BindingDB PrimarySearch

BDBM50099066 CHEMBL279115::phorbol 13-acetate 12-myristate

SMILES: CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O

InChI Key: InChIKey=PHEDXBVPIONUQT-CMMOZPOHSA-N

Data: 6 KI 8 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50099066
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	0.450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetotwn University Curated by ChEMBL					Assay Description Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C epsilon				Bioorg Med Chem Lett 11: 955-9 (2001) BindingDB Entry DOI: 10.7270/Q2D799PV
Georgetotwn University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetotwn University Curated by ChEMBL					Assay Description Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C delta				Bioorg Med Chem Lett 11: 955-9 (2001) BindingDB Entry DOI: 10.7270/Q2D799PV
Georgetotwn University Curated by ChEMBL					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetotwn University Curated by ChEMBL					Assay Description Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C beta				Bioorg Med Chem Lett 11: 955-9 (2001) BindingDB Entry DOI: 10.7270/Q2D799PV
Georgetotwn University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetotwn University Curated by ChEMBL					Assay Description Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C alpha				Bioorg Med Chem Lett 11: 955-9 (2001) BindingDB Entry DOI: 10.7270/Q2D799PV
Georgetotwn University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, gamma (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	4.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetotwn University Curated by ChEMBL					Assay Description Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C gamma				Bioorg Med Chem Lett 11: 955-9 (2001) BindingDB Entry DOI: 10.7270/Q2D799PV
Georgetotwn University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RIKEN Advanced Science Institute Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from human recombinant PKCalpha after 20 mins by liquid scintillation counting				Bioorg Med Chem Lett 21: 3587-90 (2011) Article DOI: 10.1016/j.bmcl.2011.04.108 BindingDB Entry DOI: 10.7270/Q2HM58TF
RIKEN Advanced Science Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Luciferin 4-monooxygenase (Photinus pyralis)	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Indian Institute of Technology Madras Curated by ChEMBL					Assay Description Activation of firefly luciferase activity expressed in HEK293T cells after 6 hrs by luminescence assay				Bioorg Med Chem Lett 29: 585-590 (2019) Article DOI: 10.1016/j.bmcl.2018.12.057
Indian Institute of Technology Madras Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5.17E+3	n/a	n/a	n/a	n/a
University of Houston Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PKCdelta expressed in Escherichia coli BL21(DE3) by fluorescence quenching				Bioorg Med Chem 18: 1591-8 (2010) Article DOI: 10.1016/j.bmc.2009.12.075 BindingDB Entry DOI: 10.7270/Q2KP834V
University of Houston Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5.56E+3	n/a	n/a	n/a	n/a
University of Houston Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PKCepsilon expressed in Escherichia coli BL21(DE3) by fluorescence quenching				Bioorg Med Chem 18: 1591-8 (2010) Article DOI: 10.1016/j.bmc.2009.12.075 BindingDB Entry DOI: 10.7270/Q2KP834V
University of Houston Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.19E+3	n/a	n/a	n/a	n/a
University of Houston Curated by ChEMBL					Assay Description Binding affinity to GST-tagged PKCtheta expressed in Escherichia coli BL21(DE3) by fluorescence quenching				Bioorg Med Chem 18: 1591-8 (2010) Article DOI: 10.1016/j.bmc.2009.12.075 BindingDB Entry DOI: 10.7270/Q2KP834V
University of Houston Curated by ChEMBL					More data for this Ligand-Target Pair
RAS guanyl releasing protein 3 (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	82	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Activation of GFP-tagged RasGRP3 (unknown origin) expressed in HEK293 cells after 30 mins by immunoblot method				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
Seoul National University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, PKC; classical/novel (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Activation of PKCdelta (unknown origin) expressed in HEK293 cells harboring GFP-tagged RasGRP3 assessed as phosphorylation at ser299 residues after 3...				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
Seoul National University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	9.5	n/a	n/a	n/a	n/a
Kaohsiung Medical University Curated by ChEMBL					Assay Description Activation of PKC in human platelet assessed as induction of platelet aggregation measured within 15 mins by tribidimetric method				J Nat Prod 79: 2658-2666 (2016) Article DOI: 10.1021/acs.jnatprod.6b00603 BindingDB Entry DOI: 10.7270/Q24T6N3M
Kaohsiung Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50099066 (CHEMBL279115 \| phorbol 13-acetate 12-myristate) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.70E+6	n/a	n/a	n/a	n/a
University of Houston Curated by ChEMBL					Assay Description Binding affinity to recombinant C1 domain of PKCalpha expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence quenching assay				Bioorg Med Chem 19: 5321-33 (2011) Article DOI: 10.1016/j.bmc.2011.08.008 BindingDB Entry DOI: 10.7270/Q25H7GN9
University of Houston Curated by ChEMBL					More data for this Ligand-Target Pair