new BindingDB logo
myBDB logout

BDBM285626 3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,2-b]pyridazine-2-carboxamide::US10077269, Example 96::US9598421, Example 96

SMILES: CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F

InChI Key:

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 285626   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))
BDBM285626
PNG
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.58n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM285626
PNG
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 33.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))
BDBM285626
PNG
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 29.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair
Phosphodiesterase 4D


(Homo sapiens (Human))
BDBM285626
PNG
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)|
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 908n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4A (PDE4)


(Homo sapiens (Human))
BDBM285626
PNG
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.58n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4B (PDE4B)


(Homo sapiens (Human))
BDBM285626
PNG
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 33.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
Phosphodiesterase 4C


(Homo sapiens (Human))
BDBM285626
PNG
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)|
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 29.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US9598421 (2017)


BindingDB Entry DOI: 10.7270/Q2K939KG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))
BDBM285626
PNG
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)
Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)|
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 908n/an/an/an/an/an/a



Pfizer Inc.

US Patent




US Patent US10077269 (2018)


BindingDB Entry DOI: 10.7270/Q2P84DX5
More data for this
Ligand-Target Pair