BDBM50036760 6-chloro-1'-phenethylspiro[1,2,3,4-tetrahydronaphthalene-2,4'-(hexahydropyridine)]-1-one::CHEMBL122761

SMILES: Clc1ccc2C(=O)C3(CCN(CCc4ccccc4)CC3)CCc2c1

InChI Key: InChIKey=IWOPGTFNUXEULQ-UHFFFAOYSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50036760   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50036760 (6-chloro-1'-phenethylspiro[1,2,3,4-tetrahydronapht...) Show SMILES Clc1ccc2C(=O)C3(CCN(CCc4ccccc4)CC3)CCc2c1 Show InChI InChI=1S/C22H24ClNO/c23-19-6-7-20-18(16-19)8-10-22(21(20)25)11-14-24(15-12-22)13-9-17-4-2-1-3-5-17/h1-7,16H,8-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Curated by ChEMBL					Assay Description Binding affinity for displacement of [3H]ketanserin to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cells				J Med Chem 45: 492-503 (2002) BindingDB Entry DOI: 10.7270/Q2KH0P27
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50036760 (6-chloro-1'-phenethylspiro[1,2,3,4-tetrahydronapht...) Show SMILES Clc1ccc2C(=O)C3(CCN(CCc4ccccc4)CC3)CCc2c1 Show InChI InChI=1S/C22H24ClNO/c23-19-6-7-20-18(16-19)8-10-22(21(20)25)11-14-24(15-12-22)13-9-17-4-2-1-3-5-17/h1-7,16H,8-15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Curated by ChEMBL					Assay Description Binding affinity for displacement of [3H]ketanserin to rat 5-hydroxytryptamine 2A receptor stably expressed in CHO cells				J Med Chem 45: 492-503 (2002) BindingDB Entry DOI: 10.7270/Q2KH0P27
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50036760 (6-chloro-1'-phenethylspiro[1,2,3,4-tetrahydronapht...) Show SMILES Clc1ccc2C(=O)C3(CCN(CCc4ccccc4)CC3)CCc2c1 Show InChI InChI=1S/C22H24ClNO/c23-19-6-7-20-18(16-19)8-10-22(21(20)25)11-14-24(15-12-22)13-9-17-4-2-1-3-5-17/h1-7,16H,8-15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Binding affinity for sigma receptor of guinea pig whole brain using [3H]-SKF- 100047 radioligand				J Med Chem 37: 364-70 (1994) BindingDB Entry DOI: 10.7270/Q2WD416F
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50036760 (6-chloro-1'-phenethylspiro[1,2,3,4-tetrahydronapht...) Show SMILES Clc1ccc2C(=O)C3(CCN(CCc4ccccc4)CC3)CCc2c1 Show InChI InChI=1S/C22H24ClNO/c23-19-6-7-20-18(16-19)8-10-22(21(20)25)11-14-24(15-12-22)13-9-17-4-2-1-3-5-17/h1-7,16H,8-15H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	850	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Curated by ChEMBL					Assay Description Binding affinity for displacement of [3H]mesulergine to human 5-hydroxytryptamine 2C receptor stably expressed in CHO cells				J Med Chem 45: 492-503 (2002) BindingDB Entry DOI: 10.7270/Q2KH0P27
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50036760 (6-chloro-1'-phenethylspiro[1,2,3,4-tetrahydronapht...) Show SMILES Clc1ccc2C(=O)C3(CCN(CCc4ccccc4)CC3)CCc2c1 Show InChI InChI=1S/C22H24ClNO/c23-19-6-7-20-18(16-19)8-10-22(21(20)25)11-14-24(15-12-22)13-9-17-4-2-1-3-5-17/h1-7,16H,8-15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Curated by ChEMBL					Assay Description Binding affinity for displacement of [3H]spiperone to human dopamine D2 (hD2) receptors stably expressed in CHO cells				J Med Chem 45: 492-503 (2002) BindingDB Entry DOI: 10.7270/Q2KH0P27
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50036760 (6-chloro-1'-phenethylspiro[1,2,3,4-tetrahydronapht...) Show SMILES Clc1ccc2C(=O)C3(CCN(CCc4ccccc4)CC3)CCc2c1 Show InChI InChI=1S/C22H24ClNO/c23-19-6-7-20-18(16-19)8-10-22(21(20)25)11-14-24(15-12-22)13-9-17-4-2-1-3-5-17/h1-7,16H,8-15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Binding affinity for dopamine D2 receptor using [3H]spiperone in guinea pig striatum				J Med Chem 37: 364-70 (1994) BindingDB Entry DOI: 10.7270/Q2WD416F
					More data for this Ligand-Target Pair