BDBM50046145 2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4-oxazinan-4-ium-2-yl]acetate(hemipalmitoylcarnitinium (HPC))::Acylcarnitine analogue::CHEMBL48257::Hemiacylcarnitinium(+)-HPC
SMILES: CCCCCCCCCCCCCCC[C@@]1(O)C[N+](C)(C)C[C@@H](CC([O-])=O)O1
InChI Key: InChIKey=SPDGRWIGMIHIAC-GGAORHGYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Carnitine palmitoyltransferase 2 (Homo sapiens (Human)) | BDBM50046145 (2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Competitive inhibition of CPT2 | J Med Chem 54: 3109-52 (2011) Article DOI: 10.1021/jm100809g BindingDB Entry DOI: 10.7270/Q29K4CDQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carnitine palmitoyltransferase 2 (Homo sapiens (Human)) | BDBM50046145 (2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Competitive inhibition of CPT2 in heart mitochondria using carnitine | J Med Chem 54: 3109-52 (2011) Article DOI: 10.1021/jm100809g BindingDB Entry DOI: 10.7270/Q29K4CDQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carnitine palmitoyltransferase 1B (Rattus norvegicus) | BDBM50046145 (2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...) | Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Louisiana State University Curated by ChEMBL | Assay Description Compound was evaluated for its ability to inhibit carnitine palmitoyltransferase I activity in intact mitochondria from rat heart | J Med Chem 36: 237-42 (1993) BindingDB Entry DOI: 10.7270/Q2P849ZC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carnitine palmitoyltransferase 2 (Homo sapiens (Human)) | BDBM50046145 (2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Competitive inhibition of CPT2 in liver mitochondria using carnitine | J Med Chem 54: 3109-52 (2011) Article DOI: 10.1021/jm100809g BindingDB Entry DOI: 10.7270/Q29K4CDQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carnitine palmitoyltransferase 1A (Rattus norvegicus) | BDBM50046145 (2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Louisiana State University Curated by ChEMBL | Assay Description Compound was evaluated for its ability to inhibit carnitine palmitoyltransferase I activity in intact mitochondria from rat liver | J Med Chem 36: 237-42 (1993) BindingDB Entry DOI: 10.7270/Q2P849ZC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carnitine palmitoyltransferase 1A (Rattus norvegicus) | BDBM50046145 (2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Inhibition of rat CPT1A using [3H]carnitine by radiometric assay | J Med Chem 54: 3109-52 (2011) Article DOI: 10.1021/jm100809g BindingDB Entry DOI: 10.7270/Q29K4CDQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carnitine palmitoyltransferase 2 (Rattus norvegicus) | BDBM50046145 (2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Inhibition of rat CPT2 using [3H]carnitine by radiometric assay | J Med Chem 54: 3109-52 (2011) Article DOI: 10.1021/jm100809g BindingDB Entry DOI: 10.7270/Q29K4CDQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carnitine palmitoyltransferase 1A (Rattus norvegicus) | BDBM50046145 (2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Inhibition of rat CPT1A using [3H]carnitine by radiometric assay | J Med Chem 54: 3109-52 (2011) Article DOI: 10.1021/jm100809g BindingDB Entry DOI: 10.7270/Q29K4CDQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C (PKC) (Rattus norvegicus) | BDBM50046145 (2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 4.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Louisiana State University Curated by ChEMBL | Assay Description Inhibition of protein kinase C (PKC) purified from rat brain | J Med Chem 36: 177-8 (1993) BindingDB Entry DOI: 10.7270/Q2Z321VQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carnitine palmitoyltransferase 2 (Rattus norvegicus) | BDBM50046145 (2-[6-hydroxy-4,4-dimethyl-6-pentadecyl-(2R,6S)-1,4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Inhibition of rat CPT2 using [3H]carnitine by radiometric assay | J Med Chem 54: 3109-52 (2011) Article DOI: 10.1021/jm100809g BindingDB Entry DOI: 10.7270/Q29K4CDQ | |||||||||||
More data for this Ligand-Target Pair |