpha-Mannosidase isolated from Jack bean |
J Med Chem 48: 4237-46 (2005)
Article DOI: 10.1021/jm0409019 BindingDB Entry DOI: 10.7270/Q24J0DNV |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50124579
(CHEMBL3621532)Show SMILES OC[C@]12CCC(=O)N1C[C@H](O)[C@@H](O)[C@@H]2O |r| Show InChI InChI=1S/C9H15NO5/c11-4-9-2-1-6(13)10(9)3-5(12)7(14)8(9)15/h5,7-8,11-12,14-15H,1-4H2/t5-,7+,8-,9-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Savitribai Phule Pune University (formerly University of Pune)
Curated by ChEMBL
| Assay Description Inhibition of jack bean alpha-mannosidase using 10 mM p-nitrophenyl-alpha-D-mannopyranoside as substrate |
J Med Chem 58: 7820-32 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00951 BindingDB Entry DOI: 10.7270/Q2G73GKX |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Drosophila melanogaster (Fruit fly)) | BDBM50078117
((1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTAN...)Show SMILES CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O Show InChI InChI=1S/C6H13NO3S/c1-11-6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
| Assay Description The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas... |
Chembiochem 10: 268-77 (2009)
Article DOI: 10.1002/cbic.200800538 BindingDB Entry DOI: 10.7270/Q2DZ06T7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50124578
(CHEMBL3621533)Show SMILES OC[C@@]12CCC(=O)N1C[C@H](O)[C@@H](O)[C@@H]2O |r| Show InChI InChI=1S/C9H15NO5/c11-4-9-2-1-6(13)10(9)3-5(12)7(14)8(9)15/h5,7-8,11-12,14-15H,1-4H2/t5-,7+,8-,9+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Savitribai Phule Pune University (formerly University of Pune)
Curated by ChEMBL
| Assay Description Inhibition of jack bean alpha-mannosidase using 10 mM p-nitrophenyl-alpha-D-mannopyranoside as substrate |
J Med Chem 58: 7820-32 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00951 BindingDB Entry DOI: 10.7270/Q2G73GKX |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84465
(Benzylation of mannostatin A, 1e)Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(Br)cc1 |r| Show InChI InChI=1S/C13H18BrNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 50 | -43.3 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Drosophila melanogaster (Fruit fly)) | BDBM50088625
((1R,2R,3R,4S,5R)-4-Amino-5-methoxy-cyclopentane-1,...)Show SMILES CO[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O Show InChI InChI=1S/C6H13NO4/c1-11-6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
| MMDB PDB Article PubMed
| 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
| Assay Description The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas... |
Chembiochem 10: 268-77 (2009)
Article DOI: 10.1002/cbic.200800538 BindingDB Entry DOI: 10.7270/Q2DZ06T7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50590565
(CHEMBL5199547)Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCn1cc(COc2ccc(Oc3cc4c5c(cc(Oc6ccc(OCc7cn(CCCN8C[C@H](O)[C@@H](O)[C@H](O)[C@H]8CO)nn7)cc6)c6c7c(Oc8ccc(OCc9cn(CCCN%10C[C@H](O)[C@@H](O)[C@H](O)[C@H]%10CO)nn9)cc8)cc8c9c(cc(Oc%10ccc(OCc%11cn(CCCN%12C[C@H](O)[C@@H](O)[C@H](O)[C@H]%12CO)nn%11)cc%10)c(c3c56)c79)c(=O)n(Cc3cn(CCCN5C[C@H](O)[C@@H](O)[C@H](O)[C@H]5CO)nn3)c8=O)c(=O)n(Cc3cn(CCCN5C[C@H](O)[C@@H](O)[C@H](O)[C@H]5CO)nn3)c4=O)cc2)nn1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114621 BindingDB Entry DOI: 10.7270/Q2QN6BSD |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM50078117
