BDBM50081702 5-Methoxy-3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indole::CHEMBL133939
SMILES: COc1ccc2[nH]cc(C[C@@H]3CCCN3C)c2c1
InChI Key: InChIKey=MKEGUJPBCIXABO-LBPRGKRZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50081702 (5-Methoxy-3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Compound was tested for binding affinity using [3H]-MDL-100,907 at 5-hydroxytryptamine 2A receptor sites in rat cortical homogenate. | J Med Chem 42: 4257-63 (1999) BindingDB Entry DOI: 10.7270/Q2FX78PW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat)) | BDBM50081702 (5-Methoxy-3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer, Inc Curated by ChEMBL | Assay Description Binding affinity of the compound against 5-hydroxytryptamine 1C receptor | J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50081702 (5-Methoxy-3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer, Inc Curated by ChEMBL | Assay Description Binding affinity of the compound against 5-hydroxytryptamine 1A receptor | J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50081702 (5-Methoxy-3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer, Inc Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 2 receptor using [125I]DOI as radioligand. | J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 1d (5-HT1d) receptor (GUINEA PIG) | BDBM50081702 (5-Methoxy-3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer, Inc Curated by ChEMBL | Assay Description Binding affinity of the compound against 5-hydroxytryptamine 1D receptor | J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50081702 (5-Methoxy-3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer, Inc Curated by ChEMBL | Assay Description Effect of the compound on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra. | J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1B (Homo sapiens (Human)) | BDBM50081702 (5-Methoxy-3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer, Inc Curated by ChEMBL | Assay Description Binding affinity of the compound against 5-hydroxytryptamine 1B receptor | J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5 | |||||||||||
More data for this Ligand-Target Pair |