BDBM445218 US10669235, Example 9

SMILES: COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C

InChI Key: InChIKey=UDIUFPPEHOBBAN-DQSJHHFOSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 445218   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.89	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
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VHL/PDGFRB (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		7.89	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.36	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		8.36	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		9.42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		17.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	17.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	38.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		38.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	133	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) (Homo sapiens (Human))	BDBM445218 (US10669235, Example 9 | US11208381, Example 9) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		133	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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