BDBM31886 CD564::CHEMBL309282
SMILES: CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)c1ccc2cc(ccc2c1)C(O)=O
InChI Key: InChIKey=RWYREGSYPCNZTL-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoic Acid Receptor, gamma (Homo sapiens (Human)) | BDBM31886 (CD564 | CHEMBL309282) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | n/a | 3 | n/a | n/a | n/a | 7.9 | 4 |
CNRS | Assay Description Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch... | J Mol Biol 302: 155-70 (2000) Article DOI: 10.1006/jmbi.2000.4032 BindingDB Entry DOI: 10.7270/Q2BR8QHR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Retinoic Acid Receptor, alpha (Homo sapiens (Human)) | BDBM31886 (CD564 | CHEMBL309282) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 118 | n/a | n/a | n/a | 7.9 | 4 |
CNRS | Assay Description Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch... | J Mol Biol 302: 155-70 (2000) Article DOI: 10.1006/jmbi.2000.4032 BindingDB Entry DOI: 10.7270/Q2BR8QHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic Acid Receptor, beta (Homo sapiens (Human)) | BDBM31886 (CD564 | CHEMBL309282) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | 7.9 | 4 |
CNRS | Assay Description Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch... | J Mol Biol 302: 155-70 (2000) Article DOI: 10.1006/jmbi.2000.4032 BindingDB Entry DOI: 10.7270/Q2BR8QHR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cytochrome P450 26B1 (Homo sapiens (Human)) | BDBM31886 (CD564 | CHEMBL309282) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Montana Curated by ChEMBL | Assay Description Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit... | J Med Chem 59: 2579-95 (2016) BindingDB Entry DOI: 10.7270/Q2J38VG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM31886 (CD564 | CHEMBL309282) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assay | J Med Chem 39: 2411-21 (1996) Article DOI: 10.1021/jm9502293 BindingDB Entry DOI: 10.7270/Q2MS3RVK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM31886 (CD564 | CHEMBL309282) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assay | J Med Chem 39: 2411-21 (1996) Article DOI: 10.1021/jm9502293 BindingDB Entry DOI: 10.7270/Q2MS3RVK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cytochrome CYP26A1 (Homo sapiens (Human)) | BDBM31886 (CD564 | CHEMBL309282) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Montana Curated by ChEMBL | Assay Description Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addit... | J Med Chem 59: 2579-95 (2016) BindingDB Entry DOI: 10.7270/Q2J38VG8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human)) | BDBM31886 (CD564 | CHEMBL309282) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 118 | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Apparent binding constant against Retinoic acid receptor alpha in HeLa cell GAl-4 transactivation assay | J Med Chem 39: 2411-21 (1996) Article DOI: 10.1021/jm9502293 BindingDB Entry DOI: 10.7270/Q2MS3RVK | |||||||||||
More data for this Ligand-Target Pair |