BDBM345268 2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxyphenyl)pyrazol-3-yl]methoxy]-2- methyl-propanoic acid 1H NMR (CDCl3, 400 MHz) $#948; 1.58 (s, 6H), 3.68 (s, 3H), 4.62 (s, 2H), 5.46 (s, 2H), 6.42 (s, 1H), 6.74-6.81 (m, 2H), 6.82- 6.88 (m, 1H), 6.89-6.94 (m, 1H), 7.15- 7023 (m, 2H), 7.26-7.37 (m, 2H).::US10202350, Example 14::US10214492, Example 14
SMILES: COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl
InChI Key: InChIKey=XWCDPGKAMJDMKE-UHFFFAOYSA-N
Data: 10 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Monocarboxylate transporter 4 (Homo sapiens (Human)) | BDBM345268 (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t... | US Patent US10202350 (2019) BindingDB Entry DOI: 10.7270/Q20K2BPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 4 (Homo sapiens (Human)) | BDBM345268 (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known... | US Patent US10202350 (2019) BindingDB Entry DOI: 10.7270/Q20K2BPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Malignant T-cell-amplified sequence 1 (Homo sapiens (human)) | BDBM345268 (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those... | US Patent US10202350 (2019) BindingDB Entry DOI: 10.7270/Q20K2BPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 4 (Homo sapiens (Human)) | BDBM345268 (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ... | US Patent US10202350 (2019) BindingDB Entry DOI: 10.7270/Q20K2BPB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 1 (Homo sapiens (Human)) | BDBM345268 (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those... | US Patent US10214492 (2019) BindingDB Entry DOI: 10.7270/Q2Q81GC0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 4 (Homo sapiens (Human)) | BDBM345268 (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MCT4 may be stably expressed in MDA-MB-453 breast cancer cells that do not express native MCT1 or MCT4. MCT4 activity may be assessed by monitoring t... | US Patent US10214492 (2019) BindingDB Entry DOI: 10.7270/Q2Q81GC0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 4 (Homo sapiens (Human)) | BDBM345268 (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description NCI-H358 lung adenocarcinoma cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known... | US Patent US10214492 (2019) BindingDB Entry DOI: 10.7270/Q2Q81GC0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 1 (Homo sapiens (Human)) | BDBM345268 (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those... | US Patent US10214492 (2019) BindingDB Entry DOI: 10.7270/Q2Q81GC0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 4 (Homo sapiens (Human)) | BDBM345268 (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ... | US Patent US10214492 (2019) BindingDB Entry DOI: 10.7270/Q2Q81GC0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Malignant T-cell-amplified sequence 1 (Homo sapiens (human)) | BDBM345268 (2-[[1-[(2-Chlorophenyl)methyl]-5-(3- methoxypheny...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC US Patent | Assay Description MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those... | US Patent US10202350 (2019) BindingDB Entry DOI: 10.7270/Q20K2BPB | |||||||||||
More data for this Ligand-Target Pair |