((1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTAN...)Show SMILES CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O Show InChI InChI=1S/C6H13NO3S/c1-11-6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 90 | -41.8 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84466
(Benzylation of mannostatin A, 1f)Show SMILES COc1ccc(CN[C@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]2SC)cc1 |r| Show InChI InChI=1S/C14H21NO4S/c1-19-9-5-3-8(4-6-9)7-15-10-11(16)12(17)13(18)14(10)20-2/h3-6,10-18H,7H2,1-2H3/t10-,11+,12+,13+,14+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 100 | -41.6 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84464
(Benzylation of mannostatin A, 1d)Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C13H18ClNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 100 | -41.6 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84462
(Benzylation of mannostatin A, 1b)Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccccc1 |r| Show InChI InChI=1S/C13H19NO3S/c1-18-13-9(10(15)11(16)12(13)17)14-7-8-5-3-2-4-6-8/h2-6,9-17H,7H2,1H3/t9-,10+,11+,12+,13+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| DrugBank Article PubMed
| 110 | -41.3 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50579646
(CHEMBL5078012)Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCn1cc(COc2ccc(Oc3cc4c5c(cc(Oc6ccc(OCc7cn(CCCN8C[C@H](O)[C@@H](O)[C@H](O)[C@H]8CO)nn7)cc6)c6c7c(Cl)cc8c9c(cc(Cl)c(c3c56)c79)c(=O)n(Cc3cn(CCCN5C[C@H](O)[C@@H](O)[C@H](O)[C@H]5CO)nn3)c8=O)c(=O)n(Cc3cn(CCCN5C[C@H](O)[C@@H](O)[C@H](O)[C@H]5CO)nn3)c4=O)cc2)nn1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Jack bean alpha-mannosidase by Lineweaver-Burk plot |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00036 BindingDB Entry DOI: 10.7270/Q28G8QK8 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50590564
(CHEMBL5179216)Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCn1cc(COc2ccc(Oc3cc4c5c(cc(Oc6ccc(OCc7cn(CCCN8C[C@H](O)[C@@H](O)[C@H](O)[C@H]8CO)nn7)cc6)c6c7c(Oc8ccc(OCc9cn(CCCN%10C[C@H](O)[C@@H](O)[C@H](O)[C@H]%10CO)nn9)cc8)cc8c9c(cc(Cl)c(c3c56)c79)c(=O)n(Cc3cn(CCCN5C[C@H](O)[C@@H](O)[C@H](O)[C@H]5CO)nn3)c8=O)c(=O)n(Cc3cn(CCCN5C[C@H](O)[C@@H](O)[C@H](O)[C@H]5CO)nn3)c4=O)cc2)nn1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114621 BindingDB Entry DOI: 10.7270/Q2QN6BSD |
More data for this Ligand-Target Pair | |
alpha-1,2-Mannosidase
(Glycine max) | BDBM50168988
((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)Show SMILES OC[C@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1 |r| Show InChI InChI=1S/C13H20N2O3/c16-8-11(9-4-2-1-3-5-9)14-6-10-13(18)12(17)7-15-10/h1-5,10-18H,6-8H2/t10-,11+,12+,13-/m1/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 135 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical Sciences and Engineering
Curated by ChEMBL
| Assay Description Binding affinity towards alpha-Mannosidase isolated from Jack bean |
J Med Chem 48: 4237-46 (2005)
Article DOI: 10.1021/jm0409019 BindingDB Entry DOI: 10.7270/Q24J0DNV |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84467
(Benzylation of mannostatin A, 1g)Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(cc1)C(=O)OCC=C |r| Show InChI InChI=1S/C17H23NO5S/c1-3-8-23-17(22)11-6-4-10(5-7-11)9-18-12-13(19)14(20)15(21)16(12)24-2/h3-7,12-16,18-21H,1,8-9H2,2H3/t12-,13+,14+,15+,16+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 140 | -40.7 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Drosophila melanogaster (Fruit fly)) | BDBM84614
