BDBM50074569 (6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-methyl-ammonio}-hexyl)-dimethyl-ammonium Dibromide::Bis (ammonio) alkane analogue::Bis-{3-(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)propyl(trimethyl)ammonium}butane; dibromide::CHEMBL266295::N1,N6-bis(3-(1,3-dioxoisoindolin-2-yl)propyl)-N1,N1,N6,N6-tetramethylhexane-1,6-diaminium bromide
SMILES: C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O
InChI Key: InChIKey=WDAXQFXYXWPELC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human)) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs | J Med Chem 60: 3314-3334 (2017) Article DOI: 10.1021/acs.jmedchem.6b01892 BindingDB Entry DOI: 10.7270/Q29S1THC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human)) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs | J Med Chem 60: 3314-3334 (2017) Article DOI: 10.1021/acs.jmedchem.6b01892 BindingDB Entry DOI: 10.7270/Q29S1THC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human)) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting ... | J Med Chem 60: 3314-3334 (2017) Article DOI: 10.1021/acs.jmedchem.6b01892 BindingDB Entry DOI: 10.7270/Q29S1THC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human)) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 407 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)pipe... | J Med Chem 63: 4133-4154 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human)) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 646 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)p... | J Med Chem 63: 4133-4154 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human)) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 851 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4... | J Med Chem 63: 4133-4154 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human)) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation c... | J Med Chem 60: 3314-3334 (2017) Article DOI: 10.1021/acs.jmedchem.6b01892 BindingDB Entry DOI: 10.7270/Q29S1THC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human)) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)pipe... | J Med Chem 63: 4133-4154 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human)) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pE... | J Med Chem 45: 3809-12 (2002) Article DOI: 10.1021/jm020871e BindingDB Entry DOI: 10.7270/Q2V127K0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholinergic, muscarinic (GUINEA PIG) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 1.41E+3 | n/a | n/a | n/a | n/a |
University of W�rzburg Curated by ChEMBL | Assay Description Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors | J Med Chem 43: 2155-64 (2000) BindingDB Entry DOI: 10.7270/Q2S183QS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 (GUINEA PIG) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a |
University of W£rzburg Curated by ChEMBL | Assay Description Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2. | J Med Chem 46: 1031-40 (2003) Article DOI: 10.1021/jm021017q BindingDB Entry DOI: 10.7270/Q2ST7SJC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 and M5 (Homo sapiens (Human)) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 479 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay | J Med Chem 60: 3314-3334 (2017) Article DOI: 10.1021/acs.jmedchem.6b01892 BindingDB Entry DOI: 10.7270/Q29S1THC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholinergic, muscarinic (GUINEA PIG) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.44E+3 | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Allosteric potency against the dissociation of radioligand [3H]-N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2 | J Med Chem 42: 849-58 (1999) Article DOI: 10.1021/jm981023f BindingDB Entry DOI: 10.7270/Q22806RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M2 (GUINEA PIG) | BDBM50074569 ((6-{bis[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pr...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.44E+3 | n/a | n/a | n/a | n/a |
University of Wuerzburg Curated by ChEMBL | Assay Description Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart | J Med Chem 46: 1390-407 (2003) Article DOI: 10.1021/jm021077w BindingDB Entry DOI: 10.7270/Q2JD50JS | |||||||||||
More data for this Ligand-Target Pair |