BDBM236485 US9365576, 241

SMILES: COc1ncc(cn1)-c1cc2C(=O)N(C(c2n1C1CC1)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1

InChI Key: InChIKey=XCDMZCXVXUNWIF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 236485   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53-MDM4 (Homo sapiens (Human))	BDBM236485 (US9365576, 241) Show SMILES COc1ncc(cn1)-c1cc2C(=O)N(C(c2n1C1CC1)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1 Show InChI InChI=1S/C27H24ClN5O3/c1-15-10-20(14-31(2)25(15)34)33-23(16-4-6-18(28)7-5-16)24-21(26(33)35)11-22(32(24)19-8-9-19)17-12-29-27(36-3)30-13-17/h4-7,10-14,19,23H,8-9H2,1-3H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair
p53-MDM2 (Homo sapiens (Human))	BDBM236485 (US9365576, 241) Show SMILES COc1ncc(cn1)-c1cc2C(=O)N(C(c2n1C1CC1)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1 Show InChI InChI=1S/C27H24ClN5O3/c1-15-10-20(14-31(2)25(15)34)33-23(16-4-6-18(28)7-5-16)24-21(26(33)35)11-22(32(24)19-8-9-19)17-12-29-27(36-3)30-13-17/h4-7,10-14,19,23H,8-9H2,1-3H3	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.92E+3	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description Assay 1: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou...				US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR
					More data for this Ligand-Target Pair