(Mannostatin B, 2)Show SMILES CS(=O)[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C6H13NO4S/c1-12(11)6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+,12?/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
| Assay Description The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas... |
Chembiochem 10: 268-77 (2009)
Article DOI: 10.1002/cbic.200800538 BindingDB Entry DOI: 10.7270/Q2DZ06T7 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84474
(Aminocyclopentitetrol, 2g)Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(cc2)C(=O)OCC=C)[C@H]1O |r| Show InChI InChI=1S/C16H21NO6/c1-2-7-23-16(22)10-5-3-9(4-6-10)8-17-11-12(18)14(20)15(21)13(11)19/h2-6,11-15,17-21H,1,7-8H2/t11-,12+,13-,14+,15- | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 160 | -40.3 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84463
(Benzylation of mannostatin A, 1c)Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(F)cc1 |r| Show InChI InChI=1S/C13H18FNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 170 | -40.2 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM50078117
((1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTAN...)Show SMILES CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O Show InChI InChI=1S/C6H13NO3S/c1-11-6-2(7)3(8)4(9)5(6)10/h2-6,8-10H,7H2,1H3/t2-,3+,4+,5+,6+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 210 | -39.6 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Drosophila melanogaster (Fruit fly)) | BDBM84615
(Mannostatin analogue, 4a)Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O |r| Show InChI InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2/t1-,2-,3-,4+,5-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
| Assay Description The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas... |
Chembiochem 10: 268-77 (2009)
Article DOI: 10.1002/cbic.200800538 BindingDB Entry DOI: 10.7270/Q2DZ06T7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84472
(Aminocyclopentitetrol, 2e)Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(Br)cc2)[C@H]1O |r| Show InChI InChI=1S/C12H16BrNO4/c13-7-3-1-6(2-4-7)5-14-8-9(15)11(17)12(18)10(8)16/h1-4,8-12,14-18H,5H2/t8-,9+,10-,11+,12- | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 330 | -38.5 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84470
(Aminocyclopentitetrol, 2c)Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(F)cc2)[C@H]1O |r| Show InChI InChI=1S/C12H16FNO4/c13-7-3-1-6(2-4-7)5-14-8-9(15)11(17)12(18)10(8)16/h1-4,8-12,14-18H,5H2/t8-,9+,10-,11+,12- | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 330 | -38.5 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84469
(Aminocyclopentitetrol, 2b)Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccccc2)[C@H]1O |r| Show InChI InChI=1S/C12H17NO4/c14-9-8(10(15)12(17)11(9)16)13-6-7-4-2-1-3-5-7/h1-5,8-17H,6H2/t8-,9+,10-,11+,12- | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 450 | -37.7 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84473
(Aminocyclopentitetrol, 2f)Show SMILES COc1ccc(CN[C@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C13H19NO5/c1-19-8-4-2-7(3-5-8)6-14-9-10(15)12(17)13(18)11(9)16/h2-5,9-18H,6H2,1H3/t9-,10+,11-,12+,13- | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 480 | -37.5 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50525016
