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BDBM50246088 2-methyl-2-[2-methyl-4-({[1-methyl-5-(2'-methyl-biphenyl-4-yl)-1H-pyrazole-3-carbonyl]-amino}-methyl)-phenoxy]-propionic acid::CHEMBL472399

SMILES: Cc1cc(CNC(=O)c2cc(-c3ccc(cc3)-c3ccccc3C)n(C)n2)ccc1OC(C)(C)C(O)=O

InChI Key: InChIKey=BIPCJUYHEQBDLC-UHFFFAOYSA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50246088   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peroxisome proliferator-activated receptor gamma


(Mus musculus)
BDBM50246088
PNG
(2-methyl-2-[2-methyl-4-({[1-methyl-5-(2'-methyl-bi...)
Show SMILES Cc1cc(CNC(=O)c2cc(-c3ccc(cc3)-c3ccccc3C)n(C)n2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C30H31N3O4/c1-19-8-6-7-9-24(19)22-11-13-23(14-12-22)26-17-25(32-33(26)5)28(34)31-18-21-10-15-27(20(2)16-21)37-30(3,4)29(35)36/h6-17H,18H2,1-5H3,(H,31,34)(H,35,36)
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PC sid
UniChem
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n/an/an/an/a 60n/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Agonist activity at mouse PPARgamma receptor by cell based transient transfection assay


Bioorg Med Chem Lett 18: 6251-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.094
BindingDB Entry DOI: 10.7270/Q20Z733H
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50246088
PNG
(2-methyl-2-[2-methyl-4-({[1-methyl-5-(2'-methyl-bi...)
Show SMILES Cc1cc(CNC(=O)c2cc(-c3ccc(cc3)-c3ccccc3C)n(C)n2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C30H31N3O4/c1-19-8-6-7-9-24(19)22-11-13-23(14-12-22)26-17-25(32-33(26)5)28(34)31-18-21-10-15-27(20(2)16-21)37-30(3,4)29(35)36/h6-17H,18H2,1-5H3,(H,31,34)(H,35,36)
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antibodypedia
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PC sid
UniChem
Article
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n/an/an/an/a 90n/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha receptor by cell based transient transfection assay


Bioorg Med Chem Lett 18: 6251-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.094
BindingDB Entry DOI: 10.7270/Q20Z733H
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Mus musculus)
BDBM50246088
PNG
(2-methyl-2-[2-methyl-4-({[1-methyl-5-(2'-methyl-bi...)
Show SMILES Cc1cc(CNC(=O)c2cc(-c3ccc(cc3)-c3ccccc3C)n(C)n2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C30H31N3O4/c1-19-8-6-7-9-24(19)22-11-13-23(14-12-22)26-17-25(32-33(26)5)28(34)31-18-21-10-15-27(20(2)16-21)37-30(3,4)29(35)36/h6-17H,18H2,1-5H3,(H,31,34)(H,35,36)
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n/an/an/an/a>2.50E+4n/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Agonist activity at mouse PPARdelta receptor by cell based transient transfection assay


Bioorg Med Chem Lett 18: 6251-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.094
BindingDB Entry DOI: 10.7270/Q20Z733H
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50246088
PNG
(2-methyl-2-[2-methyl-4-({[1-methyl-5-(2'-methyl-bi...)
Show SMILES Cc1cc(CNC(=O)c2cc(-c3ccc(cc3)-c3ccccc3C)n(C)n2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C30H31N3O4/c1-19-8-6-7-9-24(19)22-11-13-23(14-12-22)26-17-25(32-33(26)5)28(34)31-18-21-10-15-27(20(2)16-21)37-30(3,4)29(35)36/h6-17H,18H2,1-5H3,(H,31,34)(H,35,36)
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n/an/an/an/a 30n/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma receptor by cell based transient transfection assay


Bioorg Med Chem Lett 18: 6251-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.094
BindingDB Entry DOI: 10.7270/Q20Z733H
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Mus musculus)
BDBM50246088
PNG
(2-methyl-2-[2-methyl-4-({[1-methyl-5-(2'-methyl-bi...)
Show SMILES Cc1cc(CNC(=O)c2cc(-c3ccc(cc3)-c3ccccc3C)n(C)n2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C30H31N3O4/c1-19-8-6-7-9-24(19)22-11-13-23(14-12-22)26-17-25(32-33(26)5)28(34)31-18-21-10-15-27(20(2)16-21)37-30(3,4)29(35)36/h6-17H,18H2,1-5H3,(H,31,34)(H,35,36)
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n/an/an/an/a 1.80E+3n/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Agonist activity at mouse PPARalpha receptor by cell based transient transfection assay


Bioorg Med Chem Lett 18: 6251-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.094
BindingDB Entry DOI: 10.7270/Q20Z733H
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50246088
PNG
(2-methyl-2-[2-methyl-4-({[1-methyl-5-(2'-methyl-bi...)
Show SMILES Cc1cc(CNC(=O)c2cc(-c3ccc(cc3)-c3ccccc3C)n(C)n2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C30H31N3O4/c1-19-8-6-7-9-24(19)22-11-13-23(14-12-22)26-17-25(32-33(26)5)28(34)31-18-21-10-15-27(20(2)16-21)37-30(3,4)29(35)36/h6-17H,18H2,1-5H3,(H,31,34)(H,35,36)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>2.50E+4n/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta receptor by cell based transient transfection assay


Bioorg Med Chem Lett 18: 6251-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.094
BindingDB Entry DOI: 10.7270/Q20Z733H
More data for this
Ligand-Target Pair