BDBM50005856 1-(4-Dimethylamino-but-2-ynyl)-pyrrolidin-2-one::CHEMBL41779

SMILES: CN(C)CC#CCN1CCCC1=O

InChI Key: InChIKey=VFCXPAQOWQSKLL-UHFFFAOYSA-N

Data: 9 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50005856   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor (RAT)	BDBM50005856 (1-(4-Dimethylamino-but-2-ynyl)-pyrrolidin-2-one | ...) Show SMILES CN(C)CC#CCN1CCCC1=O Show InChI InChI=1S/C10H16N2O/c1-11(2)7-3-4-8-12-9-5-6-10(12)13/h5-9H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]OXO-M radioligand (in vitro)				J Med Chem 34: 2314-27 (1991) BindingDB Entry DOI: 10.7270/Q2057J5V
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50005856 (1-(4-Dimethylamino-but-2-ynyl)-pyrrolidin-2-one | ...) Show SMILES CN(C)CC#CCN1CCCC1=O Show InChI InChI=1S/C10H16N2O/c1-11(2)7-3-4-8-12-9-5-6-10(12)13/h5-9H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical Research Division of American Cyanamid Company Curated by ChEMBL					Assay Description Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.				J Med Chem 36: 3533-41 (1994) BindingDB Entry DOI: 10.7270/Q28916GB
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50005856 (1-(4-Dimethylamino-but-2-ynyl)-pyrrolidin-2-one | ...) Show SMILES CN(C)CC#CCN1CCCC1=O Show InChI InChI=1S/C10H16N2O/c1-11(2)7-3-4-8-12-9-5-6-10(12)13/h5-9H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical Research Division of American Cyanamid Company Curated by ChEMBL					Assay Description Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.				J Med Chem 36: 3533-41 (1994) BindingDB Entry DOI: 10.7270/Q28916GB
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50005856 (1-(4-Dimethylamino-but-2-ynyl)-pyrrolidin-2-one | ...) Show SMILES CN(C)CC#CCN1CCCC1=O Show InChI InChI=1S/C10H16N2O/c1-11(2)7-3-4-8-12-9-5-6-10(12)13/h5-9H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	926	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstem				J Med Chem 35: 1550-7 (1992) BindingDB Entry DOI: 10.7270/Q2MK6BT7
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50005856 (1-(4-Dimethylamino-but-2-ynyl)-pyrrolidin-2-one | ...) Show SMILES CN(C)CC#CCN1CCCC1=O Show InChI InChI=1S/C10H16N2O/c1-11(2)7-3-4-8-12-9-5-6-10(12)13/h5-9H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical Research Division of American Cyanamid Company Curated by ChEMBL					Assay Description Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.				J Med Chem 36: 3533-41 (1994) BindingDB Entry DOI: 10.7270/Q28916GB
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor (RAT)	BDBM50005856 (1-(4-Dimethylamino-but-2-ynyl)-pyrrolidin-2-one | ...) Show SMILES CN(C)CC#CCN1CCCC1=O Show InChI InChI=1S/C10H16N2O/c1-11(2)7-3-4-8-12-9-5-6-10(12)13/h5-9H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Upjohn Company Curated by ChEMBL					Assay Description Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]QNB radioligand (in vitro)				J Med Chem 34: 2314-27 (1991) BindingDB Entry DOI: 10.7270/Q2057J5V
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50005856 (1-(4-Dimethylamino-but-2-ynyl)-pyrrolidin-2-one | ...) Show SMILES CN(C)CC#CCN1CCCC1=O Show InChI InChI=1S/C10H16N2O/c1-11(2)7-3-4-8-12-9-5-6-10(12)13/h5-9H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical Research Division of American Cyanamid Company Curated by ChEMBL					Assay Description Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.				J Med Chem 36: 3533-41 (1994) BindingDB Entry DOI: 10.7270/Q28916GB
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50005856 (1-(4-Dimethylamino-but-2-ynyl)-pyrrolidin-2-one | ...) Show SMILES CN(C)CC#CCN1CCCC1=O Show InChI InChI=1S/C10H16N2O/c1-11(2)7-3-4-8-12-9-5-6-10(12)13/h5-9H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical Research Division of American Cyanamid Company Curated by ChEMBL					Assay Description Binding affinity at [3H]PZ radiolabeled muscarinic M1 receptor in rat cortex.				J Med Chem 36: 3533-41 (1994) BindingDB Entry DOI: 10.7270/Q28916GB
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50005856 (1-(4-Dimethylamino-but-2-ynyl)-pyrrolidin-2-one | ...) Show SMILES CN(C)CC#CCN1CCCC1=O Show InChI InChI=1S/C10H16N2O/c1-11(2)7-3-4-8-12-9-5-6-10(12)13/h5-9H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.59E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M1 in rat cortex				J Med Chem 35: 1550-7 (1992) BindingDB Entry DOI: 10.7270/Q2MK6BT7
					More data for this Ligand-Target Pair