(CHEMBL4457217)Show SMILES [H][C@]12COC(=O)N1[C@H](NCCCCCCCCCN=[N+]=[N-])[C@@H](O)[C@@H](O)[C@@H]2O |r,@:6| Show InChI InChI=1S/C16H29N5O5/c17-20-19-9-7-5-3-1-2-4-6-8-18-15-14(24)13(23)12(22)11-10-26-16(25)21(11)15/h11-15,18,22-24H,1-10H2/t11-,12-,13+,14+,15+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sevilla
Curated by ChEMBL
| Assay Description Inhibition of jack bean Lysosomal alpha-mannosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis |
J Med Chem 62: 5832-5843 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00153 BindingDB Entry DOI: 10.7270/Q22R3W4H |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50525015
(CHEMBL4435118)Show SMILES [H][C@]12COC(=O)N1[C@H](NCCCCCCN=[N+]=[N-])[C@@H](O)[C@@H](O)[C@@H]2O |r,@:6| Show InChI InChI=1S/C13H23N5O5/c14-17-16-6-4-2-1-3-5-15-12-11(21)10(20)9(19)8-7-23-13(22)18(8)12/h8-12,15,19-21H,1-7H2/t8-,9-,10+,11+,12+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sevilla
Curated by ChEMBL
| Assay Description Inhibition of jack bean Lysosomal alpha-mannosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis |
J Med Chem 62: 5832-5843 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00153 BindingDB Entry DOI: 10.7270/Q22R3W4H |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50525020
(CHEMBL4518572)Show SMILES [H][C@]12COC(=O)N1[C@H](NCCCCCCCCCNC(=O)OC(C)(C)C)[C@@H](O)[C@@H](O)[C@@H]2O |r,@:6| Show InChI InChI=1S/C21H39N3O7/c1-21(2,3)31-19(28)23-12-10-8-6-4-5-7-9-11-22-18-17(27)16(26)15(25)14-13-30-20(29)24(14)18/h14-18,22,25-27H,4-13H2,1-3H3,(H,23,28)/t14-,15-,16+,17+,18+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sevilla
Curated by ChEMBL
| Assay Description Inhibition of jack bean Lysosomal alpha-mannosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis |
J Med Chem 62: 5832-5843 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00153 BindingDB Entry DOI: 10.7270/Q22R3W4H |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50525014
(CHEMBL4475419)Show SMILES [H][C@]12COC(=O)N1[C@H](NCCCCCCn1cc(CCC)nn1)[C@@H](O)[C@@H](O)[C@@H]2O |r,@:6| Show InChI InChI=1S/C18H31N5O5/c1-2-7-12-10-22(21-20-12)9-6-4-3-5-8-19-17-16(26)15(25)14(24)13-11-28-18(27)23(13)17/h10,13-17,19,24-26H,2-9,11H2,1H3/t13-,14-,15+,16+,17+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sevilla
Curated by ChEMBL
| Assay Description Inhibition of jack bean Lysosomal alpha-mannosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis |
J Med Chem 62: 5832-5843 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00153 BindingDB Entry DOI: 10.7270/Q22R3W4H |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50525017
(CHEMBL4462117)Show SMILES [H][C@]12COC(=O)N1[C@H](NCCCCCCn1cc(COC[C@H]3O[C@@H]4O[C@]5([H])[C@@H](COC)O[C@H](O[C@]6([H])[C@@H](COC)O[C@H](O[C@]7([H])[C@@H](COC)O[C@H](O[C@]8([H])[C@@H](COC)O[C@]([H])(O[C@@H]9[C@@H](COC)O[C@H](O[C@]%10([H])[C@@H](COC)O[C@]([H])(O[C@H]3[C@H](OC)[C@H]4OC)[C@H](OC)[C@H]%10OC)[C@H](OC)[C@H]9OC)[C@H](OC)[C@H]8OC)[C@H](OC)[C@H]7OC)[C@H](OC)[C@H]6OC)[C@H](OC)[C@H]5OC)nn1)[C@@H](O)[C@@H](O)[C@@H]2O |r,@:6| Show InChI InChI=1S/C78H135N5O40/c1-88-30-39-49-56(94-7)64(102-15)72(111-39)119-51-41(32-90-3)113-74(66(104-17)58(51)96-9)121-53-43(34-92-5)115-76(68(106-19)60(53)98-11)123-55-45(36-108-28-37-27-82(81-80-37)26-24-22-21-23-25-79-70-48(86)47(85)46(84)38-29-109-78(87)83(38)70)116-77(69(107-20)62(55)100-13)122-54-44(35-93-6)114-75(67(105-18)61(54)99-12)120-52-42(33-91-4)112-73(65(103-16)59(52)97-10)118-50-40(31-89-2)110-71(117-49)63(101-14)57(50)95-8/h27,38-77,79,84-86H,21-26,28-36H2,1-20H3/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47+,48+,49-,50-,51-,52-,53-,54-,55-,56+,57+,58+,59+,60+,61+,62+,63-,64-,65-,66-,67-,68-,69-,70+,71-,72-,73-,74-,75-,76-,77-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sevilla
