null
SMILES: CN1CCC2(CN(C2)c2cc(ccn2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)CC1
InChI Key: InChIKey=UZWBTUJSENOMKN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human)) | BDBM293479 (US10106527, Compound 93 | US10544128, Compound 93 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | 25 |
Samumed, LLC US Patent | Assay Description Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ... | US Patent US10106527 (2018) BindingDB Entry DOI: 10.7270/Q2PN97Q3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM293479 (US10106527, Compound 93 | US10544128, Compound 93 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 6.27E+3 | n/a | n/a | n/a | 25 |
Samumed, LLC US Patent | Assay Description Briefly, recombinant GSK3β kinase, ATP and Ser/Thr peptide 09 are prepared in 1× Kinase buffer to final concentrations of 0.04 μg/mL, 46 ... | US Patent US10106527 (2018) BindingDB Entry DOI: 10.7270/Q2PN97Q3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM293479 (US10106527, Compound 93 | US10544128, Compound 93 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 6.27E+3 | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA | Assay Description The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div... | Bioorg Med Chem Lett 17: 4442-6 (2007) BindingDB Entry DOI: 10.7270/Q2862JRD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM293479 (US10106527, Compound 93 | US10544128, Compound 93 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 6.27E+3 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di... | US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene Wnt-1 (Homo sapiens (human)) | BDBM293479 (US10106527, Compound 93 | US10544128, Compound 93 ...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 36 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col... | US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human)) | BDBM293479 (US10106527, Compound 93 | US10544128, Compound 93 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis... | US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human)) | BDBM293479 (US10106527, Compound 93 | US10544128, Compound 93 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
Tanabe Research Laboratories USA | Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis... | Bioorg Med Chem Lett 17: 4442-6 (2007) BindingDB Entry DOI: 10.7270/Q2862JRD | |||||||||||
More data for this Ligand-Target Pair |