BindingDB PrimarySearch

BDBM50154943 CHEMBL3775576

SMILES: CNC(=O)c1ccc2[nH]nc(Cc3ccc4n(C)ncc4c3)c2c1

InChI Key: InChIKey=ZKGWDQMQMQRGLJ-UHFFFAOYSA-N

Data: 9 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50154943
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50154943 (CHEMBL3775576) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of human ERG				Bioorg Med Chem Lett 26: 1443-51 (2016) BindingDB Entry DOI: 10.7270/Q2NZ89G6
Merck KGaA Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50154943 (CHEMBL3775576) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of 5HT2A (unknown origin)				Bioorg Med Chem Lett 26: 1443-51 (2016) BindingDB Entry DOI: 10.7270/Q2NZ89G6
Merck KGaA Curated by ChEMBL					More data for this Ligand-Target Pair
PAS domain-containing serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50154943 (CHEMBL3775576) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of PASK (unknown origin)				Bioorg Med Chem Lett 26: 1443-51 (2016) BindingDB Entry DOI: 10.7270/Q2NZ89G6
Merck KGaA Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50154943 (CHEMBL3775576) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of CDK8-dependent WNT signalling in human LS174T cells in absence of WNT ligand				Bioorg Med Chem Lett 26: 1443-51 (2016) BindingDB Entry DOI: 10.7270/Q2NZ89G6
Merck KGaA Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50154943 (CHEMBL3775576) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity to CDK8/Cyclin C (unknown origin) by reporter displacement assay				Bioorg Med Chem Lett 26: 1443-51 (2016) BindingDB Entry DOI: 10.7270/Q2NZ89G6
Merck KGaA Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50154943 (CHEMBL3775576) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of CDK8-mediated STAT1 phosphorylation at serine727 in human SW620 cells harboring APC mutant				Bioorg Med Chem Lett 26: 1443-51 (2016) BindingDB Entry DOI: 10.7270/Q2NZ89G6
Merck KGaA Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50154943 (CHEMBL3775576) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay				Bioorg Med Chem Lett 26: 1443-51 (2016) BindingDB Entry DOI: 10.7270/Q2NZ89G6
Merck KGaA Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50154943 (CHEMBL3775576) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...				Bioorg Med Chem Lett 26: 1443-51 (2016) BindingDB Entry DOI: 10.7270/Q2NZ89G6
Merck KGaA Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50154943 (CHEMBL3775576) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of CDK8-dependent WNT signalling in human LS174T cells in presence of WNT3a ligand				Bioorg Med Chem Lett 26: 1443-51 (2016) BindingDB Entry DOI: 10.7270/Q2NZ89G6
Merck KGaA Curated by ChEMBL					More data for this Ligand-Target Pair