Curated by ChEMBL
| Assay Description Inhibition of jack bean Lysosomal alpha-mannosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis |
J Med Chem 62: 5832-5843 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00153 BindingDB Entry DOI: 10.7270/Q22R3W4H |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50525018
(CHEMBL4465842)Show SMILES [H][C@]12COC(=O)N1[C@H](NCCCCCCn1cc(COC[C@H]3O[C@@H]4O[C@]5([H])[C@@H](COCc6cn(CCCCCCN[C@@H]7[C@@H](O)[C@@H](O)[C@H](O)[C@@]8([H])COC(=O)N78)nn6)O[C@H](O[C@]6([H])[C@@H](COCc7cn(CCCCCCN[C@@H]8[C@@H](O)[C@@H](O)[C@H](O)[C@@]9([H])COC(=O)N89)nn7)O[C@H](O[C@]7([H])[C@@H](COCc8cn(CCCCCCN[C@@H]9[C@@H](O)[C@@H](O)[C@H](O)[C@@]%10([H])COC(=O)N9%10)nn8)O[C@H](O[C@]8([H])[C@@H](COCc9cn(CCCCCCN[C@@H]%10[C@@H](O)[C@@H](O)[C@H](O)[C@@]%11([H])COC(=O)N%10%11)nn9)O[C@]([H])(O[C@@H]9[C@@H](COCc%10cn(CCCCCCN[C@@H]%11[C@@H](O)[C@@H](O)[C@H](O)[C@@]%12([H])COC(=O)N%11%12)nn%10)O[C@H](O[C@]%10([H])[C@@H](COCc%11cn(CCCCCCN[C@@H]%12[C@@H](O)[C@@H](O)[C@H](O)[C@@]%13([H])COC(=O)N%12%13)nn%11)O[C@]([H])(O[C@H]3[C@H](OC)[C@H]4OC)[C@H](OC)[C@H]%10OC)[C@H](OC)[C@H]9OC)[C@H](OC)[C@H]8OC)[C@H](OC)[C@H]7OC)[C@H](OC)[C@H]6OC)[C@H](OC)[C@H]5OC)nn1)[C@@H](O)[C@@H](O)[C@@H]2O |r,@:6,54,89,124,159,194,229| Show InChI InChI=1S/C168H273N35O70/c1-232-134-127-99(78-246-64-85-57-190(183-176-85)50-36-22-15-29-43-169-148-120(218)113(211)106(204)92-71-253-162(225)197(92)148)260-155(141(134)239-8)268-128-100(79-247-65-86-58-191(184-177-86)51-37-23-16-30-44-170-149-121(219)114(212)107(205)93-72-254-163(226)198(93)149)262-157(143(241-10)135(128)233-2)270-130-102(81-249-67-88-60-193(186-179-88)53-39-25-18-32-46-172-151-123(221)116(214)109(207)95-74-256-165(228)200(95)151)264-159(145(243-12)137(130)235-4)272-132-104(83-251-69-90-62-195(188-181-90)55-41-27-20-34-48-174-153-125(223)118(216)111(209)97-76-258-167(230)202(97)153)266-161(147(245-14)139(132)237-6)273-133-105(84-252-70-91-63-196(189-182-91)56-42-28-21-35-49-175-154-126(224)119(217)112(210)98-77-259-168(231)203(98)154)265-160(146(244-13)140(133)238-7)271-131-103(82-250-68-89-61-194(187-180-89)54-40-26-19-33-47-173-152-124(222)117(215)110(208)96-75-257-166(229)201(96)152)263-158(144(242-11)138(131)236-5)269-129-101(261-156(267-127)142(240-9)136(129)234-3)80-248-66-87-59-192(185-178-87)52-38-24-17-31-45-171-150-122(220)115(213)108(206)94-73-255-164(227)199(94)150/h57-63,92-161,169-175,204-224H,15-56,64-84H2,1-14H3/t92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113+,114+,115+,116+,117+,118+,119+,120+,121+,122+,123+,124+,125+,126+,127-,128-,129-,130-,131-,132-,133-,134+,135+,136+,137+,138+,139+,140+,141-,142-,143-,144-,145-,146-,147-,148+,149+,150+,151+,152+,153+,154+,155-,156-,157-,158-,159-,160-,161-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sevilla
Curated by ChEMBL
| Assay Description Inhibition of jack bean Lysosomal alpha-mannosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis |
J Med Chem 62: 5832-5843 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00153 BindingDB Entry DOI: 10.7270/Q22R3W4H |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84465
