BDBM37633 (2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic acid::(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid::(2S)-2-azanyl-3-(3-iodanyl-4-oxidanyl-phenyl)propanoic acid::3-IODO-L-TYROSINE::3-Iodo-L-tyrosine (I-Tyr)::MLS000069664::Monoiodotyrosine::SMR000059143::cid_439744
SMILES: N[C@@H](Cc1ccc(O)c(I)c1)C(O)=O
InChI Key: InChIKey=UQTZMGFTRHFAAM-ZETCQYMHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N-formyl peptide receptor 2 (Homo sapiens (Human)) | BDBM37633 ((2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic ...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | >4.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NMMLSC Curated by PubChem BioAssay | Assay Description University of New Mexico Assay Overview Assay Support: NIH 1R03MH076381-01 Assay for Formylpeptide Receptor Family Ligands PI: Bruce S. Edwards, Ph.... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2DF6PMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
fMet-Leu-Phe receptor (Homo sapiens (Human)) | BDBM37633 ((2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | >4.37E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NMMLSC Curated by PubChem BioAssay | Assay Description University of New Mexico Assay Overview: Assay Support: NIH 1R03MH076381-01 Assay for Formylpeptide Receptor Family Ligands PI: Bruce S. Edwards, Ph... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2NZ862K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Iodotyrosine deiodinase (IYD) (Homo sapiens (Human)) | BDBM37633 ((2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic ...) | PDB GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University | Assay Description Dissociation constants (Kd) for the ligands of IYD were determined by their ability to quench the fluorescence of the oxidized FMN (FMNox) (λex ... | Biochemistry 56: 1130-1139 (2017) Article DOI: 10.1021/acs.biochem.6b01308 BindingDB Entry DOI: 10.7270/Q2ZK5FJM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Iodotyrosine deiodinase (IYD) (Haliscomenobacter hydrossis) | BDBM37633 ((2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic ...) | PDB GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University | Assay Description Dissociation constants (Kd) for the ligands of IYD were determined by their ability to quench the fluorescence of the oxidized FMN (FMNox) (λex ... | Biochemistry 56: 1130-1139 (2017) Article DOI: 10.1021/acs.biochem.6b01308 BindingDB Entry DOI: 10.7270/Q2ZK5FJM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine 3-hydroxylase (Rattus norvegicus) | BDBM37633 ((2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of rat tyrosine hydroxylase | Bioorg Med Chem 18: 7675-99 (2010) Article DOI: 10.1016/j.bmc.2010.07.034 BindingDB Entry DOI: 10.7270/Q2DF6S69 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
N-formyl peptide receptor 2 (Homo sapiens (Human)) | BDBM37633 ((2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic ...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | >6.67E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NMMLSC Curated by PubChem BioAssay | Assay Description University of New Mexico Assay Overview Assay Support: NIH 1R03MH076381-01 Assay for Formylpeptide Receptor Family Ligands PI: Bruce S. Edwards, Ph.... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2DF6PMF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
fMet-Leu-Phe receptor (Homo sapiens (Human)) | BDBM37633 ((2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | >6.67E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NMMLSC Curated by PubChem BioAssay | Assay Description University of New Mexico Assay Overview: Assay Support: NIH 1R03MH076381-01 Assay for Formylpeptide Receptor Family Ligands PI: Bruce S. Edwards, Ph... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2J67FB5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein (West Nile virus) | BDBM37633 ((2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay | Assay Description The HTS assay to identify Inhibitors of West Nile Virus (WNV) NS2bNS3 Proteinase was proposed by Dr Alex Strongin of the Burnham Institute XO1-MH0776... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2222S6W | |||||||||||
More data for this Ligand-Target Pair |