BDBM342346 6-(6-methoxy-3-pyridyl)-4-[4-methyl-4- [4-methyl-5-[4-(trifluoromethyl)phenyl]- 1H-imidazol-2-yl]-1-piperidyl]-7H- pyrrolo[2,3-d]pyrimidine::US9771369, Compound P-3178
SMILES: COc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(C)(CC1)c1nc(C)c([nH]1)-c1ccc(cc1)C(F)(F)F
InChI Key: InChIKey=CBLSRVMYOQYNCK-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase Kit (Kit)(D816V) (Homo sapiens (Human)) | BDBM342346 (6-(6-methoxy-3-pyridyl)-4-[4-methyl-4- [4-methyl-5...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon Inc. US Patent | Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ... | US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM342346 (6-(6-methoxy-3-pyridyl)-4-[4-methyl-4- [4-methyl-5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon Inc. US Patent | Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,... | US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q | |||||||||||
More data for this Ligand-Target Pair |