(Benzylation of mannostatin A, 1e)Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(Br)cc1 |r| Show InChI InChI=1S/C13H18BrNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 510 | -37.4 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84466
(Benzylation of mannostatin A, 1f)Show SMILES COc1ccc(CN[C@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]2SC)cc1 |r| Show InChI InChI=1S/C14H21NO4S/c1-19-9-5-3-8(4-6-9)7-15-10-11(16)12(17)13(18)14(10)20-2/h3-6,10-18H,7H2,1-2H3/t10-,11+,12+,13+,14+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 520 | -37.3 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84463
(Benzylation of mannostatin A, 1c)Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(F)cc1 |r| Show InChI InChI=1S/C13H18FNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 530 | -37.3 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84471
(Aminocyclopentitetrol, 2d)Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(Cl)cc2)[C@H]1O |r| Show InChI InChI=1S/C12H16ClNO4/c13-7-3-1-6(2-4-7)5-14-8-9(15)11(17)12(18)10(8)16/h1-4,8-12,14-18H,5H2/t8-,9+,10-,11+,12- | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 670 | -36.7 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84462
(Benzylation of mannostatin A, 1b)Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccccc1 |r| Show InChI InChI=1S/C13H19NO3S/c1-18-13-9(10(15)11(16)12(13)17)14-7-8-5-3-2-4-6-8/h2-6,9-17H,7H2,1H3/t9-,10+,11+,12+,13+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| DrugBank Article PubMed
| 880 | -36.0 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50124580
(CHEMBL3621530)Show SMILES OC[C@@]12CCC(=O)N1C[C@@H](O)[C@@H](O)[C@@H]2O |r| Show InChI InChI=1S/C9H15NO5/c11-4-9-2-1-6(13)10(9)3-5(12)7(14)8(9)15/h5,7-8,11-12,14-15H,1-4H2/t5-,7-,8+,9-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Savitribai Phule Pune University (formerly University of Pune)
Curated by ChEMBL
| Assay Description Inhibition of jack bean alpha-mannosidase using 10 mM p-nitrophenyl-alpha-D-mannopyranoside as substrate |
J Med Chem 58: 7820-32 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00951 BindingDB Entry DOI: 10.7270/Q2G73GKX |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84464
(Benzylation of mannostatin A, 1d)Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C13H18ClNO3S/c1-19-13-9(10(16)11(17)12(13)18)15-6-7-2-4-8(14)5-3-7/h2-5,9-13,15-18H,6H2,1H3/t9-,10+,11+,12+,13+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 910 | -35.9 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
alpha-1,2-Mannosidase
(Glycine max) | BDBM50168999
((2R,3R,4R,5R)-5-(Benzylamino-methyl)-pyrrolidine-2...)Show InChI InChI=1S/C12H18N2O3/c15-10-9(14-12(17)11(10)16)7-13-6-8-4-2-1-3-5-8/h1-5,9-17H,6-7H2/t9-,10-,11-,12-/m1/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical Sciences and Engineering
Curated by ChEMBL
| Assay Description Binding affinity towards alpha-Mannosidase isolated from Jack bean |
J Med Chem 48: 4237-46 (2005)
Article DOI: 10.1021/jm0409019 BindingDB Entry DOI: 10.7270/Q24J0DNV |
More data for this Ligand-Target Pair | |
alpha-1,2-Mannosidase
(Glycine max) | BDBM50168991
((2R,3S,4R,5R)-2-Hydroxymethyl-5-[((R)-2-hydroxy-1-...)Show SMILES OCC(NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O)c1ccccc1 Show InChI InChI=1S/C14H22N2O4/c17-7-11(9-4-2-1-3-5-9)15-6-10-13(19)14(20)12(8-18)16-10/h1-5,10-20H,6-8H2/t10-,11?,12-,13-,14+/m1/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical Sciences and Engineering
