BDBM50010874 1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclohexanol::1-[1-(4-Chloro-phenyl)-2-dimethylamino-ethyl]-cyclohexanol (HCl)::CHEMBL420644
SMILES: CN(C)CC(c1ccc(Cl)cc1)C1(O)CCCCC1
InChI Key: InChIKey=HQVQWOHDTVRIMI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50010874 (1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 249 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells | J Med Chem 51: 4038-49 (2008) Article DOI: 10.1021/jm8002262 BindingDB Entry DOI: 10.7270/Q2TB16PB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50010874 (1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of 5HT uptake at human SERT expressed in human JAR cells | J Med Chem 51: 4038-49 (2008) Article DOI: 10.1021/jm8002262 BindingDB Entry DOI: 10.7270/Q2TB16PB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Norepinephrine Monoamine transporters (Rattus norvegicus) | BDBM50010874 (1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes | J Med Chem 33: 2899-905 (1990) BindingDB Entry DOI: 10.7270/Q20C4WCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transporter (Rattus norvegicus (rat)) | BDBM50010874 (1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...) | Reactome pathway UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of norepinephrine uptake at rat brain norepinephrine transporter | J Med Chem 51: 4038-49 (2008) Article DOI: 10.1021/jm8002262 BindingDB Entry DOI: 10.7270/Q2TB16PB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50010874 (1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain | J Med Chem 33: 2899-905 (1990) BindingDB Entry DOI: 10.7270/Q20C4WCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50010874 (1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Curated by ChEMBL | Assay Description Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes | J Med Chem 33: 2899-905 (1990) BindingDB Entry DOI: 10.7270/Q20C4WCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50010874 (1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of norepinephrine uptake at human norepinephrine transporter expressed in MDCK-Net6 cells | J Med Chem 51: 4038-49 (2008) Article DOI: 10.1021/jm8002262 BindingDB Entry DOI: 10.7270/Q2TB16PB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50010874 (1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of 5HT uptake at rat brain SERT | J Med Chem 51: 4038-49 (2008) Article DOI: 10.1021/jm8002262 BindingDB Entry DOI: 10.7270/Q2TB16PB | |||||||||||
More data for this Ligand-Target Pair |