BDBM24926 1-(3-chlorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::BMCL185648 Compound 15::pyrazolopyridine-based compound, 2
SMILES: C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(Cl)c1)c1ccccc1
InChI Key: InChIKey=NTAIRXFACXVUQO-AWEZNQCLSA-N
Data: 2 IC50
PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human)) | BDBM24926 (1-(3-chlorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 121 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Sunesis Pharmaceuticals | Assay Description An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio... | Bioorg Med Chem Lett 18: 5186-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.091 BindingDB Entry DOI: 10.7270/Q22Z13T8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human)) | BDBM24926 (1-(3-chlorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 121 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Sunesis Pharmaceuticals | Assay Description An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio... | Bioorg Med Chem Lett 18: 5648-52 (2008) Article DOI: 10.1016/j.bmcl.2008.08.095 BindingDB Entry DOI: 10.7270/Q29C6VRP | |||||||||||
More data for this Ligand-Target Pair |