Curated by ChEMBL
| Assay Description Binding affinity towards alpha-Mannosidase isolated from Jack bean |
J Med Chem 48: 4237-46 (2005)
Article DOI: 10.1021/jm0409019 BindingDB Entry DOI: 10.7270/Q24J0DNV |
More data for this Ligand-Target Pair | |
alpha-1,2-Mannosidase
(Glycine max) | BDBM50168998
((2R,3R,4S)-2-((R)-Indan-1-ylaminomethyl)-pyrrolidi...)Show InChI InChI=1S/C14H20N2O2/c17-13-8-16-12(14(13)18)7-15-11-6-5-9-3-1-2-4-10(9)11/h1-4,11-18H,5-8H2/t11?,12-,13+,14-/m1/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical Sciences and Engineering
Curated by ChEMBL
| Assay Description Binding affinity towards alpha-Mannosidase isolated from Jack bean |
J Med Chem 48: 4237-46 (2005)
Article DOI: 10.1021/jm0409019 BindingDB Entry DOI: 10.7270/Q24J0DNV |
More data for this Ligand-Target Pair | |
Alpha-mannosidase
(Canavalia ensiformis) | BDBM50525019
(CHEMBL4471561)Show SMILES [H][C@]12COC(=O)N1[C@H](NCCCCCCCC)[C@@H](O)[C@@H](O)[C@@H]2O |r,@:6| Show InChI InChI=1S/C15H28N2O5/c1-2-3-4-5-6-7-8-16-14-13(20)12(19)11(18)10-9-22-15(21)17(10)14/h10-14,16,18-20H,2-9H2,1H3/t10-,11-,12+,13+,14+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Sevilla
Curated by ChEMBL
| Assay Description Inhibition of jack bean Lysosomal alpha-mannosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis |
J Med Chem 62: 5832-5843 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00153 BindingDB Entry DOI: 10.7270/Q22R3W4H |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84467
(Benzylation of mannostatin A, 1g)Show SMILES CS[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H]1NCc1ccc(cc1)C(=O)OCC=C |r| Show InChI InChI=1S/C17H23NO5S/c1-3-8-23-17(22)11-6-4-10(5-7-11)9-18-12-13(19)14(20)15(21)16(12)24-2/h3-7,12-16,18-21H,1,8-9H2,2H3/t12-,13+,14+,15+,16+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 3.22E+3 | -32.6 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM50402966
(CHEMBL2206824)Show SMILES O[C@H]1CN[C@H](CN[C@@H](CNC(=O)c2ccccc2Br)c2ccccc2)[C@H]1O |r| Show InChI InChI=1S/C20H24BrN3O3/c21-15-9-5-4-8-14(15)20(27)24-10-16(13-6-2-1-3-7-13)22-11-17-19(26)18(25)12-23-17/h1-9,16-19,22-23,25-26H,10-12H2,(H,24,27)/t16-,17+,18-,19+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto 687
Curated by ChEMBL
| Assay Description Inhibition of human golgi alpha mannosidase 2 |
Bioorg Med Chem 20: 6945-59 (2012)
Article DOI: 10.1016/j.bmc.2012.10.011 BindingDB Entry DOI: 10.7270/Q26T0NTC |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84474
(Aminocyclopentitetrol, 2g)Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(cc2)C(=O)OCC=C)[C@H]1O |r| Show InChI InChI=1S/C16H21NO6/c1-2-7-23-16(22)10-5-3-9(4-6-10)8-17-11-12(18)14(20)15(21)13(11)19/h2-6,11-15,17-21H,1,7-8H2/t11-,12+,13-,14+,15- | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 4.40E+3 | -31.8 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |
Alpha-mannosidase 2
(Homo sapiens (Human)) | BDBM84470
(Aminocyclopentitetrol, 2c)Show SMILES O[C@H]1[C@@H](O)[C@@H](O)[C@@H](NCc2ccc(F)cc2)[C@H]1O |r| Show InChI InChI=1S/C12H16FNO4/c13-7-3-1-6(2-4-7)5-14-8-9(15)11(17)12(18)10(8)16/h1-4,8-12,14-18H,5H2/t8-,9+,10-,11+,12- | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 6.00E+3 | -31.0 | n/a | n/a | n/a | n/a | n/a | 5.6 | 37 |
University of Georgia
| |
Chembiochem 5: 1220-7 (2004)
Article DOI: 10.1002/cbic.200300842 BindingDB Entry DOI: 10.7270/Q2ZW1JF3 |
More data for this Ligand-Target Pair | |