BDBM20724 (1R,2R)-2-{[4-(4-{[(4-methoxyphenyl)carbamoyl]amino}phenyl)phenyl]carbonyl}cyclopentane-1-carboxylic acid::Urea-based Analogue, 4h
SMILES: COc1ccc(NC(=O)Nc2ccc(cc2)-c2ccc(cc2)C(=O)[C@@H]2CCC[C@H]2C(O)=O)cc1
InChI Key: InChIKey=HVDSJEQDFIMMAI-DNQXCXABSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Diacylglycerol O-acyltransferase 1 (Mus musculus (mouse)) | BDBM20724 ((1R,2R)-2-{[4-(4-{[(4-methoxyphenyl)carbamoyl]amin...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description DGAT-1 activity was characterized by catalyzing the transfer of the radiolabeled decanoyl group onto the syn-3 position of didecanoyl glycerol. The r... | J Med Chem 51: 380-3 (2008) Article DOI: 10.1021/jm7013887 BindingDB Entry DOI: 10.7270/Q2KW5DB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human)) | BDBM20724 ((1R,2R)-2-{[4-(4-{[(4-methoxyphenyl)carbamoyl]amin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description DGAT-1 activity was characterized by catalyzing the transfer of the radiolabeled decanoyl group onto the syn-3 position of didecanoyl glycerol. The r... | J Med Chem 51: 380-3 (2008) Article DOI: 10.1021/jm7013887 BindingDB Entry DOI: 10.7270/Q2KW5DB6 | |||||||||||
More data for this Ligand-Target Pair |