BDBM397846 US9994552, Compound 57

SMILES: COc1cccc(Cc2cnc(nc2)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)c1

InChI Key: InChIKey=SKYTUAHNZJSBPF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 397846   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Kit (Kit)(D816V) (Homo sapiens (Human))	BDBM397846 (US9994552, Compound 57) Show SMILES COc1cccc(Cc2cnc(nc2)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)c1 Show InChI InChI=1S/C26H28N6O3/c1-33-20-6-4-5-18(12-20)11-19-15-27-26(28-16-19)32-9-7-31(8-10-32)25-21-13-23(34-2)24(35-3)14-22(21)29-17-30-25/h4-6,12-17H,7-11H2,1-3H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM397846 (US9994552, Compound 57) Show SMILES COc1cccc(Cc2cnc(nc2)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)c1 Show InChI InChI=1S/C26H28N6O3/c1-33-20-6-4-5-18(12-20)11-19-15-27-26(28-16-19)32-9-7-31(8-10-32)25-21-13-23(34-2)24(35-3)14-22(21)29-17-30-25/h4-6,12-17H,7-11H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair